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Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

Research in recent years has demonstrated the diverse roles that gut bacteria can play in health and disease, but what about contributions from viruses, which, like bacteria, perpetually reside within the human intestine?

8 Apr 2022

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

On Thursday, April 7, the Centers for Medicare and Medicaid (CMS) formalized its plan to cover the anti-amyloid drug Aduhelm only for patients enrolled in clinical trials.

8 Apr 2022

Researchers discover new mechanisms for bone loss in gum disease

Tokyo University of Agriculture and Technology researchers reported on a new discovery regarding the mechanisms for bone loss in gum disease (periodontitis). They found that double stranded RNA molecules can activate the immune system response that leads to deterioration of bone.

8 Apr 2022

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

New findings from the ongoing Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study suggest that certain rheumatoid arthritis drugs may lower incidence of Alzheimer's disease and related dementias in people with cardiovascular disease.

8 Apr 2022

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

A new study demonstrated that vascular inflammation leads to heightened SARS-CoV-2 infection in perivascular cells.

8 Apr 2022

Depressive disorders are associated with general increase in the deformability of immune cells

A recent study by the TU Dresden and the University of Zurich in cooperation with the Max Planck Institute for the Science of Light establishes for the first time a link between depressive disorders and mechanical characteristics of all major blood cell types.

8 Apr 2022

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Despite guidelines that call for early and aggressive treatment of rheumatoid arthritis, a new study suggests many older adults are not prescribed disease-modifying medications for their inflammatory autoimmune disease.

8 Apr 2022

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

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8 Apr 2022

Yale researchers discover immune response pathway that leads to severe COVID-19

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

7 Apr 2022

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research.

7 Apr 2022

Researchers reveal why people with allergic asthma are protected from severe COVID

The vast majority of people infected with the omicron variant of SARS-CoV-2 experience mild cold-like symptoms, moderate flu-like symptoms, or no symptoms at all, but the virus is so transmissible that it still spread deep into lung tissue to cause severe disease and death in thousands of people in the United States in 2022 alone.

7 Apr 2022

Inflammation News and Research

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Imbalances in the intestinal virome may promote inflammatory bowel disease, research shows

ADDF supports the need to gather more evidence about clinical effectiveness of anti-amyloid drug

Researchers discover new mechanisms for bone loss in gum disease

Certain antirheumatic drugs may lower incidence of Alzheimer's and related dementias in people with cardiovascular disease

Substantial SARS-CoV-2 infection in perivascular cells of inflamed blood vessels

Depressive disorders are associated with general increase in the deformability of immune cells

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

Yale researchers discover immune response pathway that leads to severe COVID-19

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

Researchers reveal why people with allergic asthma are protected from severe COVID

Insomnia common in heart disease patients and linked with subsequent cardiovascular events

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Study explores incidence of cardiac impairment a year after SARS-CoV-2 infection

Insights into the pathophysiology of NeuroCOVID

The association of lipid levels with the risk of COVID-19 infection, hospitalization, disease severity, and mortality

Emergency C-section may compromise development and long-term health of babies

Study to investigate new microbial-derived biomarkers for early detection of lung cancer

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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