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Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Findings from a new Cleveland Clinic-led phase 1 trial show that an experimental "gene silencing" therapy reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 98%.

3 Apr 2022

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Scientists at Northwestern Medicine are using new advances in CRISPR gene-editing technology to uncover new biology that could lead to longer-lasting treatments and new therapeutic strategies for Human Immunodeficiency Virus (HIV).

1 Apr 2022

Research illuminates why immune disorders affect only one of two identical twins

Scientists have long queried the causes of immune disorders in only one of two identical twins with identical genes. New research from the Wellcome Sanger Institute, the Josep Carreras Leukaemia Research Institute in Spain and their collaborators, has found the answer lies in both alterations in immune cell-cell communication and the epigenome, the host of biological processes that regulate how our genes function.

1 Apr 2022

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

Researchers developed a novel high-throughput method to obtain monoclonal antibodies from COVID-19 individuals infected with SARS-CoV-2 ancestral strain Wuhan-Hu-1 and the Beta or Gamma variants.

1 Apr 2022

UW Medicine scientists contribute to the publication of first complete, gapless genome sequence

UW Medicine genome scientists were among the leading contributors to the publication of the first complete, gapless sequence of a human genome announced this week by the National Human Genome Research Institute.

31 Mar 2022

$2.05 million to support UTHSC's advanced genetics project on breast cancer

A University of Tennessee Health Science Center team has received $2.05 million from the National Cancer Institute for an advanced genetics project that could help develop targeted therapies and personalized treatment for breast cancer. Liza Makowski, PhD, professor of Hematology and Oncology in the College of Medicine, is the lead investigator on the award.

31 Mar 2022

Novaplex real-time PCR assays can reliably, rapidly detect SARS-CoV-2 in patient samples

A new study has found that the Novaplex SARS-CoV-2 Variant I, II, and IV real-time PCR assays (from Seegene Technology) can reliably detect SARS-CoV-2 in patient samples and identify known variants of interest and concern.

31 Mar 2022

Yale researchers identify accelerated genetic aging in breast tissue adjacent to tumors

An analysis by Yale Cancer Center researchers identified accelerated genetic aging in breast tissue adjacent to breast cancer tumors.

31 Mar 2022

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Most of us remember enough biology to recall that mitochondria are known as "the powerhouse of the cell." Even that audacious term may downplay the importance of mitochondria and what happens when mitochondria go bad.

31 Mar 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Researchers examined the unique clusters of monocytes and regulatory T cells in the circulating blood from convalescent COVID-19 patients over a prolonged period after recovery, using scRNA sequencing.

31 Mar 2022

Study identifies a set of sporadic genetic mutations behind cavernous angioma

A rare type of brain blood vessel malformation known as a cavernous angioma affects more than one million Americans and carries a lifetime risk of stroke and seizures.

30 Mar 2022

Decisive role of PDK1 enzyme in acute myeloid leukemia revealed

Acute myeloid leukemia (AML) remains harder to treat therapeutically due to the high existing genetic heterogeneity not only between patients but also between the population of subclones of cancer cells within the same person.

30 Mar 2022

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

While cancer therapies targeting specific genes or disease pathways have extended lives, they can also lead to highly resistant tumors when small reservoirs of cancer cells survive treatment, grow, and spread.

30 Mar 2022

Researchers discover potential link between inflammation and structure of specific brain regions

A potential link between inflammation and the structure of specific regions of the brain has been identified by researchers at the University of Birmingham.

30 Mar 2022

Study identifies 10 new genetic regions linked with Brugada syndrome

A recent study published in Nature Genetics identified 10 new genetic regions associated with Brugada syndrome, a cardiac arrhythmia disorder associated with sudden death in young adults.

30 Mar 2022

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Researchers proposed an optimal system to generate SARS-CoV-2 virus-like particles for examining viral assembly and entry into target host cells.

30 Mar 2022

Discovering a new possible treatment for COVID-19

In this interview, we speak to Dr. Ahmed G. Ibrahim about his latest research that has discovered a new possible treatment for COVID-19.

30 Mar 2022

Antiviral functions of interferon regulatory factors during human coronavirus infection

Researchers assessed the roles of the interferon regulatory factors: IRF1, IRF3, and IRF7 in infections by human coronaviruses.

30 Mar 2022

Study describes the identification of a SARS-CoV-2 variant that escapes detection by antigen tests

Researchers raised concerns that some SARS-CoV-2 variants can escape detection by antigen tests.

30 Mar 2022

Genes News and Research

Experimental siRNA therapy reduces a key driver of heart disease risk by up to 98%

Scientists use new CRISPR gene-editing approach to find paths toward possible HIV cure

Research illuminates why immune disorders affect only one of two identical twins

Researchers explore a novel method to isolate monoclonal antibodies from COVID-19 convalescents infected with SARS-CoV-2 variants

UW Medicine scientists contribute to the publication of first complete, gapless genome sequence

$2.05 million to support UTHSC's advanced genetics project on breast cancer

Novaplex real-time PCR assays can reliably, rapidly detect SARS-CoV-2 in patient samples

Yale researchers identify accelerated genetic aging in breast tissue adjacent to tumors

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

Study determines the molecular signatures of monocytes and regulatory T cells in the circulating blood of COVID-19 patients

Study identifies a set of sporadic genetic mutations behind cavernous angioma

Decisive role of PDK1 enzyme in acute myeloid leukemia revealed

New tactic to disrupt cancer repair mechanism could lead to a potential treatment strategy

Researchers discover potential link between inflammation and structure of specific brain regions

Study identifies 10 new genetic regions linked with Brugada syndrome

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Discovering a new possible treatment for COVID-19

Antiviral functions of interferon regulatory factors during human coronavirus infection

Study describes the identification of a SARS-CoV-2 variant that escapes detection by antigen tests

eBook: Using iPSCs models for human disease research and drug discovery eBook

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