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Extracellular Vesicle Isolation and Characterization

In this interview, News Medical talks to Dr. Carly Ross, from Beckman Coulter Life sciences about extracellular vesicle isolation and characterization.

From Beckman Coulter Life Sciences - Flow Cytometry 23 Mar 2016

Targeted therapies suppress T cell activity that could actually help fight tumors

In many cases, targeted therapies for cancer are preferred as treatments over chemotherapy and surgery because they attack and kill cancer cells with specific tumor-promoting mutations while sparing healthy, normal cells that do not express these mutations.

23 Mar 2016

Mutations in cancerous lymphoma cells break through four protein locks

Protein chemists at Johns Hopkins report they are closer to explaining why certain blood cancers are able to crack a molecular security system and run rampant.

22 Mar 2016

Research sheds new light on genetic relationship between ASD and ASD-related traits in wider population

New light has been shed on the genetic relationship between autistic spectrum disorders (ASD) and ASD-related traits in the wider population, by a team of international researchers including academics from the University of Bristol, the Broad Institute of Harvard and MIT, and Massachusetts General Hospital.

22 Mar 2016

Four key genes govern growth, multiplication of blood stem cells

An important element in getting blood stem cells to multiply outside the body is to understand which of the approximately 20,000 genes in the human body control their growth. Now a research team at Lund University in Sweden has studied close to 15,000 of these genes alongside each other.

22 Mar 2016

Specialized gene editing system paves way to eventual cure for HIV patients

A specialized gene editing system designed by scientists at the Lewis Katz School of Medicine at Temple University is paving the way to an eventual cure for patients infected with HIV, the virus that causes AIDS.

22 Mar 2016

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

When mutated, a gene known for its ability to repair DNA, appears to instead cause breast cancer, scientists report.

21 Mar 2016

Novel compound shows promise as potential treatment for acute myeloid leukemia

A novel compound has shown promise in preclinical studies as a treatment for acute myeloid leukemia, more than doubling median days of survival even in a drug-resistant form of the disease.

21 Mar 2016

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Acute myeloid leukemia (AML) is a cancer of myeloid stem cells that develops in both adult and pediatric populations. Mutations that cause hyperactivation of the FMS-like tyrosine kinase 3 (FLT3) are commonly found in AML, and several clinical trials are testing FLT3 inhibitors.

21 Mar 2016

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Cobimetinib (trade name: Cotellic) has been approved since November 2015 in combination with vemurafenib for the treatment of adults with advanced, i.e. metastatic or unresectable, melanoma with a BRAF V600 mutation.

21 Mar 2016

Six1 gene may have more substantial role in human kidney development

The best laid plans of mice and men are a bit different -- at least when it comes to kidney development. Compared to a mouse, a human has nearly 100 times more nephrons, the functional units of the kidneys. Humans may owe these abundant nephrons to a gene called SIX1, according to a new paper published in the journal Development.

21 Mar 2016

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Carmen Buxó-Martínez, University of Puerto Rico, San Juan, will present a study titled "Identification of Rare ADCY9 Mutations and Non-syndromic Oral Clefts in Puerto Ricans." The AADR Annual Meeting is being held in conjunction with the 40th Annual Meeting of the Canadian Association for Dental Research.

19 Mar 2016

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Cedars-Sinai research scientists have found that immune cells in the brain play a direct role in the development of amyotrophic lateral sclerosis, or ALS, offering hope for new therapies to target the neurodegenerative disease that gradually leads to paralysis and death.

18 Mar 2016

Study sheds light on role of RNA editing in cancer

A new study provides insight on the potential role played by RNA (ribonucleic acid) editing in cancer. The findings, which appear online in the journal Scientific Reports, may further our understanding of an emerging mechanism implicated in tumor initiation and progression, and may thus lead to the development of better treatment options in the future.

18 Mar 2016

New study reveals why certain cancer drugs not always effective in halting tumor growth

New cancer drugs allow doctors to tailor treatment based on the genetic profile of a patient's tumor. However, these drugs don't work at all in some patients, and they lose their effectiveness in others.

17 Mar 2016

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

About half of children born with Jacobsen syndrome, a rare inherited disease, experience social and behavioral issues consistent with autism spectrum disorders. Researchers at University of California, San Diego School of Medicine and collaborators developed a mouse model of the disease that also exhibits autism-like social behaviors and used it to unravel the molecular mechanism that connects the genetic defects inherited in Jacobsen syndrome to effects on brain function.

16 Mar 2016

Researchers explore problem of obesity from the inside out

In the last 40 years, obesity has more than doubled around the world. In the United States, the average American is more than 24 pounds heavier today than in 1960. Researchers at Baylor College of Medicine, Technion-Israel Institute of Technology and the University of Washington are studying the problem of obesity from the inside out.

16 Mar 2016

'Classic doctoring' still has big role to play in diagnosis, treatment of neurocutaneous syndromes

A pair of neurologists at Nationwide Children's Hospital, Monica P. Islam, MD, and E. Steve Roach, MD, are the editors behind "Neurocutaneous Syndromes," a recently published book that highlights the insights of neurocutaneous syndromes research and shows that "classic doctoring" still has a big role to play in diagnosis and treatment.

16 Mar 2016

Diet-induced obesity, diabetes can be epigenetically inherited by offspring, say scientists

Scientists at Helmholtz Zentrum München, in collaboration with researchers from Technical University of Munich and the German Center for Diabetes Research, have shown that diet-induced obesity and diabetes can be epigenetically inherited by the offspring via both the oocytes and the sperm.

16 Mar 2016

DelMar's VAL-083 receives FDA orphan drug designation for treatment of medulloblastoma

DelMar Pharmaceuticals, Inc., announced today that the FDA Office of Orphan Products Development (OOPD) has granted orphan drug designation for its lead product candidate, VAL-083, in the treatment of medulloblastoma.

15 Mar 2016

Mutation News and Research

Extracellular Vesicle Isolation and Characterization

Targeted therapies suppress T cell activity that could actually help fight tumors

Mutations in cancerous lymphoma cells break through four protein locks

Research sheds new light on genetic relationship between ASD and ASD-related traits in wider population

Four key genes govern growth, multiplication of blood stem cells

Specialized gene editing system paves way to eventual cure for HIV patients

Mutated gene GT198 has strong potential in early diagnosis of breast cancer

Novel compound shows promise as potential treatment for acute myeloid leukemia

MRX-2843 treatment improves survival of acute myeloid leukemia patients

Cobimetinib with vemurafenib may have added benefit in melanoma with BRAF V600 mutation

Six1 gene may have more substantial role in human kidney development

Rare ADCY9 mutations linked to non-syndromic oral clefts in Puerto Ricans

Brain's immune cells play direct role in development of amyotrophic lateral sclerosis

Study sheds light on role of RNA editing in cancer

New study reveals why certain cancer drugs not always effective in halting tumor growth

Anti-anxiety drug reduces autistic features in Jacobsen syndrome mice

Researchers explore problem of obesity from the inside out

'Classic doctoring' still has big role to play in diagnosis, treatment of neurocutaneous syndromes

Diet-induced obesity, diabetes can be epigenetically inherited by offspring, say scientists

DelMar's VAL-083 receives FDA orphan drug designation for treatment of medulloblastoma

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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