Enzyme News and Research

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Targeting Sirt-1 enzyme shows promise in controlling graft-vs-host disease

Bone marrow transplant offers patients with leukemia and lymphoma a potentially curative treatment. Bone marrow from the donor contains healthy immune cells, whose mission is to protect the body from invaders.

28 Jan 2019

Scientists use integrative approach to study how COQ9 binds and interacts with lipids

The synthesis and transport of biological lipids across the mostly water-filled interior of the cell is a longstanding problem in biology.

28 Jan 2019

Low doses of anti-HIV drug appear to reduce tau protein in neurons of Alzheimer’s patients

The accumulation of amyloid beta plaques and tangles of a protein called tau in the brain are hallmarks of Alzheimer's disease.

27 Jan 2019

Regular use of aspirin may help some patients survive head and neck cancer

Regular use of aspirin or other nonsteroidal anti-inflammatory drugs may help some patients with head and neck cancer survive the disease, according to a study led by Professor Jennifer Grandis at the University of California, San Francisco.

27 Jan 2019

NIH researchers discover that anti-flu antibodies can inhibit two different viral proteins

Researchers from the National Institutes of Health have discovered that antibodies that may form the basis of a universal flu vaccine inhibit a second viral protein in addition to the one that they bind.

25 Jan 2019

Excessive suppression of GSK3 enzyme can trigger renal failure, finds study

Scientists have identified an enzyme that is a "master regulator" of kidney function that if excessively suppressed, can trigger renal failure. Their findings have implications for the use of existing drugs and the development of new pharmaceuticals.

24 Jan 2019

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Although many people are aware that chromosomal damage and shortening contribute to the aging process, understanding how chromosomal defects occur is about more than just finding a way to turn back the clock. Large changes in the structure of chromosomes, known as gross chromosomal rearrangements, can result in cell death or genetic diseases such as cancer.

24 Jan 2019

Enzyme that breaks down amino acids plays key role in promoting cellular senescence

Permanently arrested cell growth is known as "cellular senescence", and the accumulation of senescent cells may be one cause of aging in our bodies. Japanese researchers have discovered that a certain enzyme in our bodies promotes cellular senescence by producing reactive oxygen species.

24 Jan 2019

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Using a new epigenetics-based approach, scientists have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease.

22 Jan 2019

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Researchers at A*STAR's Singapore Bioimaging Consortium have discovered that branched-chain amino acids in tumors can be targeted to prevent and treat cancer. Together with collaborators from the United States and National Cancer Centre Singapore, they found that some cancers potently suppress the catabolism (breakdown) of BCAAs.

21 Jan 2019

Fiderstat could be used as chemopreventative drug for intestinal cancers caused by APC gene mutations

Colorectal Cancer has now become one of the leading causes of death. Studies indicate that smoking, low physical activities and high-fat diet are a major risk factor for colorectal cancer.

21 Jan 2019

Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS

The Icahn School of Medicine at Mount Sinai has entered into two exclusive licenses to develop the drug pentosan polysulfate sodium for and ReqMed Company, Ltd. of Japan.

21 Jan 2019

Study shows how gut bacteria affect the treatment of Parkinson's disease

Patients with Parkinson's disease are treated with levodopa, which is converted into dopamine, a neurotransmitter in the brain. In a study published on 18 January in the journal Nature Communications, scientists from the University of Groningen show that gut bacteria can metabolize levodopa into dopamine.

18 Jan 2019

New enzyme biomarker test indicates diseases and bacterial contamination

Researchers at Queen's University Belfast have developed a highly innovative new enzyme biomarker test that has the potential to indicate diseases and bacterial contamination saving time, money and possibly lives.

18 Jan 2019

Blood vessels can now be created perfectly in a petri dish

Researchers have now successfully created perfect blood vessels in the labs and this may be a huge step in benefitting people with diabetes and other conditions. The report of the procedure appears in a study titled, “Human blood vessel organoids as a model of diabetic vasculopathy,” published in the latest issue of the journal Nature.

17 Jan 2019

The cytoskeleton of neurons found to play role in Alzheimer's disease

A researcher at the UPV/EHU has participated in a study describing what it is during the early stages of Alzheimer's that triggers the loss of dynamics and subsequent impairment of the dendritic spines, the compartments of the neurons responsible for receiving nerve impulses from other neurons.

17 Jan 2019

Yeast model may pave way for development of novel therapies for metabolic disorders

There are hundreds of metabolic disorders -- including phenylketonuria, tyrosinemia, maple syrup urine disease and homocystinuria.

17 Jan 2019

Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli

Researchers from North Carolina State University have developed an artificial enzymatic pathway for synthesizing isoprenoids, or terpenes, in E. coli.

17 Jan 2019

Researchers cultivate vascular organoids that perfectly mimic human blood vessels

For the first time, researchers have successfully cultivated “vascular organoids” in a petri dish that perfectly mimic real human blood vessels.

16 Jan 2019

Salk team uses new model to study health effects of AMP-activated protein kinase

The metabolic protein AMPK has been described as a kind of magic bullet for health. Studies in animal models have shown that compounds that activate the protein have health-promoting effects to reverse diabetes, improve cardiovascular health, treat mitochondrial disease--even extend life span.

16 Jan 2019

Enzyme News and Research

Targeting Sirt-1 enzyme shows promise in controlling graft-vs-host disease

Scientists use integrative approach to study how COQ9 binds and interacts with lipids

Low doses of anti-HIV drug appear to reduce tau protein in neurons of Alzheimer’s patients

Regular use of aspirin may help some patients survive head and neck cancer

NIH researchers discover that anti-flu antibodies can inhibit two different viral proteins

Excessive suppression of GSK3 enzyme can trigger renal failure, finds study

Researchers uncover new role of heterochromatin in maintaining chromosomal integrity

Enzyme that breaks down amino acids plays key role in promoting cellular senescence

Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease

Branched-chain amino acids in tumors can be targeted to prevent and treat cancer

Fiderstat could be used as chemopreventative drug for intestinal cancers caused by APC gene mutations

Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS

Study shows how gut bacteria affect the treatment of Parkinson's disease

New enzyme biomarker test indicates diseases and bacterial contamination

Blood vessels can now be created perfectly in a petri dish

The cytoskeleton of neurons found to play role in Alzheimer's disease

Yeast model may pave way for development of novel therapies for metabolic disorders

Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli

Researchers cultivate vascular organoids that perfectly mimic human blood vessels

Salk team uses new model to study health effects of AMP-activated protein kinase

Understanding the DNA Damage Response in Innate Immunity eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo