Mutation News and Research

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Researchers use magic-angle-spinning NMR to unveil structure of CAP-Gly protein

A latticework of tiny tubes called microtubules gives your cells their shape and also acts like a railroad track that essential proteins travel on. But if there is a glitch in the connection between train and track, diseases can occur.

26 Nov 2015

Novel anticancer agent appears to have greater potency, longer efficacy than irinotecan and topotecan

In the five decades since camptothecin was first isolated from the bark of a tree used in traditional Chinese medicine and identified as a powerful anticancer agent, several thousand chemicals with similar structures and functions have been investigated. And while two of these analog compounds, irinotecan and topotecan, have been approved in the U.S. as treatments for cancer, both are associated with significant shortcomings.

26 Nov 2015

Exploring how absence of ASS1 protein affects sick children may provide a 'lens' on cancer

What can a rare genetic childhood disease teach us about cancer? Dr. Ayelet Erez of the Weizmann Institute of Science's Department of Biological Regulation says: "A single-mutation disease can act as a 'lens.' If we find exactly what malfunctions in the sick child, we can zoom in and understand the role of the same gene among the many genetic changes that accompany cancer."

26 Nov 2015

Research reveals MECP2 Duplication Syndrome can be reversed

The methyl CpG binding protein 2 gene (MECP2) produces a protein of the same name, the level of which is critical for normal brain function. Mutations leading to protein under-expression cause Rett Syndrome while gene duplication causing over-expression lead to MECP2 Duplication Syndrome. Both disorders are severely debilitating childhood neurological diseases.

26 Nov 2015

Study points to new avenue for developing potential strategies to thwart HIV virus

Nearly 37 million people worldwide are living with HIV. When the virus destroys so many immune cells that the body can't fight off infection, AIDS will develop. The disease took the lives of more than a million people last year.

26 Nov 2015

Scientists map out genes that keep cancer cells alive

Scientists have mapped out the genes that keep our cells alive, creating a long-awaited foothold for understanding how our genome works and which genes are crucial in disease like cancer.

26 Nov 2015

New drug may show promise against resistant melanomas

A new drug discovered by scientists at Sanford Burnham Prebys Medical Discovery Institute may show promise for treating skin cancers that are resistant or unresponsive to today's leading therapies.

25 Nov 2015

New research could lead to improved methods of detection for early-onset Parkinson's

New research by biologists at the University of York could lead to improved methods of detection for early-onset Parkinson's Disease (PD).

25 Nov 2015

People with viral infections and identical gene mutations may be prone to hyperinflammatory disorder

A group of people with fatal H1N1 flu died after their viral infections triggered a deadly hyperinflammatory disorder in susceptible individuals with gene mutations linked to the overactive immune response, according to a study in The Journal of Infectious Diseases.

25 Nov 2015

RPCI-led researchers identify strategies to prevent acute kidney injury

Acute kidney injury (AKI), also known as acute renal failure, is one of the main contributors to death and disability worldwide, yet no preventive treatment for the condition has been established. In a new study published in the journal Cell Death and Differentiation, a team of researchers led by scientists from Roswell Park Cancer Institute reports that they have identified 10 genes whose inhibition appears to protect kidney cells.

25 Nov 2015

Slower aging reduces degeneration related to Parkinson's disease

Humans have long sought to reduce the effects of aging. Now, there may be another reason to continue searching for ways to slow the clock--preventing Parkinson's disease.

25 Nov 2015

Researchers reveal causal association between aneuploidy and cancer

Publication in Nature Cell Biology: researchers at the Université libre de Bruxelles - ULB Cancer Research Center, U-CRC - show the causal link between aneuploidy and cancer.

24 Nov 2015

Finding may lead to better understanding of male genital birth defects

University of Florida Health researchers have identified genes that are disrupted by abnormal hormone signaling at crucial points during development, a finding that may lead to a better understanding of how the most common male genital birth defects arise in humans.

24 Nov 2015

Addition of sugar molecules to particular proteins vital for plants in basic developmental processes

Adding a spoonful of sugar to coffee makes it sweeter, but in plants, researchers have discovered, the addition of sugar molecules to particular proteins plays a surprising variety of roles in basic developmental processes.

23 Nov 2015

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

Research from investigators at Rutgers Cancer Institute of New Jersey examining the inner workings of a rare non-cancerous (benign) kidney tumor has revealed a mechanism to prevent this type of tumor from becoming cancerous (malignant).

22 Nov 2015

U of T researchers discover mysterious fungus that defends against neighbouring bacteria

Researchers at the University of Toronto examined fungi in the mucus of patients with cystic fibrosis and discovered how one particularly cunning fungal species has evolved to defend itself against neighbouring bacteria.

21 Nov 2015

Crucial tumor-suppressing gene protects immune attack against lung cancer

A crucial tumor-thwarting gene protects an immune attack against lung cancer by blocking the key to an off switch on T cells, the customized warriors of the immune system, a team led by researchers at The University of Texas MD Anderson Cancer Center reports in the Journal of the National Cancer Institute.

21 Nov 2015

New drug screening method may predict treatment options for patients with multiple myeloma

A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer. The process, developed by scientists at Washington University School of Medicine in St. Louis, also may aid patients with leukemia or lymphoma.

21 Nov 2015

MCG researchers explore how neurofibromatosis puts young patients at risk for cardiovascular disease

It's a fairly common genetic condition that can surface as a series of dark skin spots and result in a host of maladies from tumors to premature cardiovascular disease. Medical College of Georgia researchers hope their studies of how neurofibromatosis 1, or NF1, can dangerously thicken or thin blood vessel walls will one day help physicians better identify and treat these young patients at cardiovascular risk.

20 Nov 2015

Rockefeller University researchers discover molecule that helps guide axons during CNS development

During embryonic development, billions of neurons nimbly reposition themselves within the brain and spinal cord, and connect branches to form the neural circuits that ultimately control our movements, perception, and memory. Scientists have long sought to understand the driving forces in this meticulously choreographed dance, in which each cell seems to know precisely where to be to at any given time, and with what other cells it must link.

20 Nov 2015

Mutation News and Research

Researchers use magic-angle-spinning NMR to unveil structure of CAP-Gly protein

Novel anticancer agent appears to have greater potency, longer efficacy than irinotecan and topotecan

Exploring how absence of ASS1 protein affects sick children may provide a 'lens' on cancer

Research reveals MECP2 Duplication Syndrome can be reversed

Study points to new avenue for developing potential strategies to thwart HIV virus

Scientists map out genes that keep cancer cells alive

New drug may show promise against resistant melanomas

New research could lead to improved methods of detection for early-onset Parkinson's

People with viral infections and identical gene mutations may be prone to hyperinflammatory disorder

RPCI-led researchers identify strategies to prevent acute kidney injury

Slower aging reduces degeneration related to Parkinson's disease

Researchers reveal causal association between aneuploidy and cancer

Finding may lead to better understanding of male genital birth defects

Addition of sugar molecules to particular proteins vital for plants in basic developmental processes

Rutgers research reveals mechanism to prevent benign kidney tumor from becoming cancerous

U of T researchers discover mysterious fungus that defends against neighbouring bacteria

Crucial tumor-suppressing gene protects immune attack against lung cancer

New drug screening method may predict treatment options for patients with multiple myeloma

MCG researchers explore how neurofibromatosis puts young patients at risk for cardiovascular disease

Rockefeller University researchers discover molecule that helps guide axons during CNS development

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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