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Study sheds new light on how anti-cancer agent inhibits tumor growth

Researchers at Sanford Burnham Prebys Medical Discovery Institute have published a study in Nature Communications shedding new light on how K-80003 (TX803), an anti-cancer agent discovered at the Institute, prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth.

4 Aug 2017

Modifying gene expression may provide path to preventive treatments for heart failure, study suggests

Heart failure refers to a condition in which heart muscle becomes weakened over time, making it increasingly difficult for the heart to pump blood through the body like it should.

4 Aug 2017

Kinase-inactive BRAF mutation triggers lung adenocarcinoma development

The initiating oncogenic event in almost half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies.

2 Aug 2017

Mathematical modeling can guide design and distribution of genetically modified genes

So, you've genetically engineered a malaria-resistant mosquito, now what? How many mosquitos would you need to replace the disease-carrying wild type? What is the most effective distribution pattern? How could you stop a premature release of the engineered mosquitos?

1 Aug 2017

Penn researchers discover how DNA damage turns immune cells against cancer

Cancer is essentially a disease of the cell replication cycle. The goal of treating the disease is to permanently kill off the cells that replicate with abandon without any molecular brakes.

31 Jul 2017

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Sixty-four years ago, James Watson and Francis Crick described the now-iconic double helix structure of DNA.

29 Jul 2017

Hunger-controlling brain cells offer potential targets for new drugs to treat obesity

Is the solution to the obesity epidemic all in our heads? A study by researchers at The Rockefeller University suggests that it might be.

28 Jul 2017

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

How can six and half feet of DNA be folded into the tiny nucleus of a cell? Researchers funded by the National Institutes of Health have developed a new imaging method that visualizes a very different DNA structure, featuring small folds of DNA in close proximity.

27 Jul 2017

Study provides fresh insights into how the body detects early signs of cancer

Fresh insights into how cells detect damage to their DNA - a hallmark of cancer - could help explain how the body keeps disease in check.

26 Jul 2017

Low-dose anxiolytics can ameliorate social disadvantage related to trait anxiety

Psychologists speak of anxiety in two forms: "state" anxiety, which refers to anxiety arising from a particular situation; and "trait" anxiety, which refers to anxiety as part of a person's overall personality.

18 Jul 2017

Study provides insights into intergenerational inheritance of epigenetic information

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off.

18 Jul 2017

Scientists uncover new gene therapy treatment routes for motor neurone disease

Scientists investigating the genetic causes and altered functioning of nerve cells in motor neurone disease (MND) have discovered a new mechanism that could lead to fresh treatment approaches for one of the most common forms of the disease.

14 Jul 2017

EPFL researchers identify social rank as determining factor for vulnerability to stress

Stress is a major risk factor for a range of psychopathologies. However, stress does not affect everyone equally: in the face of sustained adversity, some people develop depression symptoms while others adapt and remain resilient.

13 Jul 2017

UIC researchers identify enzyme that triggers corneal inflammation

One of the symptoms of herpes simplex virus-1 infection of the eye is lingering inflammation of the cornea – the clear outer layer of the eyeball.

11 Jul 2017

Researchers get closer to finding out how cells and their nucleus grow at constant ratio

Over a century since scientists first observed that cells and their nucleus grow at a constant ratio to each other, we are now closer to finding out how.

11 Jul 2017

Synthetic compound that reads mitochondrial DNA could lead to treatments for nerve, muscle diseases

For the first time, a synthetic compound has been made that can bind to DNA in the cells' energy powerhouses, suppressing a gene associated with nerve and muscle disease.

11 Jul 2017

IBS scientists control memory by modulating synchronized brain waves during deep sleep

Have you ever tried to recall something just before going to sleep and then wake up with the memory fresh in your mind? While we absorb so much information during the day consciously or unconsciously, it is during shut eye that a lot of facts are dispatched to be filed away or fall into oblivion.

6 Jul 2017

Cell Nucleus News and Research

Study sheds new light on how anti-cancer agent inhibits tumor growth

Modifying gene expression may provide path to preventive treatments for heart failure, study suggests

Kinase-inactive BRAF mutation triggers lung adenocarcinoma development

Mathematical modeling can guide design and distribution of genetically modified genes

Penn researchers discover how DNA damage turns immune cells against cancer

New imaging approach reveals dynamic and structural interactions of DNA in cell's nucleus

Hunger-controlling brain cells offer potential targets for new drugs to treat obesity

DNA-protein structure more diverse and flexible chain than previously thought, study reveals

Study provides fresh insights into how the body detects early signs of cancer

Low-dose anxiolytics can ameliorate social disadvantage related to trait anxiety

Study provides insights into intergenerational inheritance of epigenetic information

Scientists uncover new gene therapy treatment routes for motor neurone disease

EPFL researchers identify social rank as determining factor for vulnerability to stress

UIC researchers identify enzyme that triggers corneal inflammation

Researchers get closer to finding out how cells and their nucleus grow at constant ratio

Synthetic compound that reads mitochondrial DNA could lead to treatments for nerve, muscle diseases

IBS scientists control memory by modulating synchronized brain waves during deep sleep

New technique can help predict and combat potential pandemic virus

Scientists identify neurons that play crucial roles in connecting emotions and sleep

UA researcher’s findings on estrogen may lead to promising treatment for hot flashes

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