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DDT exposure found to alter sperm epigenome in humans

In a study that signals potential reproductive and health complications in humans, now and for future generations, researchers from McGill University, the University of Pretoria, Université Laval, Aarhus University, and the University of Copenhagen, have concluded that fathers exposed to environmental toxins, notably DDT, may produce sperm with health consequences for their children.

9 Feb 2024

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease

Drugs commonly used to treat erectile dysfunction may reduce the risk of Alzheimer's disease, finds a new study led by UCL researchers.

9 Feb 2024

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

Targeting senescent cells in the retina with a BCL-xL inhibitor shows promise as a durable treatment for diabetic macular edema, potentially offering long-term visual function improvements.

8 Feb 2024

New cervical cancer detection method promises to reduce unnecessary screenings

The BMC Medicine study introduces the CerMe detection method, using PCDHGB7 hypermethylation to effectively triage high-risk HPV-positive women, potentially reducing unnecessary colposcopy referrals.

8 Feb 2024

New mouse model illuminates lung cancer's transformation into aggressive variant

Lung tumors called adenocarcinomas sometimes respond to initially effective treatments by transforming into a much more aggressive small cell lung cancer (SCLC) that spreads rapidly and has few options for treatment.

8 Feb 2024

Decoding the differences between two vital RNA transport complexes

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages.

8 Feb 2024

Never-before-documented genetic disorder causes rare lung disease

The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.

8 Feb 2024

New MRI method enables early detection and better monitoring of multiple sclerosis

Multiple sclerosis (MS) is a neurological disease that usually leads to permanent disabilities. It affects around 2.9 million people worldwide, and around 15,000 in Switzerland alone.

8 Feb 2024

Higher dietary niacin intake linked to lower COPD risk, study finds

Recent research in Scientific Reports reveals a dose-response relationship between dietary niacin intake and reduced prevalence of chronic obstructive pulmonary disease (COPD), suggesting niacin's potential role in mitigating oxidative stress and inflammation in COPD patients.

8 Feb 2024

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

CD4+ T cells have been highlighted in the scientific literature for the important role they play in the immune response to lung infections.

8 Feb 2024

Mitochondrial misfire sparks inflammation

Cells in the human body contain power-generating mitochondria, each with their own mtDNA - a unique set of genetic instructions entirely separate from the cell's nuclear DNA that mitochondria use to create life-giving energy.

8 Feb 2024

New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

A new research perspective was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Preclinical and clinical evaluation of the Janus Kinase inhibitor ruxolitinib in multiple myeloma."

8 Feb 2024

Enzyme released by immune cells may play role in depression

Mount Sinai researchers have shown for the first time that immune cells called monocytes, derived in the bone marrow and released into the bloodstream, can be drawn during stress into sites in the brain that control emotional behaviors.

8 Feb 2024

New immunotherapy borrows cancer's tricks to unleash powerful T cells

Immunotherapies using engineered T cells have ushered in a new era in cancer treatment, but they have their limits. They may cause side effects or stop working, and they do not work at all against 90% of cancers.

8 Feb 2024

Study advances search for a blood test to identify disease-associated changes in the brain

Researchers in a Johns Hopkins Children's Center-led study that used genetic material from human blood and lab-grown brain cells say they have made progress in developing a blood test to identify disease-associated changes in the brain specifically linked to postpartum depression and other psychiatric and neurological disorders.

8 Feb 2024

Study discovers a direct connection between the brain and its surrounding environment

In a recent study of the brain's waste drainage system, researchers from Washington University in St. Louis, collaborating with investigators at the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institute of Health (NIH), discovered a direct connection between the brain and its tough protective covering, the dura mater.

8 Feb 2024

Monash-led study unveils potential long-term treatment for lupus

Researchers assessed Smith (Sm)-specific regulatory T cells (Tregs) efficacy in halting lupus nephritis (LN) by engineering and testing epitope-targeted Tregs for systemic lupus erythematosus (SLE) treatment.

8 Feb 2024

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

A tiny device built by scientists at MIT and the Singapore-MIT Alliance for Research and Technology could be used to improve the safety and effectiveness of cell therapy treatments for patients suffering from spinal cord injuries.

7 Feb 2024

B Cell News and Research

DDT exposure found to alter sperm epigenome in humans

Men using erectile dysfunction drugs less likely to develop Alzheimer's disease

New treatment targeting aging cells could offer lasting relief for diabetic macular edema

New cervical cancer detection method promises to reduce unnecessary screenings

New mouse model illuminates lung cancer's transformation into aggressive variant

Decoding the differences between two vital RNA transport complexes

Never-before-documented genetic disorder causes rare lung disease

New MRI method enables early detection and better monitoring of multiple sclerosis

Higher dietary niacin intake linked to lower COPD risk, study finds

Immune cells in overdrive: Study finds unbalanced response worsens lung infections

Mitochondrial misfire sparks inflammation

New drug targets key mechanism in ALS, protects motor neurons

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

Hope for relapsed myeloma: Preclinical and clinical evidence for ruxolitinib's efficacy

Enzyme released by immune cells may play role in depression

New immunotherapy borrows cancer's tricks to unleash powerful T cells

Study advances search for a blood test to identify disease-associated changes in the brain

Study discovers a direct connection between the brain and its surrounding environment

Monash-led study unveils potential long-term treatment for lupus

Tiny device could help improve safety, effectiveness of cell therapy for spinal cord injury patients

Using single B cell screening to boost antibody discovery eBook

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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