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Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Equipping cancer-infecting, or oncolytic, viruses with tumor-inhibiting genetic cargo stimulates the immune system and helps immunotherapy to shrink or completely clear aggressive tumors in mice, according to a new study in the Journal of Experimental Medicine led by University of Pittsburgh and UPMC researchers.

14 Aug 2023

Pairing top-down and bottom-up approaches to gain insights into the origin of life

Despite decades of progress, the origin of life remains one of the great unsolved problems in science.

14 Aug 2023

Stem cells used to create organoids that secrete dental enamel proteins

Organoids have now been created from stem cells to secrete the proteins that form dental enamel, the substance that protects teeth from damage and decay.

14 Aug 2023

Study yields new knowledge about genes responsible for IgG production and release

A collaboration led by UCLA and the Seattle Children's Research Institute has yielded new knowledge about the genes responsible for the production and release of immunoglobulin G, the most common type of antibody in the human body.

14 Aug 2023

Kidney cancer study reveals new findings about MiTF family gene mutations

A new study from clinicians and researchers at the University of Michigan Rogel Cancer Center, U-M Department of Pathology and the Michigan Center for Translational Pathology reveals findings from over 800 clinical assays performed for kidney patients with MiTF family gene mutations.

14 Aug 2023

New diagnostic tool could revolutionize early bladder cancer detection

Bladder cancer has a five-year survival rate of over 80% when detected early, but this rate declines significantly as the disease progresses to advanced stages.

14 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

How does particulate matter air pollution contribute to antibiotic resistance?

Researchers explore the role of particulate matter within the environment to facilitate the spread of genetic elements responsible for antibiotic resistance.

14 Aug 2023

New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns

Researchers explore the prevalence of rare genetic forms of obesity in a United Kingdom-based clinical obesity cohort.

14 Aug 2023

Exploring DNA methylation biomarkers of multiple sclerosis

Researchers identify cell-specific DNA methylation signatures associated with MS.

14 Aug 2023

Significant association found between the rs1205 T-Dom genotype and risk of COVID-19 death or hospitalization among American Indians

Researchers identify an association between the C-reactive protein gene variant rs1205 and COVID-19 severity.

14 Aug 2023

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Researchers explored the structural basis of agonist specificity of α1A-adrenergic receptors (α1-ARs).

14 Aug 2023

New gene therapy shows promise for treating fusion-driven cancers

A new study presents a promising treatment method for so-called fusion-driven cancers, which are currently often difficult to cure. These fusion-driven cancers are caused by an error in cell division that creates a fusion of different genes.

11 Aug 2023

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection.

11 Aug 2023

Study identifies 135 genes associated with human skin color

The skin, hair and eye color of more than eight billion humans is determined by the light-absorbing pigment known as melanin.

11 Aug 2023

New Alzheimer’s drug raises hopes — along with questions

The FDA has approved Leqembi, the first disease-modifying treatment for early-stage Alzheimer's and a precursor condition, mild cognitive impairment.

11 Aug 2023

Study reveals APOE-ε4 allele increases the risk for Alzheimer's and cardiovascular disease

Previous research has revealed that the Apolipoprotein-ε4 (APOE-ε4) allele increases the risk for a variety of diseases in aging populations, specifically Alzheimer's and cardiovascular disease. And yet, despite the negative effects of this genetic variant, it remains prevalent in approximately 20% of the human population.

11 Aug 2023

Machine learning can accurately predict subtypes of Parkinson's disease

Researchers at the Francis Crick Institute and UCL Queen Square Institute of Neurology, working with technology company Faculty AI, have shown that machine learning can accurately predict subtypes of Parkinson's disease using images of patient-derived stem cells.

10 Aug 2023

New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy.

10 Aug 2023

Scientists develop "universal pan-mammalian clock" to accurately estimate age in mammals

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

10 Aug 2023

Genetic News and Research

Oncolytic viruses could be used to 'warm up' cold tumors and improve immunotherapy

Pairing top-down and bottom-up approaches to gain insights into the origin of life

Stem cells used to create organoids that secrete dental enamel proteins

Study yields new knowledge about genes responsible for IgG production and release

Kidney cancer study reveals new findings about MiTF family gene mutations

New diagnostic tool could revolutionize early bladder cancer detection

The role of self-extracellular nucleic acids in neuroinflammation

How does particulate matter air pollution contribute to antibiotic resistance?

New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns

Exploring DNA methylation biomarkers of multiple sclerosis

Significant association found between the rs1205 T-Dom genotype and risk of COVID-19 death or hospitalization among American Indians

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

New gene therapy shows promise for treating fusion-driven cancers

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

Study identifies 135 genes associated with human skin color

New Alzheimer’s drug raises hopes — along with questions

Study reveals APOE-ε4 allele increases the risk for Alzheimer's and cardiovascular disease

Machine learning can accurately predict subtypes of Parkinson's disease

New gene-editing tool helps to study single-base mutations in cancer

Scientists develop "universal pan-mammalian clock" to accurately estimate age in mammals

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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