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Drug in clinical trials for Parkinson's disease offers hope for treating heart failure

A drug currently in clinical trials for treating symptoms of Parkinson's disease may someday have value for treating heart failure, according to results of early animal studies by Johns Hopkins Medicine researchers.

20 Jul 2018

Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer's

Ultrasound waves applied to the whole brain improve cognitive dysfunction in mice with conditions simulating vascular dementia and Alzheimer's disease.

20 Jul 2018

Gene therapy may hold potential to treat people with spinal cord injuries

Delivering a single injection of a scar-busting gene to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.

20 Jul 2018

Researchers identify enzyme as potential new drug target for blood disorders

Medical researchers have identified a key signaling protein that regulates hemoglobin production in red blood cells, offering a possible target for a future innovative drug to treat sickle cell disease.

20 Jul 2018

Scientists identify hidden signals in RNAs that control protein synthesis

Scientists have long known that RNA encodes instructions to make proteins. The building blocks that comprise RNA - A, U, C, and Gs - form a blueprint for the protein-making machinery in cells. To make proteins, the machinery latches on RNA at one end and then scans along the RNA until it reaches an AUG string, which is the signal to start translating the genetic code into a protein.

17 Jul 2018

Study delves into the role played by Protein Kinase C in synaptic plasticity

Inside the brain, is a complex symphony of perfectly coordinated signaling. Hundreds of different molecules amplify, modify and carry information from tiny synaptic compartments all the way through the entire length of a neuron.

17 Jul 2018

Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease

A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore.

16 Jul 2018

Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite

In an article published recently in the journal Nature Communications, researchers affiliated with the University of São Paulo in Brazil describe the central role played by an enzyme called phosphatidylinositol 3-kinase gamma in regulating the immune response against Trypanosoma cruzi, the protozoan parasite that causes Chagas disease.

16 Jul 2018

New drug strategy can alleviate multiple behavioral, cellular deficiencies in FXS mouse model

Research in mice shows that a pharmacological strategy can alleviate multiple behavioral and cellular deficiencies in a mouse model of fragile X syndrome, the most common inherited form of intellectual disability and a major single-gene cause of autism spectrum disorders.

13 Jul 2018

Scientists identify structural and functional differences in human immune-surveillance protein

The human body is built for survival. Each one of its cells is closely guarded by a set of immune proteins armed with nearly foolproof radars that detect foreign or damaged DNA.

13 Jul 2018

Research reveals why risks of complications in pregnancy vary based on baby's sex

The sex of a baby controls the level of small molecules known as metabolites in the pregnant mother's blood, which may explain why risks of some diseases in pregnancy vary depending whether the mother is carrying a boy or a girl, according to new research from the University of Cambridge.

12 Jul 2018

UZH scientists identify enzyme that controls cell division

When a cell divides, its constituents are usually evenly distributed among the daughter cells. UZH researchers have now identified an enzyme that guarantees that cell constituents that are concentrated in organelles without a membrane are properly distributed.

12 Jul 2018

Captozyme begins cross-over study of Nephure oxalate reducing enzyme

Captozyme, Inc. announced today that it is initiating a prospective double-blind, randomized, placebo controlled, cross-over study, with Nephure, an oxalate reducing enzyme, to determine the extent to which Nephure vs. placebo reduces urinary oxalate excretion (mg/24 hour) in healthy subjects who are provided a controlled diet.

12 Jul 2018