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MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Pericytes are the primary locus of matrix-mellaproteinase-9-dependent (MMP-9) capillary damage and blood leakage during ischemia, according to preclinical findings reported by Medical University of South Carolina investigators in an article published online on November 14, 2016 by The Journal of Neuroscience.

5 Dec 2016

Enzyme research provides new insights into pathophysiology of depression

Despite the fact that more than four percent of the world's population suffer from depression, and even though approximately 1,500 individuals commit suicide each year in Sweden, the understanding of the pathophysiology of depression remains unclear and only a few new discoveries of mechanisms behind it have been made in recent years.

29 Nov 2016

Scientists uncover novel process by which APOL1 gene contributes to renal disease

A Children's National Health System research team has uncovered a novel process by which the gene APOL1 contributes to renal disease, according to a paper published November 18 in the Journal of the American Society of Nephrology.

18 Nov 2016

Research sheds new light on potential of anti-inflammatory cytokines in treating aging-related metabolic diseases

New research published online in The FASEB Journal suggests that the anti-inflammatory molecule IL-10 may do more than just reduce inflammation.

16 Nov 2016

Researchers identify potential new treatment for brain cancer by targeting genes linked to microcephaly

University of North Carolina Lineberger Comprehensive Cancer Center researchers have identified a potential new treatment for brain cancer by learning from a rare condition that can cause microcephaly.

1 Nov 2016

Allen Institute for Brain Science maps the mouse cortex in 3-D

The Allen Institute for Brain Science has completed the three-dimensional mapping of the mouse cortex as part of the Allen Mouse Common Coordinate Framework (CCF): a standardized spatial coordinate system for comparing many types of data on the brain from the suite of Allen Brain Atlas resources.

27 Oct 2016

Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows

New research published online in The FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-β peptides, a primary culprit in Alzheimer's disease.

26 Oct 2016

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.

25 Oct 2016

URMC scientists receive award to explore new treatments for Huntington's disease

A new award from the CHDI Foundation will advance promising research that aims to slow the progression of Huntington's disease.

13 Oct 2016

Measuring the activity of a mouse brain from a single snapshot

Drs Nicolas Renier and Zhuhao Wu are post-doctoral fellows in the laboratory of Marc Tessier-Lavigne, Carson Family Professor and head of the Laboratory of Brain Development and Repair and President of Rockefeller University in New York. Over recent years, they have co-developed methodologies for new imaging techniques applying light sheet microscopy. Their latest work shows the study of neuronal activity in intact brains.

12 Oct 2016

Japanese researchers discover causative gene for common type of hearing loss

A causative gene for a highly common type of hearing loss (sensorineural hearing loss, or SNHL) has been identified by a group of Japanese researchers, who successfully replicated the condition using a transgenic mouse.

6 Oct 2016

CBN neuroscientists awarded NIMH grant to develop novel genome engineering research tools

The Center for Behavioral Neuroscience at Georgia State University has received a two-year, exploratory grant from the National Institute of Mental Health to develop transformative genome engineering research tools.

20 Sep 2016

Experimental co-culture approach facilitates study of cellular events underlying Huntington's disease

Using an experimental co-culture approach in which two different types of neurons from a mouse model of Huntington's disease (HD) are grown side-by-side, connecting to form critically impacted circuits, researchers at University of California San Diego School of Medicine have identified a subunit of a protein that, when expressed, reverse the mutated gene effects responsible for HD.

6 Sep 2016

Common signaling pathway may control formation of tumor cells in fat, reveals Purdue study

A common cell signaling pathway that controls differentiation of stem cells may also control the formation of tumor cells in fat, according to a Purdue University study.

31 Aug 2016

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

The tidal wave approaches. In the coming decades, Alzheimer's disease is projected to exact a devastating economic and emotional toll on society, with patient numbers in the US alone expected to reach 13.5 million by mid-century at a projected cost of over a trillion dollars.

30 Aug 2016

Transgenic News and Research

MUSC researchers harness cutting-edge technology to uncover new role for pericytes during stroke

Enzyme research provides new insights into pathophysiology of depression

Scientists uncover novel process by which APOL1 gene contributes to renal disease

Research sheds new light on potential of anti-inflammatory cytokines in treating aging-related metabolic diseases

Researchers identify potential new treatment for brain cancer by targeting genes linked to microcephaly

Allen Institute for Brain Science maps the mouse cortex in 3-D

Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

URMC scientists receive award to explore new treatments for Huntington's disease

Measuring the activity of a mouse brain from a single snapshot

Japanese researchers discover causative gene for common type of hearing loss

CBN neuroscientists awarded NIMH grant to develop novel genome engineering research tools

Experimental co-culture approach facilitates study of cellular events underlying Huntington's disease

Common signaling pathway may control formation of tumor cells in fat, reveals Purdue study

Multi-purpose protein may offer clues for successful treatment of Alzheimer's disease

Study suggests structural changes in the brain help cope with stressful situations

Commonly used anti-inflammatory drug shows potential to treat Alzheimer's disease

UW Medicine researchers discover new type of neuron in mouse retina

Novel therapeutic strategy could target multiple aspects of Alzheimer's disease

Loss of senescent cells improves pulmonary function in mice

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