B Cell News and Research

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Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins - and ultimately affect aging.

4 Jan 2024

Study identifies mitochondrial dysfunction as cause of long-COVID fatigue

Researchers from Amsterdam UMC and Vrije Universiteit Amsterdam (VU) have discovered that the persistent fatigue in patients with long-COVID has a biological cause, namely mitochondria in muscle cells that produce less energy than in healthy patients.

4 Jan 2024

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse.

4 Jan 2024

Gut microbiome plays a role in immune response to mRNA COVID vaccines

Researchers from Karolinska Institutet in Sweden have discovered that the gut microbiome can influence how well people respond to mRNA COVID vaccines.

4 Jan 2024

Study finds previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease

Researchers explored the effects of a small humanin-like peptide 2 (SHLP2) variant on mitochondrial function.

4 Jan 2024

Diet-related inflammation may raise stroke risk, US study finds

The relationship between the dietary inflammatory index (DII) and stroke incidence.

4 Jan 2024

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

Recent studies by Zampaloni et al. and Pahil et al. published in the journal Nature describe a novel method of inhibiting the growth of Gram-negative bacteria such as Acinetobacter using antibiotics consisting of macrocyclic peptides that target the bacterial protein bridge machinery that transports lipopolysaccharides from the cytoplasm to the outer membrane.

4 Jan 2024

How cancer stem cell exosomes fuel tumor growth and evade immune attack

A new editorial paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, "Therapeutically harnessing cancer stem cell-derived exosomes."

3 Jan 2024

New approach leverages macrophages to treat traumatic brain injury

Scientists have created a new treatment for traumatic brain injury (TBI) that shrank brain lesions by 56% and significantly reduced local inflammation levels in pigs.

3 Jan 2024

Radon exposure linked to increased risk of blood cell mutation in female stroke patients

Radon, a naturally occurring radioactive gas produced when metals like uranium or radium break down in rocks and soil, is a known cause of lung cancer.

3 Jan 2024

Simple technique boosts antibody delivery for treating brain diseases

The blood-brain barrier blocks the entry of antibodies into the brain. This limits the potential use of antibody therapeutics to treat brain diseases, such as brain tumors.

3 Jan 2024

EZH2 inhibitors show promise in regenerating insulin-producing cells for type 1 diabetes treatment

Study explores the potential of EZH2 inhibitors GSK126 and Tazemetostat in stimulating β-cell regeneration from pancreatic ductal progenitor cells, offering a novel therapeutic approach for Type 1 Diabetes.

3 Jan 2024

New method illuminates intricate interactions of the synaptonemal complex in nematodes

We have two copies of each chromosome in every cell in our bodies except in our reproductive cells. Sperm and egg cells contain a single copy of each chromosome with a unique mix of genes from our parents, an evolutionary trick to give our offspring genetic variability.

3 Jan 2024

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.

3 Jan 2024

New brain imaging technique sheds light on invisible mTBIs

Researchers have created a new brain imaging method that allows mild traumatic brain injuries (mTBIs) to be diagnosed, even when existing imaging techniques like magnetic resonance imaging (MRI) don't show any structural abnormalities.

3 Jan 2024

Study: High-fat diets impact genes in the intestines, brain, and immune system

A UC Riverside study to motivate your new year's resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk.

3 Jan 2024

Rare immune cell holds key to predicting melanoma treatment success

A type of immune cell can help predict which patients may benefit most from cancer immunotherapies, researchers from King's College London, Guy's and St Thomas' Hospital Trust, and the Francis Crick Institute have found.

3 Jan 2024

Patients with HPV-related head and neck cancers treated in community centers less likely to survive

Care for patients with human papillomavirus (HPV)-related squamous cell cancers of the oropharynx (an area in back of the throat) is shifting toward community cancer centers, but patients treated in this setting may be less likely to survive, according to new research by investigators from the Johns Hopkins Kimmel Cancer Center and its Head and Neck Cancer Center.

3 Jan 2024

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Yale researchers have identified a drug target that may alleviate joint degeneration associated with osteoarthritis, a debilitating condition that afflicts as many as 30 million people in the United States alone, which they report on Jan. 3 in the journal Nature.

3 Jan 2024

Existing beta blocker investigated as novel sickle cell therapy

A beta blocker typically used to treat heart problems, hemangioma, migraines and anxiety could be a new therapeutic for patients with sickle cell disease. Researchers led by Ankit A. Desai, MD, associate professor of medicine at the Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine, have been awarded a $3 million grant by the U.S. Department of Defense to evaluate the efficacy of this drug.

3 Jan 2024

B Cell News and Research

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Study identifies mitochondrial dysfunction as cause of long-COVID fatigue

Researchers develop peptide to target "chaotic" MYC protein in 75% of cancers

Gut microbiome plays a role in immune response to mRNA COVID vaccines

Study finds previously unidentified genetic mutation in a small protein provides significant protection against Parkinson’s disease

Diet-related inflammation may raise stroke risk, US study finds

New compound effective against bacterial species resistant to multiple classes of existing antibiotics

How cancer stem cell exosomes fuel tumor growth and evade immune attack

New approach leverages macrophages to treat traumatic brain injury

Radon exposure linked to increased risk of blood cell mutation in female stroke patients

Simple technique boosts antibody delivery for treating brain diseases

EZH2 inhibitors show promise in regenerating insulin-producing cells for type 1 diabetes treatment

New method illuminates intricate interactions of the synaptonemal complex in nematodes

Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

New brain imaging technique sheds light on invisible mTBIs

Study: High-fat diets impact genes in the intestines, brain, and immune system

Rare immune cell holds key to predicting melanoma treatment success

Patients with HPV-related head and neck cancers treated in community centers less likely to survive

Yale scientists identify drug target that may alleviate joint degeneration in osteoarthritis

Existing beta blocker investigated as novel sickle cell therapy

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