Craniofacial News and Research

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Enzyme called matriptase, when left to its own devices, can cause cance

Scientists at the National Institute of Dental and Craniofacial Research (NIDCR) and colleagues report in animal studies that a single, scissor-like enzyme called matriptase, when left to its own devices, can cause cancer.

16 Aug 2005

Plastic surgery to restore facial defects helps give mentally disabled children a better lease on life

Reconstructing severe facial deformities in children with mental disabilities can be a hard decision for parents. Insurance companies may consider some operations to be only for cosmetic purposes and refuse to cover them.

2 Aug 2005

New finding has potentially major implications for anti-angiogenic therapy

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR) have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis.

18 Jul 2005

Extraordinary number of genes are required for prenatal mammalian development

A team of scientists led by Cornell University's Dr. John Schimenti reports today that an extraordinary number of genes are required for prenatal mammalian development. The researchers estimate that up to 19% of all genes are vital for embryogenesis in mice.

17 Jul 2005

Dental X-rays effectively identify stroke risk

General dentists from across the United States exchanged vital information today showing that dental X-rays, known as panoramic radiographs, used for oral health examinations, are effective in detecting some cases of clinically significant carotid artery stenosis, or blockages in the carotid artery, which can potentially lead to stroke.

15 Jul 2005

Global research network needed if scientists are ever going to understand and prevent cleft palate

Professor Bill Shaw, of The University of Manchester, says the complexity of craniofacial anomalies, like cleft lip and palate, means no one country, let alone institution, has the necessary expertise and resources to find all the answers to these distressing conditions.

From The University of Manchester 11 May 2005

A simple spit test could predict cancers

In future scientists say, a test as simple as spitting into a collection tube or cup might be a screening test for breast cancer and the early detection of other tumours.

19 Apr 2005

Fifteen-year hunt uncovers gene behind pseudothalidomide syndrome

A team of scientists from Colombia, the United States and elsewhere has successfully completed a 15-year-plus search for the genetic problems behind the very rare Roberts syndrome, whose physical manifestations often include cleft lip and palate and shortened limbs that resemble those of babies whose mothers took thalidomide during pregnancy.

11 Apr 2005

Seven-year research project to expand the evidence base in dentistry

Washington Dental Service, the University of Washington School of Dentistry and the School of Dentistry at Oregon Health Sciences University are partnering in a seven-year research project to expand the evidence base in dentistry.

5 Apr 2005

Poor oral health can affect newborn

A study published recently in the Journal of Periodontology has found that pregnant women with tooth decay are at risk for delivering Preterm Low Birth Weight (PLBW) babies.

23 Mar 2005

Dental researchers map the gene that causes dentinogenesis imperfecta

Dental researchers at The University of Texas Health Science Center are the first in the world to successfully map the gene that causes dentinogenesis imperfecta (DGI) Type III, a disease that affects tooth density and color and over time can cause teeth to wear to the gum line.

16 Mar 2005

Radiography used to identify teens with sleep apnea

Fifteen percent of all teenagers in the United States undergo orthodontic treatment. Craniofacial Risk Index (CRI) scores, calculated from the radiographs routinely obtained on all orthodontic patients, correctly classified 80% of apneic and 78% of non-apneic adult snorers into high-and low-Respiratory Disturbance Index (RDI) groups.

14 Mar 2005

Dental medicine is on the brink of profound change

Advances in stem cell biology will improve our understanding of degenerative diseases and assist in developing therapies for replacing damaged or diseased parts/tissues.

9 Mar 2005

Children can benefit from surgery for sleep apnea

Times have changed. Within the last ten years, the primary reason that children have had surgery to remove their tonsils and adenoids is not because of infection. Instead, up to 90 percent of the adenotonsillectomy surgeries are to correct obstructive sleep apnea (OSA).

1 Mar 2005

Scientists gain new insight into DiGeorge syndrome

A collaboration of European scientists has uncovered new insight into the most common chromosomal microdeletion syndrome in humans.

28 Feb 2005

Simple saliva test can predict whether children will get cavities

A simple saliva test can predict for the first time whether children will get cavities, how many cavities they will get and even which teeth are most vulnerable, USC researchers say.

23 Feb 2005

Link between heart disease and periodontal bacteria

Researchers report this week that older adults who have higher proportions of four periodontal-disease-causing bacteria inhabiting their mouths also tend to have thicker carotid arteries, a strong predictor of stroke and heart attack.

7 Feb 2005

Gene therapy helps generate bone around dental implants

A University of Michigan research team has found that introducing a growth factor protein into a mouth wound using gene therapy helped generate bone around dental implants, according to a new paper in the February issue of the journal Molecular Therapy.

3 Feb 2005

Physical traits, genetic test help with early diagnosis of aneurysm syndrome

A research team led by Johns Hopkins doctors has defined the physical traits and genetic basis of a new aortic aneurysm syndrome that is extremely aggressive and can cause death in early childhood. Early diagnosis of the syndrome and rapid surgical repair of the swollen aorta can save lives, the researchers report in the Jan. 30 advance online section of Nature Genetics.

30 Jan 2005

Distraction osteogenesis procedure may be a feasible and effective method to repair cleft palate in the future

Results from a Mayo Clinic laboratory study in animals suggest that using distraction osteogenesis, a procedure that uses the mechanical force of an appliance to lengthen soft tissue and bone, may be a feasible and effective method to repair cleft palate in the future.

24 Jan 2005