Gastrointestinal Tract News and Research

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Oral apixaban as effective as dalteparin for treating blood clots in people with cancer

For people with cancer, the oral blood thinner apixaban is at least as effective as dalteparin, a low molecular weight heparin given by injection, in preventing a repeat venous thromboembolism (VTE), or blood clot, with no excess in major bleeding events, according to Phase 3 trial results presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology.

30 Mar 2020

Taking ticagrelor alone better for patients with complex heart disease

Patients with complex heart disease who stopped taking aspirin three months after the insertion of one or more coronary stents and then took the anti-platelet medication ticagrelor alone for a year had fewer episodes of bleeding and no increase in heart attacks, stroke or other adverse events caused by blockages in the arteries, compared with patients who took both aspirin and ticagrelor over the same period.

30 Mar 2020

Treatment with ticagrelor alone reduces adverse events in patients with diabetes

Patients with diabetes who stopped taking aspirin three months after the insertion of a coronary stent and then took the anti-platelet medication ticagrelor alone for a year had fewer episodes of bleeding and no increase in heart attacks, stroke or other adverse events caused by blockages in the arteries, compared with patients who took both aspirin and ticagrelor for a year.

30 Mar 2020

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

Researchers at the University of Texas Southwestern Medical Center and University of Chicago have discovered that bacteria that usually live in the gut can accumulate in tumors and improve the effectiveness of immunotherapy in mice.

10 Mar 2020

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

Could the response to cancer immunotherapy depend on bacteria that originate in the gut and travel to the tumor?

7 Mar 2020

Researchers detect a novel cause of acquired lipodystrophy

Nonalcoholic fatty liver disease (NAFLD) is mostly diagnosed in overweight and obese people. However, severe forms of NAFLD can also be detected in rare genetic diseases such as lipodystrophy or in patients with HIV, putting them at a high risk for developing liver failure, diabetes and cardiovascular diseases.

3 Mar 2020

$Investigational drug reduces heartburn severity in patients with refractory GERD$

Investigational drug reduces heartburn severity in patients with refractory GERD

An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests.

26 Feb 2020

Woman's bladder produces alcohol – a rare medical condition

A 61-year-old woman was set for a liver transplant but was denied due to a high level of alcohol in her system. Her urine contained alcohol, which is unlikely unless someone has consumed large amounts of it.

25 Feb 2020

Immunotherapy drug combination effective for patients with fast-growing neuroendocrine tumors

Many patients with rare, fast-growing neuroendocrine tumors respond well to a common immunotherapy drug combination, according to the first peer-reviewed publication out of DART, short for Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors, a unique rare cancer clinical trial.

24 Feb 2020

DuPont Nutrition & Biosciences partners with microbiome specialist MRM Health

DuPont Nutrition & Biosciences today announced a collaboration with the MRM Health NV, a biopharmaceutical company, focused on the discovery and development of innovative therapeutics based on the human microbiome.

From DuPont 19 Feb 2020

Bacterial viruses in intestinal tracts of children may play a role in stunting

New research spearheaded by McGill University has discovered that bacteriophages (viruses that infect bacteria) found in the intestinal tracts of children may play a role in childhood stunting, a significant impediment to growth that affects 22% of children under the age of five around the world.

12 Feb 2020

Georgia State researcher receives $1.67 million federal grant to study gut immunity

Dr. Tim Denning, professor and associate director of the Institute for Biomedical Sciences at Georgia State University, has received a four-year, $1.67 million federal grant to study how an immunological pathway influences inflammatory signaling in the intestine that can lead to chronic human diseases such as inflammatory bowel disease.

9 Feb 2020

Titanium nanoparticles found in coal smog and ash can cause lung damage in mice

Virginia Tech scientists have discovered that incredibly small particles of an unusual and highly toxic titanium oxide found in coal smog and ash can cause lung damage in mice after a single exposure, with long-term damage occurring in just six weeks.

5 Feb 2020

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of foreign antigens, the major burden of which is in the form of the microbiota newly colonizing the gastrointestinal tract.

24 Jan 2020

Lung microbiome of critically ill patients is predictive of clinical outcomes

Changes in the lung microbiome may help predict how well critically ill patients will respond to care, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

21 Jan 2020

Scientists develop capsule shell composition for enzyme needed to treat phenylketonuria

IKBFU scientists developed the composition of the capsule shell for the enzyme needed in the treatment of a hereditary disease called "phenylketonuria".

21 Jan 2020

New analysis method shows how the brain regulates its signals using glutamate

Researchers at Chalmers University of Technology and Gothenburg University in Sweden have achieved something long thought almost impossible - counting the molecules of the neurotransmitter glutamate released when a signal is transferred between two brain cells. With a new analysis method, they showed that the brain regulates its signals using glutamate in more ways than previously realised.

21 Jan 2020

Gastrointestinal Tract News and Research

Oral apixaban as effective as dalteparin for treating blood clots in people with cancer

Taking ticagrelor alone better for patients with complex heart disease

Treatment with ticagrelor alone reduces adverse events in patients with diabetes

Gut bacteria can accumulate in tumors and improve effectiveness of cancer immunotherapy

Gut bacteria can boost effectiveness of cancer immunotherapy, mice study suggests

Researchers detect a novel cause of acquired lipodystrophy

Investigational drug reduces heartburn severity in patients with refractory GERD

Woman's bladder produces alcohol – a rare medical condition

Immunotherapy drug combination effective for patients with fast-growing neuroendocrine tumors

DuPont Nutrition & Biosciences partners with microbiome specialist MRM Health

Bacterial viruses in intestinal tracts of children may play a role in stunting

Georgia State researcher receives $1.67 million federal grant to study gut immunity

Titanium nanoparticles found in coal smog and ash can cause lung damage in mice

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Lung microbiome of critically ill patients is predictive of clinical outcomes

Scientists develop capsule shell composition for enzyme needed to treat phenylketonuria

New analysis method shows how the brain regulates its signals using glutamate

Team finds a way to removes GI device without using endoscopy

Walnuts may be a heart- and gut-healthy snack

Boston researchers develop novel approach to generate intestinal organoids in vitro

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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