Genes News and Research

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Study modeling tumor evolution reveals a central tradeoff that could be exploited for cancer treatment

Though the mutations accumulated by cancer cells occur more or less randomly, certain regions of genes essential to cancer growth appear to be more frequently mutated than others in established tumors.

11 May 2022

Review portrays clinical journey of messenger RNA vaccines and mRNA-based therapies

Researchers reviewed messenger ribonucleic acid (mRNA) technology and highlighted its clinical applications.

11 May 2022

COVID-19-induced non-cell-autonomous anosmia

Researchers reported that SARS-CoV-2-induced anosmia was based on non-cell-independent processes.

11 May 2022

Deep learning reveals genetic determinants of COVID-19-associated mortality

In a recent study posted to the medRxiv* preprint server, researchers applied deep learning methods and identified genetic variants linked to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-caused mortality.

11 May 2022

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

An article published in the journal Molecular Psychiatry reveals the molecular mechanisms to explain how the YWHAZ gene –related to psychiatric and neurological disorders such as autism and schizophrenia– can alter the neurodevelopmental process.

10 May 2022

New Clinical Practice Resource released to guide the treatment of patients with hearing loss

The American College of Medical Genetics and Genomics has released a new Clinical Practice Resource that will help direct the treatment of patients with hearing loss: "Clinical Evaluation and Etiologic Diagnosis of Hearing Loss: A Clinical Practice Resource of the American College of Medical Genetics and Genomics."

10 May 2022

Diet with higher amounts of soluble fiber may be a solution to reduce antimicrobial resistance

Healthy adults who eat a diverse diet with at least 8-10 grams of soluble fiber a day have fewer antibiotic-resistant microbes in their guts, according to a study published by Agricultural Research Service scientists and their colleagues in mBio.

10 May 2022

Study finds link between hippocampal defects and intellectual disability in children with Joubert Syndrome

An important link has been found between the intellectual disability experienced by children with the rare disease Joubert Syndrome (JS) and defects in the hippocampus.

10 May 2022

Better understanding of hybrid parasite strains could improve Chagas disease diagnosis

Researchers at Karolinska Institutet in Sweden have mapped how the parasite Trypanosoma cruzi forms new variants that are more effective at evading the immune system and causing disease.

10 May 2022

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

UNC School of Medicine Scientists have shown for the first time that postnatal gene therapy may be able to prevent or reverse many deleterious effects of a rare genetic disorder called Pitt-Hopkins syndrome.

10 May 2022

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Inhibitors of the protein EZH2 are effective against cancers with SMARCB1 mutations such as rhabdoid tumors in children.

9 May 2022

Researchers make breakthrough in overcoming drug resistance in a rare, devastating blood cancer

South Australian scientists have made a significant breakthrough in overcoming drug resistance in acute myeloid leukemia (AML), a rare and devastating blood cancer that kills most patients within a few years.

9 May 2022

Research suggests a new approach to treating Glioblastoma Multiforme in adults

Findings from a seven-year research project suggests that there could be a new approach to treating one of the most common and devasting forms of brain cancer in adults - Glioblastoma Multiforme (GBM).

9 May 2022

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

Researchers developed a novel protocol to examine dopamine (DA) neurons extracted from Parkinson’s disease (PD) patients using single-cell genomic sequencing.

9 May 2022

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

In this interview, we speak to Steffi Oesterreich, PH.D., from the University of Pittsburgh, about how new insights into a gene mutation present in 20-30% of breast cancer recurrences may have a silver lining, leading to novel treatment opportunities.

9 May 2022

Evaluating the Role of Automated LabTech Instruments within Research

In this interview, we speak to Günter Tenzler, founder and CEO of INHECO, about their automated labtech instruments and their role within scientific research.

From Society for Laboratory Automation and Screening (SLAS) 9 May 2022

What can chimpanzees tell us about cancer propensity in humans?

A recent study published in the renowned journal Cell Reports finds evidence for reduced functional activity of certain human cancer genes (such as breast cancer 2 gene or BRCA2), following the divergence from the chimpanzee-human last common ancestor.

9 May 2022

Genes News and Research

Study modeling tumor evolution reveals a central tradeoff that could be exploited for cancer treatment

Review portrays clinical journey of messenger RNA vaccines and mRNA-based therapies

COVID-19-induced non-cell-autonomous anosmia

Deep learning reveals genetic determinants of COVID-19-associated mortality

Deficiency of YWHAZ gene alters neurodevelopmental process in zebrafish

New Clinical Practice Resource released to guide the treatment of patients with hearing loss

Diet with higher amounts of soluble fiber may be a solution to reduce antimicrobial resistance

Study finds link between hippocampal defects and intellectual disability in children with Joubert Syndrome

Better understanding of hybrid parasite strains could improve Chagas disease diagnosis

Postnatal gene therapy may be able to prevent or reverse deadly effects of Pitt-Hopkins syndrome

Novel drug target may help overcome resistance to EZH2 inhibitors in SMARCB1 mutated cancers

Researchers make breakthrough in overcoming drug resistance in a rare, devastating blood cancer

Research suggests a new approach to treating Glioblastoma Multiforme in adults

Single-cell genomic sequencing identifies a subpopulation of human dopamine neurons that degenerates in Parkinson’s disease

How new Insights into ESR1 Mutant Breast Cancers may lead to Novel Therapy Targets

Evaluating the Role of Automated LabTech Instruments within Research

What can chimpanzees tell us about cancer propensity in humans?

Changes in gut microbiome impact depression

New tool can help researchers interpret the clinical significance of somatic mutations in cancer

Inversions in the human genome found to be more common than previously thought

eBook: Using iPSCs models for human disease research and drug discovery eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo