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Study shows link between liver-produced molecules, pneumonia susceptibility during sepsis

New evidence highlights the importance of the liver in immunity against bacterial pneumonia. The study is the first of its kind to directly show such a link between liver-produced molecules and pneumonia susceptibility during sepsis.

31 Jul 2015

Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

Roche today announced it has submitted the cobas EGFR Mutation Test v2 for Premarket Approval (PMA) to the U.S. Food and Drug Administration, as a companion diagnostic test for AZD9291, an AstraZeneca investigational therapy for non-small cell lung cancer patients with an acquired resistant mutation.

30 Jul 2015

Intraoperative fluorescent imaging detects lung adenocarcinoma during pulmonary resection

More than 80,000 people undergo resection of a pulmonary tumor each year, and currently the only method to determine if the tumor is malignant is histologic analysis. A new study reports that a targeted molecular contrast agent can be used successfully to cause lung adenocarcinomas to fluoresce during pulmonary surgery.

30 Jul 2015

New national survey finds lack of COPD knowledge among patients

In a new national survey of chronic obstructive pulmonary disease (COPD) patients, Health Union reveals a surprising lack of awareness of risk factors and knowledge of diagnosis stage among patients. Results demonstrate a severe impact on quality of life, employment, and ability to afford treatment.

30 Jul 2015

New set of clinical practice guidelines released to address temperature management during open heart surgery

The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of ExtraCorporeal Technology have released a set of clinical practice guidelines to address management of a patient's temperature during open heart surgery. The guidelines appear in the August issue of The Annals of Thoracic Surgery and were published simultaneously in two other journals.

30 Jul 2015

Patients undergoing surgery for lung cancer wait too long to receive treatment, skip vital diagnostic steps

Patients undergoing surgery for lung cancer may wait too long to receive treatment, and too many patients skip vital diagnostic steps that are needed to help determine the best possible treatment, according to an article in the August 2015 issue of The Annals of Thoracic Surgery.

30 Jul 2015

New study reports creation of genetic porcine model of cancer

With many types of cancers, early detection offers the best hope for survival. However, research into new early-detection screenings, as well as possible interventional radiology and surgical treatments, has been hindered by the lack of a large animal model that would accurately reflect the types of cancers seen in human cells.

30 Jul 2015

UT Southwestern's Pulmonary Hypertension Program continues to grow in the U.S.

When Derrik Neal began having trouble breathing, he initially assumed it was because he was overweight. But after blacking out several times, he learned he had idiopathic pulmonary hypertension. Survival rates at the time he was diagnosed were five years or less - three or less if undetected.

30 Jul 2015

$UO-led effort on fractal-based nerve connections granted U.S. patent$

UO-led effort on fractal-based nerve connections granted U.S. patent

Richard Taylor's vision of using artificial fractal-based implants to restore sight to the blind -- part of a far-reaching concept that won an innovation award this year from the White House -- is now covered under a broad U.S. patent.

29 Jul 2015

New type of mycovirus can cause aspergillosis in humans

Researchers, led by Dr Robert Coutts, Leverhulme Research Fellow from the School of Life and Medical Sciences at the University of Hertfordshire, and Dr Ioly Kotta-Loizou, Research Associate at Imperial College, have discovered a completely novel type of mycovirus.

29 Jul 2015

New tool combines drugs to target kinase dependency in cancer

Targeted therapies attack a cancer's genetic sensitivities. However, it can be difficult to discover the genetics driving a patient's cancer, and the effects of drugs designed to target a genetic abnormality often go beyond their intended target alone. The result is threefold: sometimes a drug is prescribed to treat a target that proves to be irrelevant to the disease, sometimes an existing drug could be used to treat a cancer for which there is no approved targeted therapy, and sometimes a combination of targeted treatments could be used to simultaneously silence more than one genetic cause of a patient's cancer.

29 Jul 2015

Moerae announces initiation of second MMI-0100 Phase 1 clinical trial for pulmonary disorders

Moerae Matrix Inc. announced today the initiation of its second Phase 1 clinical trial with MMI-0100, a first-in-class inhibitor of MAPKAP kinase 2 (MK2) that is being developed for pulmonary disorders characterized by inflammation and fibrosis. The study, conducted in the United Kingdom, is a double-blind, two-way cross-over design lipopolysaccharide (LPS) challenge study further evaluating the safety and tolerability of MMI-0100 when given via inhalation to healthy subjects who smoke.

29 Jul 2015

Two-step regimen of experimental MERS vaccines show promise in mice

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. Vaccinated mice produced broadly neutralizing antibodies against multiple strains of the MERS coronavirus (MERS-CoV), while vaccinated macaques were protected from severe lung damage when later exposed to MERS-CoV.

29 Jul 2015

Moffitt researchers find cancer healthcare disparities in LGBTQ community

The Lesbian, Gay, Bisexual, Transgender/Transsexual, Queer/Questioning (LGBTQ) community is a growing and medically-underserved minority population in the United States, with 3 to 12 percent of the population estimated to identify as LGBTQ.

29 Jul 2015

Researchers develop dynamic functional mouse model for lung injury repair

Researchers at Children's Hospital Los Angeles and The Saban Research Institute of CHLA have created a dynamic functional mouse model for lung injury repair, a tool that will help scientists explain the origins of lung disease and provide a system by which new therapies can be identified and tested.

29 Jul 2015

Research brief provides clinical validation of LOXO-101 Phase 1 trial for treatment of TRK fusion cancer

The University of Colorado Cancer Center and Loxo Oncology, Inc., a biopharmaceutical company focused on the discovery, development and commercialization of targeted cancer therapies, today announced the publication of a research brief in the online edition of the journal Cancer Discovery, describing the first patient with a tropomyosin receptor kinase fusion cancer enrolled in the Phase 1 dose escalation trial of LOXO-101, the only selective TRK inhibitor in clinical development.

28 Jul 2015

VolitionRx selects Global Specimen Solutions to support U.S. market entry of NuQ colorectal cancer tests

VolitionRx Limited, a life sciences company focused on developing blood-based diagnostic tests for a broad range of cancer types and other conditions, today announced that it has engaged the services of a specialty specimen management clinical research organization, Global Specimen Solutions, Inc., to support initial U.S. market entry of its NuQ colorectal cancer tests.

28 Jul 2015

Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

The University of Colorado Cancer Center and Loxo Oncology, Inc., a biopharmaceutical company focused on the discovery, development and commercialization of targeted cancer therapies, today announced the publication of a research brief in the online edition of the journal Cancer Discovery, describing the first patient with a tropomyosin receptor kinase (TRK) fusion cancer enrolled in the Phase 1 dose escalation trial of LOXO-101, the only selective TRK inhibitor in clinical development.

28 Jul 2015

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis is a very aggressive form of pulmonary fibrosis and has a particularly poor prognosis. This fatal disease, for which so far no causal therapies exist, is characterized by a massive deposition of connective and scar tissue in the lung, which leads to a progressive loss of lung function and ultimately death.

28 Jul 2015

Biologists identify genetic mechanisms behind anti-inflammatory impact of cortisone

There's no time to lose when an emergency doctor diagnoses „Shock lung!" at the accident scene. What physicians know as "acute lung injury" (ALI) otherwise leads to death by suffocation without immediate treatment.

25 Jul 2015

Lungs News and Research

Study shows link between liver-produced molecules, pneumonia susceptibility during sepsis

Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

Intraoperative fluorescent imaging detects lung adenocarcinoma during pulmonary resection

New national survey finds lack of COPD knowledge among patients

New set of clinical practice guidelines released to address temperature management during open heart surgery

Patients undergoing surgery for lung cancer wait too long to receive treatment, skip vital diagnostic steps

New study reports creation of genetic porcine model of cancer

UT Southwestern's Pulmonary Hypertension Program continues to grow in the U.S.

UO-led effort on fractal-based nerve connections granted U.S. patent

New type of mycovirus can cause aspergillosis in humans

New tool combines drugs to target kinase dependency in cancer

Moerae announces initiation of second MMI-0100 Phase 1 clinical trial for pulmonary disorders

Two-step regimen of experimental MERS vaccines show promise in mice

Moffitt researchers find cancer healthcare disparities in LGBTQ community

Researchers develop dynamic functional mouse model for lung injury repair

Research brief provides clinical validation of LOXO-101 Phase 1 trial for treatment of TRK fusion cancer

VolitionRx selects Global Specimen Solutions to support U.S. market entry of NuQ colorectal cancer tests

Research brief describes enrollment of first patient with TRK fusion cancer in LOXO-101 Phase 1 trial

Scientists reveal potential therapeutic approach to idiopathic pulmonary fibrosis

Biologists identify genetic mechanisms behind anti-inflammatory impact of cortisone

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