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First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

A rare malignancy known as squamous cell carcinoma of the anal canal (SCCA) is on the increase, and now researchers have reported results of the first-ever phase II clinical trial results for treatment with the immunotherapy drug nivolumab.

18 Apr 2016

MGH-led study confirms safety of allergy immunotherapy

A team of Massachusetts General Hospital investigators has found no evidence of infections related to administration of allergy immunotherapy, the common practice of injecting minimal quantities of allergens beneath the skin to reduce the allergic response.

18 Apr 2016

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

A multi-institutional study led by a Massachusetts General Hospital investigator finds significant racial disparities in the risk that patients being treated for gout will develop a serious, sometimes life-threatening adverse reaction to the most commonly prescribed medication. The increased risk closely correlates with the frequency of a gene variant previously associated with that adverse reaction, supporting recommendations to screen for that variant in patients from those populations.

16 Apr 2016

New clinical data highlights potential of AB-PA01 to treat P. aeruginosa infections in CF patients

AmpliPhi Biosciences Corporation, a global leader in the development of bacteriophage-based antibacterial therapies to treat drug-resistant infections, presented data at the European Congress of Clinical Microbiology and Infectious Diseases summarizing both the in vitro and in vivo activity of its proprietary, investigational phage mix AB-PA01.

13 Apr 2016

Inexpensive paper tape can help prevent incidence and frequency of foot blisters

Ten years ago, Grant Lipman, MD, an emergency medicine physician, was working as a doctor for endurance athletes who were running 25 to 50 miles a day in various parts of the world, from China to Antarctica to Chile.

12 Apr 2016

Flexible ramp scripting interface added for BioScope Resolve BioAFM

At the 7th AFM BioMed Conference, Bruker’s Nano Surfaces Division today announced the release of RampScript™, which provides extensive new scripting capabilities for the BioScope Resolve® BioAFM. BioScope Resolve has set new standards for highest resolution AFM imaging with the first ever images of microvilli on live cells and by routinely resolving submolecular structures, such as the major and minor groove of DNA, while operating on an inverted microscope.

From Bruker Nano Surfaces and Metrology 11 Apr 2016

High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

At the 57th Experimental Nuclear Magnetic Resonance Conference (www.enc-conference.org), Bruker is showcasing several innovative drug discovery, drug development and process control solutions for small molecule NMR characterization in the chemical and pharmaceutical industries.

From Bruker BioSpin Division 11 Apr 2016

Older American men pay for more sex as they age, study finds

Older American male customers of sex workers pay for more sex as they age. These findings are reported in a study which surveyed older American men who frequent sex work websites and discussion boards. It was conducted by Los Angeles-based psychotherapist Christine Milrod and sociologist Martin Monto of the University of Portland in the US and published in Springer's journal Archives of Sexual Behavior.

7 Apr 2016

Entresto drug shows added benefit in symptomatic chronic heart failure

The fixed-dose combination of sacubitril and valsartan (trade name: Entresto) has been approved since November 2015 for adults with symptomatic chronic heart failure with reduced pump function (ejection fraction). The German Institute for Quality and Efficiency in Health Care (IQWiG) now examined in an early benefit assessment whether this drug combination offers an added benefit for patients in comparison with the appropriate comparator therapy.

7 Apr 2016

Epileptologists develop mobile sensor that can detect seizures

For epilepsy patients and attending physicians, it has been a challenge to correctly assess the frequency and severity of epileptic seizures without inpatient recording equipment. A consortium coordinated by the epileptologists of the University Hospital Bonn is now developing a mobile sensor that can detect seizures.

7 Apr 2016

New extended-release pills could reduce dosage frequency of some drugs

Researchers from MIT and Brigham and Women's Hospital have designed a new type of pill that, once swallowed, can attach to the lining of the gastrointestinal tract and slowly release its contents. The tablet is engineered so that one side adheres to tissue, while the other repels food and liquids that would otherwise pull it away from the attachment site.

7 Apr 2016

Scientists detect FFR signals from previously unknown part of the brain

Scientists at the Montreal Neurological Institute and Hospital at McGill University have made an important discovery about the human auditory system and how to study it, findings that could lead to better testing and diagnosis of hearing-related disorders.

7 Apr 2016

Study shows how Down Syndrome gene associated with altered oscillations in the cerebral cortex

Cerebral activity is governed by a fine balance between neuronal excitation and inhibition. Specifically, neurons are activated by excitation mechanisms tightly regulated by inhibition processes. For certain functions, the neuronal network needs to be synchronized.

6 Apr 2016

Latest trends in robotic surgery: an interview with Dr. Patrick Ross, Chairman of Surgery for Main Line Health

When new technology becomes available, surgical or otherwise, there are those who adopt early, and those who hold on to previous familiar methods.

6 Apr 2016

Cutting energy-dense carbohydrate-containing foods may help reduce cancer risk

Recent years have brought more attention to the role of carbohydrates in our diets and the differences between healthy and unhealthy carbs, most often in the context of weight control. A new study highlights one more reason to avoid sugary beverages, processed foods and other energy-dense carbohydrate-containing foods—cutting them may help reduce your risk of cancer.

6 Apr 2016

Study elucidates potential benefits of antiarrhythmic drugs for out-of-hospital cardiac arrest patients

Paramedics often give heart rhythm stabilizing drugs to patients who are suffering out-of-hospital cardiac arrest when they fail to regain a stable heart rhythm after electrical shock treatment.

5 Apr 2016

Tests used for diagnosing heart disease appear to function differently for women and men

Tests used to diagnose and assess the severity of coronary artery disease appear to function differently for women and men who have stable symptoms, according to researchers from Duke Clinical Research Institute.

5 Apr 2016

Edema Guard Monitor appears to reduce heart failure-related hospitalizations by more than half

In patients with heart failure, use of an investigational device that monitors the accumulation of fluid in the lungs appeared to cut heart failure-related hospitalizations by more than half, meeting the study's primary endpoint, and reduced deaths from any cause by 39 percent per year compared with standard assessment and treatment, researchers reported at the American College of Cardiology's 65th Annual Scientific Session.

5 Apr 2016

Prostatic artery embolization improves sleep, quality of life for men with enlarged prostates

An innovative interventional radiology treatment for men with enlarged prostates decreases the number of times they wake to urinate in the night, according to research presented at the Society of Interventional Radiology's 2016 Annual Scientific Meeting. Researchers said the majority of men with enlarged prostates and lower urinary tract symptoms reported better sleep that resulted in an improved quality of life after they underwent a treatment called prostatic artery embolization (PAE).

4 Apr 2016

Blast-related concussions result in hormone changes that lead to poor quality of life among veterans

A study in military veterans finds that explosive blast-related concussions frequently result in hormone changes leading to problems such as sleep disturbances, fatigue, depression and poor quality of life. The research, to be presented Saturday at the Endocrine Society's 98th annual meeting in Boston, evaluated hormone levels in 41 male veterans who had been deployed to Iraq or Afghanistan.

4 Apr 2016

Frequency News and Research

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

MGH-led study confirms safety of allergy immunotherapy

Study supports screening for HLA-B*5801 gene variant in Asian, black patients with gout

New clinical data highlights potential of AB-PA01 to treat P. aeruginosa infections in CF patients

Inexpensive paper tape can help prevent incidence and frequency of foot blisters

Flexible ramp scripting interface added for BioScope Resolve BioAFM

High–performance, cost-effective NMR solutions for the pharmaceutical and chemical industries

Older American men pay for more sex as they age, study finds

Entresto drug shows added benefit in symptomatic chronic heart failure

Epileptologists develop mobile sensor that can detect seizures

New extended-release pills could reduce dosage frequency of some drugs

Scientists detect FFR signals from previously unknown part of the brain

Study shows how Down Syndrome gene associated with altered oscillations in the cerebral cortex

Latest trends in robotic surgery: an interview with Dr. Patrick Ross, Chairman of Surgery for Main Line Health

Cutting energy-dense carbohydrate-containing foods may help reduce cancer risk

Study elucidates potential benefits of antiarrhythmic drugs for out-of-hospital cardiac arrest patients

Tests used for diagnosing heart disease appear to function differently for women and men

Edema Guard Monitor appears to reduce heart failure-related hospitalizations by more than half

Prostatic artery embolization improves sleep, quality of life for men with enlarged prostates

Blast-related concussions result in hormone changes that lead to poor quality of life among veterans

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