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Hypertension drug may improve effectiveness of ovarian cancer treatment

A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cancer

16 Jan 2019

Scientists reveal key mechanism in worms that controls cell's response to stress

Scientists have revealed a key mechanism in worms that is involved in controlling the cell's response to stress, a study in eLife reports.

16 Jan 2019

FDA-approved drug hampers cancer metastasis in animal model, shows study

For cancer to spread, it needs a hospitable environment in distant organs. This fertile "soil" can provide a home to circulating malignant cells.

16 Jan 2019

Novel microfluidic device for real-time detection of cholesterol in liver-on-chip cultures

In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the Department of Biomedical Engineering at Illinois Institute of Technology, Chicago has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes.

11 Jan 2019

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse applications beyond simple DNA cutting, such as base editing and epigenetic modifications.

11 Jan 2019

Study finds specific function of HIV protein that slows viral spread in early stages of infection

A study from a Massachusetts General Hospital research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection.

11 Jan 2019

Study shows an unusual mechanism could have thwart the invasion of human genome by junk DNA

In the January 7th edition of Communications Biology, researchers at InsideOutBio argue that an unusual form of DNA with a reverse twist may have helped thwart the invasion of the human genome by junk DNA.

11 Jan 2019

Scientists pinpoint a hidden culprit in heart failure

An international research team led by scientists at the University of Alberta have pinpointed a hidden culprit that leads to dilated cardiomyopathy--a dangerous condition that accounts for 20 per cent of all cases of heart failure--which opens the door to potential new treatments that could help counter the threat.

10 Jan 2019

Drug development options diversified with new manganese catalyst

A University of Illinois team of researchers led by chemistry professor M. Christina White has developed a new manganese-based catalyst that can change the structure of druglike molecules to make new drugs, advancing the pace and efficiency of drug development.

9 Jan 2019

New mechanism of gene regulation involved in tumor progression discovered

Genes contain all the information needed for the functioning of cells, tissues, and organs in our body. Gene expression, meaning when and how are the genes being read and executed, is thoroughly regulated like an assembly line with several things happening one after another.

9 Jan 2019

Researchers find new way to reduce bleeding in patients after bariatric surgery

Rutgers researchers have found a way to reduce bleeding in patients following bariatric surgery.

9 Jan 2019

Study: Rutin found in fruits and vegetables protect mice against snake venom

Rutin, a bioflavonoid found in certain vegetables and fruits, protects mice against snake venom by minimizing bleeding and inflammation, according to a study performed at the Butantan Institute, a research institution belonging to the government of São Paulo State in Brazil.

9 Jan 2019

Study offers new insight on mechanism underlying control of gene expression

Researchers have provided new insight on the mechanism underlying the control of gene expression in all living organisms, according to a study published today in eLife.

8 Jan 2019

Genetic variations may influence whether vitamin E decreases or increases cancer risk

Almost half of all Americans take a vitamin supplement, and yet many large-scale, placebo-controlled clinical trials of various supplements have found little or no benefit.

8 Jan 2019

Essential nutrient may hold promise in the war against Alzheimer's disease

In a new study, researchers at the Biodesign Institute explore a safe and simple treatment for one of the most devastating and perplexing afflictions: Alzheimer's disease.

8 Jan 2019

Johns Hopkins researchers identify new marker for early detection of colorectal cancers

Johns Hopkins researchers have identified a protein involved in cell proliferation and the development of new blood vessels that could serve as a marker for the early detection of colorectal cancers.

7 Jan 2019

Common food additive could cause celiac disease, review says

Research suggests that celiac disease could be caused by a bacterial enzyme used to manufacture sausages, cheese, bread and other processed foods.

7 Jan 2019

Research illuminates abilities of ADAR1 to ‘hyper-mutate’ tumor suppressor RNAs in leukemia

Writing in the January 3 issue of Cancer Cell, researchers at University of California San Diego School of Medicine report that detection of "copy editing" by a stem cell enzyme called ADAR1, which is active in more than 20 tumor types, may provide a kind of molecular radar for early detection of malignancies and represent a new therapeutic target for preventing cancer cell resistance to chemotherapy and radiation.

3 Jan 2019

Scavenging molecule offers long-lasting protection against toxic nerve agents in rodents

For the first time, scientists have created a scavenging molecule that provides long-lasting preventative protection against toxic nerve agents in rodents.

3 Jan 2019

Rockefeller scientists uncover genetic mutation responsible for tuberculosis vulnerability

If you live in the United States, you are unlikely to come into contact with the microbe that causes tuberculosis. Your odds of encountering the microbe are so low, in fact, that risk factors for the disease can easily go unnoticed: If you happened to carry a gene that predisposed you to tuberculosis, you likely wouldn't know.

2 Jan 2019

Enzyme News and Research

Hypertension drug may improve effectiveness of ovarian cancer treatment

Scientists reveal key mechanism in worms that controls cell's response to stress

FDA-approved drug hampers cancer metastasis in animal model, shows study

Novel microfluidic device for real-time detection of cholesterol in liver-on-chip cultures

CRISPR-Cas9 circular permutants can sense and respond to viral proteases

Study finds specific function of HIV protein that slows viral spread in early stages of infection

Study shows an unusual mechanism could have thwart the invasion of human genome by junk DNA

Scientists pinpoint a hidden culprit in heart failure

Drug development options diversified with new manganese catalyst

New mechanism of gene regulation involved in tumor progression discovered

Researchers find new way to reduce bleeding in patients after bariatric surgery

Study: Rutin found in fruits and vegetables protect mice against snake venom

Study offers new insight on mechanism underlying control of gene expression

Genetic variations may influence whether vitamin E decreases or increases cancer risk

Essential nutrient may hold promise in the war against Alzheimer's disease

Johns Hopkins researchers identify new marker for early detection of colorectal cancers

Common food additive could cause celiac disease, review says

Research illuminates abilities of ADAR1 to ‘hyper-mutate’ tumor suppressor RNAs in leukemia

Scavenging molecule offers long-lasting protection against toxic nerve agents in rodents

Rockefeller scientists uncover genetic mutation responsible for tuberculosis vulnerability

Understanding the DNA Damage Response in Innate Immunity eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo