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Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Alnylam Pharmaceuticals a leading RNAi therapeutics company, announced today that it has initiated dosing in its Phase I clinical trial with ALN-TTRsc, an RNAi therapeutic targeting transthyretin (TTR) for the treatment of TTR-mediated amyloidosis (ATTR).

19 Mar 2013

Salivary duct access products launched by Cook Medical to offer minimally invasive options for obstructive salivary gland disease

Cook Medical has launched a suite of salivary duct access products that offer minimally invasive options for the treatment of obstructive salivary gland disease. Minimally invasive treatment of obstructive salivary gland disease can reduce the need for invasive open surgery.

18 Mar 2013

Novel therapeutic strategy for post-prostatectomy erectile dysfunction

Transplantation of mesenchymal stem cells cultivated on the surface of nanofibrous meshes could be a novel therapeutic strategy against post-prostatectomy erectile dysfunction, conclude the authors of a study which is to be presented at the 28th Annual EAU Congress later this week.

16 Mar 2013

ConservoCare obtains license options to develop nerve-block medical device for bladder control

ConservoCare, LLC, a spinoff of research at Case Western Reserve University, has obtained license options through the university's Technology Transfer Office to develop a medical device for bladder control.

16 Mar 2013

Fast-progressing hearing impairment linked to fatal Creutzfeldt-Jakob Disease

Rapid hearing loss in both ears may be a symptom of the rare but always-fatal Creutzfeldt-Jakob Disease and should be considered a reason for clinicians to test for the disorder.

15 Mar 2013

New therapeutic approach for bladder pain syndrome

Severe chronic pain associated with conditions such as bladder pain syndrome/interstitial cystitis often require the use of opioid medication, with the risk of dependency and serious adverse reactions.

15 Mar 2013

Phase 1b study of olesoxime initiated in multiple sclerosis (MS) patients

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14 Mar 2013

VCP gene mutations cause neurological conditions including IBMPFD and ALS

New research, published in Neuron, gives insight into how single mutations in the VCP gene cause a range of neurological conditions including a form of dementia called Inclusion Body Myopathy, Paget's Disease of the Bone and Frontotemporal Dementia (IBMPFD), and the motor neuron disease Amyotrophic Lateral Sclerosis (ALS).

14 Mar 2013

H1N1 flu vaccination associated with small excess risk of acquiring Guillain-Barré syndrome, but benefits outweigh risks

A meta-analysis of safety data gathered during the 2009 H1N1 vaccination programme in the US has established that the vaccination was associated with a small excess risk – about 1.6 extra cases per one million people vaccinated – of acquiring Guillain-Barré syndrome, a disorder of the nervous system which can result in temporary or more long-lasting paralysis and infrequently death. The authors conclude that the benefits of the 2009 H1N1 vaccination campaign greatly outweighed the risks.

14 Mar 2013

Stimulating brain using magnetic stimulation may improve cognitive function, say scientists

Cognitive impairments are disabling for individuals with schizophrenia, and no satisfactory treatments currently exist. These impairments affect a wide range of cognition, including memory, attention, verbal and motor skills, and IQ.

14 Mar 2013

New procedure to treat pseudotumor cerebri

A team of interventional neuroradiologists and neurosurgeons at Johns Hopkins reports wide success with a new procedure to treat pseudotumor cerebri, a rare but potentially blinding condition marked by excessive pressure inside the skull, caused by a dangerous narrowing of a vein located at the base of the brain.

13 Mar 2013

MGH investigators identify new disease that causes widespread chronic pain in children

Massachusetts General Hospital (MGH) investigators have described what may be a newly identified disease that appears to explain some cases of widespread chronic pain and other symptoms in children and young adults.

13 Mar 2013

B cells regulate obesity-associated inflammation and T2D through two specific mechanisms

New research from Boston University School of Medicine (BUSM) reveals that B cells regulate obesity-associated inflammation and type 2 diabetes through two specific mechanisms.

13 Mar 2013

Combination of INF and glatiramer acetate does not reduce MS progression

A recent clinical trial found that interferonβ-1a (INF) and glatiramer acetate (GA), two of the most commonly prescribed drugs for multiple sclerosis (MS), provide no additional clinical benefit when taken together.

12 Mar 2013

Buphenyl may protect memory and prevent progression of Alzheimer's

Buphenyl, an FDA-approved medication for hyperammonemia, may protect memory and prevent the progression of Alzheimer's disease.

12 Mar 2013

Researchers develop new approach to screening potential treatments for Alzheimer's disease

According to a 2012 World Health Organization report, over 35 million people worldwide currently have dementia, a number that is expected to double by 2030 (66 million) and triple by 2050 (115 million).

11 Mar 2013

Researchers identify new mechanism in onset of motor neuron diseases

The British astrophysicist Stephen Hawking is likely to be the world's most famous person living with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. ALS is a progressive disease affecting motor neurons, nerve cells that control muscle function, and nearly always leads to death.

11 Mar 2013

GENIE public engagement lectures to take place on Mar. 12

If you have ever wondered why a curry feels hot, or about the risks of inherited disease, two eminent experts will give you an answer at a University of Leicester public event.

8 Mar 2013

Boosting hypocretin could elevate both mood and alertness in humans

What makes us happy? Family? Money? Love? How about a peptide? The neurochemical changes underlying human emotions and social behavior are largely unknown. Now though, for the first time in humans, scientists at UCLA have measured the release of a specific peptide, a neurotransmitter called hypocretin, that greatly increased when subjects were happy but decreased when they were sad.

8 Mar 2013

Researchers identify role of Merlin in regulating integrity of axons

One in 25,000 people worldwide is affected by neurofibromatosis type 2 (NF2), a condition where the loss of a tumour suppressor called Merlin results in multiple tumours in the brain and nervous system.

7 Mar 2013

Nerve News and Research

Alnylam begins dosing in Phase I clinical trial with ALN-TTRsc for treatment of ATTR

Salivary duct access products launched by Cook Medical to offer minimally invasive options for obstructive salivary gland disease

Novel therapeutic strategy for post-prostatectomy erectile dysfunction

ConservoCare obtains license options to develop nerve-block medical device for bladder control

Fast-progressing hearing impairment linked to fatal Creutzfeldt-Jakob Disease

New therapeutic approach for bladder pain syndrome

Phase 1b study of olesoxime initiated in multiple sclerosis (MS) patients

VCP gene mutations cause neurological conditions including IBMPFD and ALS

H1N1 flu vaccination associated with small excess risk of acquiring Guillain-Barré syndrome, but benefits outweigh risks

Stimulating brain using magnetic stimulation may improve cognitive function, say scientists

New procedure to treat pseudotumor cerebri

MGH investigators identify new disease that causes widespread chronic pain in children

B cells regulate obesity-associated inflammation and T2D through two specific mechanisms

Combination of INF and glatiramer acetate does not reduce MS progression

Buphenyl may protect memory and prevent progression of Alzheimer's

Researchers develop new approach to screening potential treatments for Alzheimer's disease

Researchers identify new mechanism in onset of motor neuron diseases

GENIE public engagement lectures to take place on Mar. 12

Boosting hypocretin could elevate both mood and alertness in humans

Researchers identify role of Merlin in regulating integrity of axons

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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