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New discovery points to potential drug targets for ASXL1-mutant chronic myelomonocytic leukemia

New research from Mayo Clinic's Center for Individualized Medicine finds that patients with ASXL1-mutant chronic myelomonocytic leukemia - an uncommon type of cancer of the bone marrow - have distinctive epigenetic changes that can activate harmful genes and cause the cancer to grow faster.

18 Mar 2022

New 'Shared Commitments' set out priority actions across the UK to improve healthcare through genomics

The UK government, Welsh and Scottish Governments and Northern Ireland Assembly have today (Friday 18 march) agreed a series of commitments to improve outcomes for patients through better genomic testing and access to clinical trials.

18 Mar 2022

Research demonstrates within-host seasonal immunity

Researchers investigate the association between seasonal flu changes and gene expression to determine the ‘within-host’ immunity concept.

17 Mar 2022

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether.

17 Mar 2022

Researchers identify a gene that could prevent Parkinson’s disease

Parkinson's disease is a neurodegenerative disorder characterized by the destruction of a specific population of neurons: the dopaminergic neurons.

17 Mar 2022

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Researchers reported the association of a single nucleotide polymorphism rs9984273 in the interferon-alpha/beta receptor gene with outcomes of acute respiratory distress syndrome and COVID-19.

17 Mar 2022

Transcription factors work together to drive cancer cell proliferation

Scientists have discovered that a well-established cancer cell transcription factor and its newly identified co-factor work together to drive cancer cell proliferation, according to findings published in Science Advances.

16 Mar 2022

Novel oncogenic gene fusions identified in lung and pancreatic cancer

A Yale Cancer Center research team has identified novel oncogenic gene fusions in lung and pancreatic cancer, as well as sarcoma.

16 Mar 2022

New insight into how gut bacteria work to counter intestinal inflammation

Bile acids made by the liver have long been known for their critical role in helping to absorb the food we ingest.

16 Mar 2022

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Researchers determined the immune signature of the multisystem inflammatory syndrome in children among hospitalized children diagnosed with SARS‐CoV‐2 infection.

16 Mar 2022

Epigenetic changes could be a biomarker for early detection of type 1 diabetes

Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system already before the antibodies of the disease are detected in their blood.

16 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

Researchers evaluate the feasibility of tonsil epithelial cell-derived organoids as an ex vivo model for studying SARS-CoV-2 infection.

15 Mar 2022

High blood pressure genes improve outcomes after congenital heart defect repair surgery

Children with a genetic makeup that predicts high blood pressure as adults are more likely to survive congenital heart defect repair surgery, according to a new study published in Circulation Research.

15 Mar 2022

Synthetic viral vector and surgical approach enable efficient gene transfer into the inner ear of primates

A synthetic viral vector and a novel surgical approach developed at Mass Eye and Ear has enabled efficient gene transfer into the inner ear of nonhuman primates, a research team working towards the development of effective treatments for hearing loss and vestibular disorders has reported.

15 Mar 2022

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

The coming of spring harkens spring cleaning; a time to de-clutter your home and discard things that are no longer needed. In the body, a cellular process called autophagy occurs regularly to "de-clutter" our cells.

15 Mar 2022

Study takes a new approach to looking at de novo genetic variants in autism

About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018 Centers for Disease Control and Prevention surveillance. How a child's DNA contributes to the development of ASD has been more of a mystery.

15 Mar 2022

Research findings may explain marked racial disparity in deaths from triple negative breast cancer

Different activity in two molecular networks could help explain why triple negative breast cancers tend to be more aggressive in African American (AA) women compared with white American (WA) women, a new study led by Johns Hopkins Kimmel Cancer Center researchers suggests.

15 Mar 2022

Study shows genetic link between endometriosis and ovarian cancer subtypes

University of Queensland researchers have demonstrated a genetic link between endometriosis and ovarian cancer subtypes enabling them to identify potential drug targets for therapy and increasing the understanding of both diseases.

15 Mar 2022

Study finds elevated inflammation in macrophages months after mild COVID-19

There is a lack of understanding as to why some people suffer from long-lasting symptoms after COVID-19 infection.

15 Mar 2022

Genes News and Research

New discovery points to potential drug targets for ASXL1-mutant chronic myelomonocytic leukemia

New 'Shared Commitments' set out priority actions across the UK to improve healthcare through genomics

Research demonstrates within-host seasonal immunity

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Researchers identify a gene that could prevent Parkinson’s disease

Study suggests single nucleotide polymorphism in interferon receptor impacts COVID-19 outcomes

Transcription factors work together to drive cancer cell proliferation

Novel oncogenic gene fusions identified in lung and pancreatic cancer

New insight into how gut bacteria work to counter intestinal inflammation

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Epigenetic changes could be a biomarker for early detection of type 1 diabetes

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

SARS-CoV-2 infection model generated from human tonsil epithelial organoids

High blood pressure genes improve outcomes after congenital heart defect repair surgery

Synthetic viral vector and surgical approach enable efficient gene transfer into the inner ear of primates

Researchers illuminate the link between autophagy and the body's metabolic response to fasting

Study takes a new approach to looking at de novo genetic variants in autism

Research findings may explain marked racial disparity in deaths from triple negative breast cancer

Study shows genetic link between endometriosis and ovarian cancer subtypes

Study finds elevated inflammation in macrophages months after mild COVID-19

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