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Largest genetic study of heart failure finds new risk factors

In a new study co-led by investigators at the United States Department of Veterans Affairs and Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, a global team of scientists conducted one of the largest genetic association studies on heart failure to date.

24 Aug 2023

Pioneering drug for rare kidney disease improves outcome for patients

A pioneering drug for a rare kidney disease prevents organ failure and significantly improves the outcome for patients, new research has confirmed.

24 Aug 2023

Disruption of FOXA2 expression in congenital hyperinsulinism: The role of chromosome 20p11.2 deletions

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24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Dangers and deaths around Black pregnancies seen as a ‘completely preventable’ health crisis

Tonjanic Hill was overjoyed in 2017 when she learned she was 14 weeks pregnant. Despite a history of uterine fibroids, she never lost faith that she would someday have a child.

24 Aug 2023

New gene variant linked to Parkinson's disease found in people of African ancestry

A gene variant found almost exclusively in the genomes of people of African ancestry increases the risk of developing Parkinson's disease, according to an international study of nearly 198,000 participants with this genetic background.

23 Aug 2023

Swedish study changes national guidelines for genetic testing in breast cancer

BRCA1 and BRCA2 are well-known breast cancer genes associated with a significantly increased risk of hereditary breast and ovarian cancer. However, there are an additional eleven genes associated with elevated risk for these types of cancer.

23 Aug 2023

Long-read sequencing reveals new details of Bartter syndrome type 3

Bartter syndrome type 3 is the result of several structural variants in the genome. By using long-read sequencing, Janine Altmüller and her team from the Max Delbrück Center, the BIH and University Hospital Cologne mapped out the rare disease in unprecedented detail.

23 Aug 2023

Taking adult education classes may help prevent dementia

How can we best keep our brain fit as we grow older? It's well known that regular cognitive activity, for example brainteasers, sudokus, or certain video games in middle and old age tends to protect against cognitive decline and dementias like Alzheimer's.

23 Aug 2023

Skin signals neurons to grow the appropriate endings

Nerve cells that sense touch grow the appropriate endings for hairy or hairless skin based on cues from the skin itself, rather than through predetermined programming, according to research led by Harvard Medical School scientists and published Aug. 21 in Developmental Cell.

23 Aug 2023

Y chromosome fully mapped for the first time

What was once the final frontier of the human genome - the Y chromosome - has just been mapped out in its entirety.

23 Aug 2023

CPAP therapy can mitigate telomere shortening in sleep apnea patients

Obstructive sleep apnea (OSA) consists of multiple episodes of partial or complete closure of the upper airway that occur during sleep, leading to breathing cessation lasting more than ten seconds and sometimes even several minutes, followed by arousals and deep breathing.

23 Aug 2023

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The genetic etiology by whole-exome sequencing (WES).

23 Aug 2023

The gut microbiota associated with prediabetes and treatment naïve type 2 diabetes patients

The gut-inhabiting bacteria in pre-type 2 diabetes (pre-T2D) patients.

23 Aug 2023

Review explores relationship between sleep disorders and pregnancy

A recent review summarizes what is known about these conditions and suggests future research directions and opportunities.

23 Aug 2023

Scientists find way to 'press self-destruct button' in gastric cancer associated with Epstein-Barr Virus

Now, scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus; study results were published in the journal mBio.

22 Aug 2023

Music can trigger cells to release insulin within minutes

Diabetes is a condition in which the body produces too little or no insulin. Diabetics thus depend on an external supply of this hormone via injection or pump.

22 Aug 2023

AI-powered protein score predicts major atherosclerotic cardiovascular disease events

In a large retrospective analysis using measurements of thousands of plasma proteins in primary and secondary event populations, scientists from deCODE genetics a subsidiary of Amgen and collaborators from USA, Denmark and Iceland, reported today in The Journal of the American Medical Association (JAMA) how they employed AI to develop a protein score to predict major atherosclerotic cardiovascular disease events (ASCVD).

22 Aug 2023

High-fat diet changes gut bacteria, bile acids, and increases colorectal cancer risk

The prevalence of colorectal cancer in people under the age of 50 has risen in recent decades. One suspected reason: the increasing rate of obesity and high-fat diets.

22 Aug 2023

Genetically diverse mouse models offer new insights into Alzheimer's disease

A new study by Indiana University School of Medicine researchers uses more genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain - a known sign of Alzheimer's disease and several other neurodegenerative diseases.

22 Aug 2023

Genetic News and Research

Largest genetic study of heart failure finds new risk factors

Pioneering drug for rare kidney disease improves outcome for patients

Disruption of FOXA2 expression in congenital hyperinsulinism: The role of chromosome 20p11.2 deletions

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Dangers and deaths around Black pregnancies seen as a ‘completely preventable’ health crisis

New gene variant linked to Parkinson's disease found in people of African ancestry

Swedish study changes national guidelines for genetic testing in breast cancer

Long-read sequencing reveals new details of Bartter syndrome type 3

Taking adult education classes may help prevent dementia

Skin signals neurons to grow the appropriate endings

Y chromosome fully mapped for the first time

CPAP therapy can mitigate telomere shortening in sleep apnea patients

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The gut microbiota associated with prediabetes and treatment naïve type 2 diabetes patients

Review explores relationship between sleep disorders and pregnancy

Scientists find way to 'press self-destruct button' in gastric cancer associated with Epstein-Barr Virus

Music can trigger cells to release insulin within minutes

AI-powered protein score predicts major atherosclerotic cardiovascular disease events

High-fat diet changes gut bacteria, bile acids, and increases colorectal cancer risk

Genetically diverse mouse models offer new insights into Alzheimer's disease

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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