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Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Scientists at St. Jude Children's Research Hospital identified a molecular mechanism that in a preclinical study unlocked the promise of CAR T–cell therapy for treatment of solid tumors.

22 Jun 2022

Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

Bacteria causing typhoid fever are highly developing antibiotic resistance

Bacteria causing Typhoid fever are becoming increasingly resistant to some of the most important antibiotics for human health, according to a study published in The Lancet Microbe journal. The largest genome analysis of Salmonella enterica serovar Typhi (S. Typhi) also reveals that resistant strains - almost all originating in South Asia - have spread to other countries nearly 200 times since 1990.

22 Jun 2022

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

A collaborative team of scientists led by Mayo Clinic's Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome.

21 Jun 2022

Wistar scientists discover a new way to boost a person's immune response to tumors

Due to the development of resistance to chemotherapy and recurring tumors, patients with ovarian cancer often have low survival rates.

21 Jun 2022

TB-causing bacteria can evolve rapidly in response to new environments, study says

Researchers have identified how the bacterium that causes tuberculosis (TB) can evolve rapidly in response to new environments, says a study published today in eLife.

21 Jun 2022

A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Similar to Alzheimer's disease, the hereditary disease spinocerebellar ataxia type 17 (SCA17) leads to the destruction of brain nerve cells and the premature death of patients.

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

UTSW study provides a potential avenue for the development of new antivirals against influenza

A collaborative study from UT Southwestern scientists has identified a new function for a protein called TAO2 that appears to be key to inhibiting replication of the influenza virus, which sickens millions of individuals worldwide each year and kills hundreds of thousands.

20 Jun 2022

Study offers new insight into the growth of blood vessels

Blood vessels must adapt their growth to the nutrients available in their surroundings so that they can keep organs adequately supplied. A team led by Michael Potente has identified two proteins that are important for this process and published their findings in Nature Metabolism.

20 Jun 2022

New model rapidly scans the genome of cancer cells and identifies mutations that drive tumor growth

Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.

20 Jun 2022

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Researchers demonstrated that impaired type I interferon immunity is associated with increasing coronavirus disease 2019 severity.

20 Jun 2022

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

A new genetic discovery adds weight to a theory that motor neurone degenerative diseases are caused by abnormal lipid (fat) processing pathways inside brain cells.

20 Jun 2022

Gut microbiome acts on the brain to control appetite

Hypothalamic GABAergic neurons recognize microbial muropeptides through the cytosolic receptor NOD2, which regulates food intake and body temperature.

19 Jun 2022

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.

17 Jun 2022

Conceptual framework to examine the patterns of copy number alterations in human cancer

A new study published in Nature presented a conceptual framework to examine the patterns of copy number alterations in human cancer.

17 Jun 2022

New research helps to better understand the basic biology of nerve cells

Scientists are starting to understand the precise workings of a type of gene that, unlike other genes, does not code for proteins – the building blocks of life.

16 Jun 2022

Genetic screening algorithm can estimate a person's risk of developing chronic kidney disease

A new algorithm developed by researchers at Columbia University can analyze thousands of variants across the genome and estimate a person's risk of developing chronic kidney disease - and it works in people of African, Asian, European, and LatinX descent.

16 Jun 2022

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

UiO researchers find 13 special genes related to epigenetic changes in cancer samples

Abnormal epigenetic changes are observed in the development of multiple types of cancer. Researchers at Centre for Molecular Medicine Norway (UiO) found 13 special genes linked to epigenetic changes in cancer samples.

16 Jun 2022

Genes News and Research

Preclinical study unlocks the promise of CAR T-cell therapy for treatment of solid tumors

Researchers map cancer driver mutations across the human genome

Bacteria causing typhoid fever are highly developing antibiotic resistance

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

Wistar scientists discover a new way to boost a person's immune response to tumors

TB-causing bacteria can evolve rapidly in response to new environments, study says

A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

UTSW study provides a potential avenue for the development of new antivirals against influenza

Study offers new insight into the growth of blood vessels

New model rapidly scans the genome of cancer cells and identifies mutations that drive tumor growth

Implications of impaired type I interferon immunity and increasing COVID-19 severity

Genetic discovery may pave the way to new diagnostic approaches, treatments for motor neurone diseases

Gut microbiome acts on the brain to control appetite

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Conceptual framework to examine the patterns of copy number alterations in human cancer

New research helps to better understand the basic biology of nerve cells

Genetic screening algorithm can estimate a person's risk of developing chronic kidney disease

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

UiO researchers find 13 special genes related to epigenetic changes in cancer samples

eBook: Using iPSCs models for human disease research and drug discovery eBook

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