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CHMP recommends approval of upadacitinib (RINVOQ®) for the treatment of adults with active non-radiographic axial spondyloarthritis

AbbVie today announced the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) recommended the approval of upadacitinib (RINVOQ® 15 mg, once daily) for the treatment of active non-radiographic axial spondyloarthritis (nr‑axSpA) in adult patients with objective signs of inflammation as indicated by elevated C-reactive protein (CRP) and/or magnetic resonance imaging (MRI), who have responded inadequately to nonsteroidal anti-inflammatory drugs (NSAIDs).*

27 Jun 2022

Using AI to save the lives of mothers and babies

As part of our SLAS Europe 2022 coverage, we speak to Professor Patricia Maguire from the University College Dublin about their AI_PREMie technology.

From Society for Laboratory Automation and Screening (SLAS) 24 Jun 2022

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

In a recent study posted to the medRxiv* pre-print server, researchers in the United States characterized differential host immune responses in acute coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) to inform future development of novel biomarkers for both diseases.

23 Jun 2022

Mild COVID causes increase in neurotoxic metabolites

In a recent study posted to the bioRxiv* pre-print server, researchers investigated the blood levels of neurotoxic metabolites in patients with mild coronavirus disease 2019 (COVID-19).

23 Jun 2022

Researchers model a complex childhood disease on-a-chip

Millions of children in low- and middle-income nations suffer from environmental enteric dysfunction (EED), a chronic inflammatory disease of the intestine that is the second leading cause of death in children under five years old.

23 Jun 2022

Study links post-COVID symptoms with alterations in gut microbiota

A team of scientists has recently highlighted the significance of gut microbiota alterations induced by SARS-CoV-2 in triggering post-COVID-19 symptoms.

23 Jun 2022

New funding to help advance scientific understanding of skin disorders in children and young people

For children and young people, skin disorders can have a devastating impact on physical and mental wellbeing, yet effective treatments are few and far between.

23 Jun 2022

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Colorectal, pancreatic, esophageal and stomach cancers - some of the deadliest kinds of cancer - have high recurrence rates where the cancer comes back even after successful surgery or radiation treatment.

23 Jun 2022

Kratom: A dangerous or beneficial plant?

A new study summarizes the traditional and modern uses of kratom, as well as its pharmacology, benefits, and adverse health impacts.

23 Jun 2022

Simple blood test can predict liver cancer risk in NAFLD patients

An estimated one-quarter of adults in the U.S. have nonalcoholic fatty liver disease (NAFLD), an excess of fat in liver cells that can cause chronic inflammation and liver damage, increasing the risk of liver cancer.

22 Jun 2022

Novel drug molecule targets T-cells causing inflammation in heart failure patients

Researchers at The Ohio State University Wexner Medical Center and College of Medicine have developed a novel drug molecule that targets T-cells causing inflammation in heart failure patients, stopping further progression of the disease.

22 Jun 2022

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

In a recent review published in Immunity, researchers explored potential mechanisms of neuro-immune pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

22 Jun 2022

Specific retinal cell appears to be good at housing Ebola and other viruses

A specific cell within our retina, the light-sensitive part of our eyes responsible for sending visual information to our brain, appears to be particularly good at housing Ebola and other viruses, new research has found.

22 Jun 2022

Recipients of the first ever EFP Innovation Award for Digital Solutions for Gum Health announced

The European Federation of Periodontology has announced the recipients of the first ever EFP Innovation Award for Digital Solutions for Gum Health supported by GSK.

21 Jun 2022

Researchers identify the role of TREM2-positive macrophages in non-alcoholic fatty liver disease

A MedUni Vienna study team has identified the role of a specific subtype of macrophages (white blood cells) in progressive non-alcoholic fatty liver disease.

21 Jun 2022

UTSW study provides a potential avenue for the development of new antivirals against influenza

A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands.

20 Jun 2022

Proteins in liquor could provide information about inflammatory processes in the brain

Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain.

20 Jun 2022

Researchers highlight the impact of macrophage subtypes on acute kidney injury to CKD transition

Acute kidney injury (AKI) is a condition in which kidneys are unable to filter waste from the blood effectively, leading to various health complications.

20 Jun 2022

The feasibility of sperm cryopreservation for male COVID-19 patients

In an article recently published in Frontiers in Endocrinology, scientists deciphered the possibility of cryopreserving sperm of coronavirus disease 2019 (COVID-19) patients

20 Jun 2022

Study points to a new direction for the development of NAMPT-targeted cancer therapies

In this new article publication from Acta Pharmaceutica Sinica B, authors Ying Wu, Congying Pu, Yixian Fu, Guoqiang Dong, Min Huang and Chunquan Sheng from Second Military Medical University, Shanghai, China and University of Chinese Academy of Sciences, Shanghai, China discuss how NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion.

18 Jun 2022

Inflammation News and Research

CHMP recommends approval of upadacitinib (RINVOQ®) for the treatment of adults with active non-radiographic axial spondyloarthritis

Using AI to save the lives of mothers and babies

Overlap in pro-inflammatory genes and pathways between COVID-19 and MIS-C

Mild COVID causes increase in neurotoxic metabolites

Researchers model a complex childhood disease on-a-chip

Study links post-COVID symptoms with alterations in gut microbiota

New funding to help advance scientific understanding of skin disorders in children and young people

Listeria-based booster vaccine strategy offers improved protection against recurrent colorectal cancer

Kratom: A dangerous or beneficial plant?

Simple blood test can predict liver cancer risk in NAFLD patients

Novel drug molecule targets T-cells causing inflammation in heart failure patients

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

Specific retinal cell appears to be good at housing Ebola and other viruses

Recipients of the first ever EFP Innovation Award for Digital Solutions for Gum Health announced

Researchers identify the role of TREM2-positive macrophages in non-alcoholic fatty liver disease

UTSW study provides a potential avenue for the development of new antivirals against influenza

Proteins in liquor could provide information about inflammatory processes in the brain

Researchers highlight the impact of macrophage subtypes on acute kidney injury to CKD transition

The feasibility of sperm cryopreservation for male COVID-19 patients

Study points to a new direction for the development of NAMPT-targeted cancer therapies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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