Mutation News and Research

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Findings could lead to new treatment for ALS, dementia

University of Toronto (U of T) researchers are proposing a new way of understanding Amyotrophic Lateral Sclerosis (ALS), the devastating and incurable neurological disease. Their findings, published today in the journal Neuron, could be a major milestone on the path to a treatment for both ALS and dementia.

30 Oct 2015

Women with elevated breast cancer risk can benefit from regular physical activity

Regular physical activity could play a role in helping women at high-risk of breast cancer delay the need for drastic preventive measures such as prophylactic mastectomy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania.

30 Oct 2015

Single gene variation may influence obesity in children, adults

A single variation in the gene for brain-derived neurotropic factor (BDNF) may influence obesity in children and adults, according to a new study funded by the National Institutes of Health.

30 Oct 2015

Gut bacteria may increase risk of metabolic syndrome

An excess of bacteria in the gut can change the way the liver processes fat and could lead to the development of metabolic syndrome, according to health researchers.

30 Oct 2015

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

Gastric cancer, otherwise known as stomach cancer, does not respond well to existing treatments and it is currently the third leading cause of cancer death in the world (after lung and liver cancer). Researchers have discovered that certain drugs, currently used to treat breast, ovarian and pancreatic cancers, could also be used to treat certain gastric cancers with a particular pattern of mutations (genomic molecular fingerprint).

29 Oct 2015

Breastfeeding associated with lower risk of developing hormone-receptor negative breast cancer

A large international study shows that breastfeeding is associated with a lower risk of developing an aggressive form of breast cancer called hormone-receptor negative. This new combined evidence shows the risk was reduced by up to 20% in women who breastfed.

29 Oct 2015

Franziska Michor named recipient of NYSCF - Robertson Stem Cell Prize

The New York Stem Cell Foundation announced today that Franziska Michor, PhD, is the 2015 recipient of the NYSCF - Robertson Stem Cell Prize for her work pioneering new approaches to study the growth, spread, and treatment of cancer. Her laboratory fuses her passions in mathematics, molecular biology and patient care to investigate how cancers form and progress.

29 Oct 2015

Researchers identify role of cGAS enzyme in autoimmune diseases

Activating an enzyme that sounds an alarm for the body's innate immune system causes two lethal autoimmune diseases in mice, while inhibiting the same enzyme rescues them, UT Southwestern Medical Center researchers report.

28 Oct 2015

Study suggests potential new way to block cancer-causing gene

A new study suggests a potential new way to block one of the most common cancer-causing genes, without causing severe side effects.

28 Oct 2015

New method to grow 3D pancreatic cancer organoid may help test drug responses and personalized treatments

The development of a new method to grow three-dimensional organoid cultures of pancreatic tumors directly from patients' surgical tissue offers a promising opportunity for testing targeted therapies and drug responses and personalizing treatments in a rapid, cost-effective manner.

28 Oct 2015

Experts call for better risk profiling for GI cancers

Cancers of the gastrointestinal (GI) tract continue to exert their toll across Europe, with many diagnosed too late for effective treatment. Bowel cancer screening programmes are now underway in most European countries, but screening for other GI cancers is patchy and not necessarily well-targeted.

28 Oct 2015

Entry of eleven novel therapies expected to drive NSCLC market's growth to $12.7 billion in 2024

Decision Resources Group finds that the entry of eleven novel therapies into the non-small-cell lung cancer (NSCLC) market will drive the market's growth from $5.4 billion in 2014 to $12.7 billion in 2024.

27 Oct 2015

Study uncovers new genetic variants linked to increased risk of testicular cancer

A new study of more than 25,000 men has uncovered four new genetic variants associated with increased risk of testicular cancer.

27 Oct 2015

Discovery may open new doors to understanding how melanoma grows and spreads

Of the hundreds of genes that can be mutated in a single case of melanoma, only a handful may be true "drivers" of cancer. In research that recently appeared in Nature Genetics, a Weizmann Institute of Science team has now revealed one of the drivers of a particularly deadly subset of melanomas that is seeing a rise in new cases.

27 Oct 2015

Researchers develop multiplexed screening approach to study cancer development in mice

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their cancer-causing roles and determining which combinations of genes cooperate to cause liver cancer.

27 Oct 2015

New drug combination may be effective against malignant melanoma

A team of Massachusetts General Hospital investigators has discovered a new combination of drugs that may be effective against one of the deadliest cancers, malignant melanoma. The combination - pairing a drug targeted against mutations in the BRAF gene with a second drug that targets another important signaling pathway - was discovered through one of the largest screens of cancer drug combinations conducted to date.

27 Oct 2015

UW researchers develop new model to more accurately predict harmful genetic mutations

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA.

26 Oct 2015

Study: Blackouts, near drownings linked to sudden death risk

The annual congress of the South African Heart Association is being held in Rustenburg from Oct. 25-28, 2015. Experts from the European Society of Cardiology will present a special programme.

26 Oct 2015

Plague endemic in man since early Bronze Age, but has not always been flea-borne

A recent analysis of ancient DNA has revealed that the plaque had been endemic in humans for at least 3000 years before the first global outbreak on record (the Plague of Justinian in 541 AD). Furthermore, the disease was not always transmitted by fleas, with mutation to the bubonic form only occurring around the start of the 1st millennium BC.

23 Oct 2015

Nivolumab vs docetaxel updated results for nonsquamous, squamous NSCLC

Follow-up results from two trials of the programmed death 1 receptor inhibitor nivolumab versus docetaxel in patients with advanced non-small cell lung cancer were reported at a proffered paper session held at the European Cancer Congress in Vienna, Austria.

23 Oct 2015

Mutation News and Research

Findings could lead to new treatment for ALS, dementia

Women with elevated breast cancer risk can benefit from regular physical activity

Single gene variation may influence obesity in children, adults

Gut bacteria may increase risk of metabolic syndrome

Certain drugs could be used to treat gastric cancers with particular pattern of mutations

Breastfeeding associated with lower risk of developing hormone-receptor negative breast cancer

Franziska Michor named recipient of NYSCF - Robertson Stem Cell Prize

Researchers identify role of cGAS enzyme in autoimmune diseases

Study suggests potential new way to block cancer-causing gene

New method to grow 3D pancreatic cancer organoid may help test drug responses and personalized treatments

Experts call for better risk profiling for GI cancers

Entry of eleven novel therapies expected to drive NSCLC market's growth to $12.7 billion in 2024

Study uncovers new genetic variants linked to increased risk of testicular cancer

Discovery may open new doors to understanding how melanoma grows and spreads

Researchers develop multiplexed screening approach to study cancer development in mice

New drug combination may be effective against malignant melanoma

UW researchers develop new model to more accurately predict harmful genetic mutations

Study: Blackouts, near drownings linked to sudden death risk

Plague endemic in man since early Bronze Age, but has not always been flea-borne

Nivolumab vs docetaxel updated results for nonsquamous, squamous NSCLC

Industry Focus eBook - Cell biology (5th edition) eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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