Cell Signaling News and Research

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Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Novel combination therapy slows cancer growth in patients with advanced solid tumors

A phase 1 clinical trial testing a novel combination therapy developed by scientists at VCU Massey Cancer Center slowed the growth of cancer in the majority of trial participants, which were patients with advanced solid tumors.

22 Jun 2016

Anti-TNF therapy offers new hope to JDM patients

The results of a UK study presented today at the European League Against Rheumatism Annual Congress showed that tumour necrosis factor inhibitor (anti-TNF) treatment is effective at improving both muscle and skin involvement in children with juvenile dermatomyositis (JDM).

13 Jun 2016

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

A new finding in the cause of Chronic Fatigue Syndrome has been identified by researchers at Griffith University who say they are getting much closer to a complete understanding of this disabling condition.

13 Jun 2016

Short-term use of opioids implicated in protracted pain, new study finds

Painkillers such as morphine, oxycodone and methadone could actually prolong and increase pain even after only a few days’ use, according to research conducted on rats by scientists at the University of Colorado Boulder in the US.

31 May 2016

Brief opioid exposure can cause increase in chronic pain

The dark side of painkillers - their dramatic increase in use and ability to trigger abuse, addiction and thousands of fatal overdoses annually in the United States is in the news virtually every day.

31 May 2016

Japanese scientists find evidence that cytokine IL-17A plays crucial role in psoriasis

Psoriasis is an inflammatory skin condition that affects some 125 million people worldwide. It is characterized by itchy, scaly skin plaques. The exact cause of psoriasis is unclear.

25 May 2016

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

Around 8,800 people in the UK are diagnosed with pancreatic cancer each year. It is known as the UK's deadliest cancer, with a survival rate of just 3 per cent. Chemotherapy and radiotherapy alone are relatively unsuccessful in treating the disease, and while surgery to remove the tumour offers the best chance of survival, most patients are diagnosed when the cancer has already spread to other organs.

25 May 2016

Researchers identify mutations that may stimulate early cancer growth in precancerous colorectal tissue

Researchers at The University of Texas MD Anderson Cancer Center have discovered mutations that may fuel early cancer growth in precancerous colorectal tissue from high-risk patients.

24 May 2016

Diets rich in fruits and vegetables can help prevent chronic inflammation

A new study by the University of Liverpool's Institute of Ageing and Chronic Disease has identified food stuffs that can help prevent chronic inflammation that contributes to many leading causes of death.

17 May 2016

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

A promising approach for watching cell signaling processes in their physiological context: Scientists visualize apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time.

11 May 2016

Better understanding of mechanisms linked to human heart valve disease

A cell-to-cell signaling network that serves as a developmental timer could provide a framework for better understanding the mechanisms underlying human heart valve disease, say University of Oregon scientists.

6 May 2016

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

University of Alabama at Birmingham researchers report the first documentation that suppressing a key cell-signaling pathway in a rat model of Parkinson's disease reduces pathogenesis. Oral administration of AZD1480 — one of the JAK/STAT pathway inhibitors generally known as Jakinibs — lessened the destructive inflammation and nerve cell degradation in the area of the brain affected by Parkinson's.

4 May 2016

Study reveals new cell-signaling pathway that detects chromosome missegregation

A recent research study at The Hormel Institute, University of Minnesota is providing insight into the regulation of chromosome segregation and the mechanisms used by cells to prevent them from forming tumors.

4 May 2016

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Radiation therapy not only kills cancer cells, but also helps to activate the immune system against their future proliferation. However, this immune response is often not strong enough to be able to cure tumours, and even when it is, its effect is limited to the area that has been irradiated.

2 May 2016

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Designing effective new drugs, especially drugs to fight cancer, demands that you know as much as you can about the molecular workings of cancer growth. Without that, it's like planning to fight a war against an enemy you've never seen.

29 Apr 2016

Scientists find way to reduce need for secondary cataract surgery

Scientists at the University of East Anglia may have found a way to prevent complications from surgery to treat cataract - the world's leading cause of blindness.

29 Apr 2016

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.

29 Apr 2016

New study explores mechanisms that control size, shape of tubular organ systems

A new study from the group of Holger Gerhardt in collaboration with Katie Bentley's Lab addresses a long standing question in the wider field of developmental biology and tissue patterning in general, and in the vascular biology field in particular: 'What are the fundamental mechanisms controlling size and shape of tubular organ systems'.

21 Apr 2016

Aspirin use linked with reduced risk of developing bile duct cancer

A team of current and former Mayo Clinic researchers has discovered that aspirin use is associated with a significantly reduced risk of developing bile duct cancer, also called cholangiocarcinoma. The results are published in Hepatology.

20 Apr 2016

Scientists identify underlying cause of immune suppression in people with high level spinal cord injuries

Scientists report in Nature Neuroscience they have identified an underlying cause of dangerous immune suppression in people with high level spinal cord injuries and they propose a possible treatment.

19 Apr 2016

Cell Signaling News and Research

Further Reading

Novel combination therapy slows cancer growth in patients with advanced solid tumors

Anti-TNF therapy offers new hope to JDM patients

Griffith researchers move one step closer to understanding cause of Chronic Fatigue Syndrome

Short-term use of opioids implicated in protracted pain, new study finds

Brief opioid exposure can cause increase in chronic pain

Japanese scientists find evidence that cytokine IL-17A plays crucial role in psoriasis

Combining vitamin A with chemotherapy may offer promise for pancreatic cancer treatment

Researchers identify mutations that may stimulate early cancer growth in precancerous colorectal tissue

Diets rich in fruits and vegetables can help prevent chronic inflammation

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

Better understanding of mechanisms linked to human heart valve disease

Oral administration of Jakinibs reduces Parkinson's disease pathogenesis in rat model

Study reveals new cell-signaling pathway that detects chromosome missegregation

Addition of L19-IL2 can increase radiation therapy-induced immune response against tumours

Predictive statistical approach opens door to development of more effective therapies for breast cancer

Scientists find way to reduce need for secondary cataract surgery

New research on EdnrB, Wnt signaling pathways could lead to therapies for skin pigment disorders

New study explores mechanisms that control size, shape of tubular organ systems

Aspirin use linked with reduced risk of developing bile duct cancer

Scientists identify underlying cause of immune suppression in people with high level spinal cord injuries

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