Signaling Pathway News and Research

RSS

Scientists identify a way to reverse drug resistance by rewiring the inner workings of leukemia cells

Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells.

19 Apr 2022

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Northwestern Medicine investigators have discovered a novel signaling pathway activated by interferons, a group of immune system proteins, that suppresses the anti-tumor response of interferons in patients with a particular type of blood cancer, according to findings published in Nature Communications.

19 Apr 2022

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Inhibiting an important signaling pathway in brain-resident immune cells may calm brain inflammation and thereby slow the disease process in Alzheimer's and some other neurodegenerative diseases, suggests a study by Weill Cornell Medicine investigators.

14 Apr 2022

Maternal exercise during pregnancy improves metabolic health of offspring, shows study

A new study has demonstrated that maternal exercise during pregnancy improves the metabolic health of offspring, even when the mother is obese or on a high-fat diet.

14 Apr 2022

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

In a recent study, researchers assessed the anti-COVID-19 efficacy of Salvia miltiorrhiza Bunge.

14 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Results from early-stage clinical trials show two drugs that target the DNA damage response (DDR) pathway in cancers - ATR inhibitor elimusertib and PARP inhibitor AZD5305 - are safe and clinically beneficial in treating patients with advanced solid tumors.

11 Apr 2022

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Intestinal epithelial cells line the inner wall of the gut, creating a barrier to dangerous bacteria like enteropathogenic E. coli that seek to attach and efface that barrier, causing diarrhea.

8 Apr 2022

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

A hormone that triggers puberty and controls fertility in humans might be developed as a treatment for non-alcoholic fatty liver disease, according to new Rutgers research.

7 Apr 2022

Study says duplilumab reduces mortality from COVID-19

A recent report posted to the medRxiv* preprint server assessed the efficacy of dupilumab in blocking the IL-13 signaling pathway and its efficacy in reducing the COVID-19 associated mortality.

5 Apr 2022

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

News-Medical talks to Dr. Marlena Fejzo about a breakthrough in the understanding of hyperemesis gravidarum, and how it could improve maternal health around the world.

5 Apr 2022

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

A new study identified mechanisms regulating immune cell plasticity to develop new therapeutics.

31 Mar 2022

Increased levels of a microRNA in type 2 diabetes have negative effect on insulin secretion

Researchers at Lund University have discovered increased levels of of a microRNA in type 2 diabetes, which has a negative effect on insulin secretion.

29 Mar 2022

Potential new therapeutic target for pancreatic cancer discovered

Northwestern Medicine investigators have discovered that targeting the G alpha 13 protein in pancreatic tumors promotes tumor growth and progression, according to a study published in Cell Reports.

29 Mar 2022

New, potential treatment combination for patients with aggressive head and neck cancer

The current treatment of patients diagnosed with advanced or metastatic head and neck cancer (HNC) is ineffective.

28 Mar 2022

WVU researcher unravels role of STAT5 protein in the development of multiple sclerosis

A human immune system is a lot like the board game Mouse Trap: it's a Rube Goldberg system of interacting parts. Only instead of a falling ball causing a tiny diver to leap into a tub - which, in turn, springs a trap on some plastic mice - proteins trigger other proteins to activate immune cells and direct them toward germs.

22 Mar 2022

Signaling Pathway News and Research

Scientists identify a way to reverse drug resistance by rewiring the inner workings of leukemia cells

Researchers discover a novel signaling pathway that defines interferon responses in blood cancers

Inhibiting key signaling pathway in immune cells may slow down Alzheimer's disease

Maternal exercise during pregnancy improves metabolic health of offspring, shows study

The preclinical potential of S. miltiorrhiza extracts for the treatment of COVID-19

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Drugs targeting DNA damage response pathway show therapeutic potential against advanced solid tumors

Study defines nonredundant role for T cell-derived interleukin-22 in antibacterial defense of colonic crypts

Modified version of hormone kisspeptin can be used to treat non-alcoholic fatty liver disease

Study says duplilumab reduces mortality from COVID-19

Improving our understanding of a severe pregnancy sickness (Hyperemesis Gravidarum)

Researchers discover a cell plasticity and inflammation driving druggable copper-signaling pathway

Increased levels of a microRNA in type 2 diabetes have negative effect on insulin secretion

Potential new therapeutic target for pancreatic cancer discovered

New, potential treatment combination for patients with aggressive head and neck cancer

WVU researcher unravels role of STAT5 protein in the development of multiple sclerosis

Hypoxia-inducible factors and SARS-CoV-2 manifestations

Yale researchers uncover how to control the blood-brain barrier with a molecule

Malaria drug could help treat chemotherapy-resistant head and neck cancers

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

Latest News