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Spaceflight may be associated with accelerated aging of the immune system

As the world waits to see if Mars One can establish a human colony on Mars, scientists are working to determine the long-term consequences of living in low or no-gravity conditions, such as those that might exist on the trip to another planet. New research published online in The FASEB Journal, shows that spaceflight may be associated with a process of accelerated aging of the immune system.

4 Feb 2015

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

A University of Colorado Cancer Center study published in the journal PLoS One finds alterations in expression of genes PIK3R3 and PTEN, more commonly observed in adult tumors, in the rare, young-adult bone cancer Ewing Sarcoma, potentially offering ways to improve therapy.

4 Feb 2015

Amedica receive FDA clearance for multi-level cervical interbody cage indications

Amedica Corporation, a company that develops and commercializes silicon nitride ceramics as a biomaterial platform, announced today that the U.S. Food and Drug Administration has expanded the indications of Amedica’s silicon nitride interbody fusion products to include multi-level cervical treatment.

4 Feb 2015

Anti-viral immune cells could inhibit bone marrow transplant infections caused by CMV

Bone marrow transplantation is a life-saving therapy for patients with blood cancers like leukemia or lymphoma. However, the depletion of the patient's immune system prior to transplantation can put patients at risk of for an infection by a virus called cytomegalovirus (CMV) that can be life threatening in these immune-compromised individuals.

4 Feb 2015

Morphogenesis, University of Florida partner to develop novel device to isolate rare cells

Senior engineering students and faculty at the University of Florida in Gainesville are partnering with biotech cell and gene therapy company Morphogenesis, Inc. in Tampa to design an advanced, fully automated cell separation system capable of capturing rare cells – such as stem cells – and circulating tumor cells.

4 Feb 2015

Sleep apnea may cause some cases of osteoporosis

The daily rhythm of bone turnover is likely important for normal bone health, and recent research suggests that sleep apnea may be an unrecognized cause of some cases of osteoporosis. Sleep apnea's effects on sleep duration and quality, oxygen levels, inflammation, and other aspects of health may have a variety of impacts on bone metabolism.

3 Feb 2015

Janssen granted Priority Review from FDA for YONDELIS (trabectedin) NDA to treat STS patients

Janssen Research & Development, LLC announced today that the U.S. Food and Drug Administration has granted Priority Review for the New Drug Application (NDA) for YONDELIS (trabectedin) to treat patients with advanced soft tissue sarcoma (STS), including liposarcoma and leiomyosarcoma subtypes, who have received prior chemotherapy including an anthracycline.

3 Feb 2015

Johns Hopkins pediatricians offer guidelines on choosing between urgent care and ER

Parents have a natural tendency to fear the worst when it comes to their children and often opt for a "better safe than sorry" course of action, Canares says, but the truth is many situations don't warrant a trip to the emergency room. At the other end of the spectrum are cases that clearly require emergency attention but end up in urgent care instead — a less common scenario, Canares says.

2 Feb 2015

New research on dopamine-containing neurons could pave way for treating neurological disorders

Scientists studying hatchling fish have made a new advance in studying a chemical in the brain that impacts on movement.

2 Feb 2015

New technology preserves quality of donor tissue, allows natural joint repair option to patients

Currently, doctors have to throw away more than 80 percent of donated tissue used for joint replacements because the tissue does not survive long enough to be transplanted. Now, following a recent study, University of Missouri School of Medicine researchers have developed a new technology that more than doubles the life of the tissue.

2 Feb 2015

Upstate offers FDA-approved SMR TT metal back glenoid implant for shoulder replacements

A novel, implantable device that is less invasive and allows surgeons to perform the most challenging and complex shoulder replacements is now available at Upstate Medical University through the Upstate Bone and Joint Center.

31 Jan 2015

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers Irving L. Weissman and Joan Massagué have won this year's Charles Rodolphe Brupbacher Prize for Cancer Research: Weissman, from Stanford University, for his work on healthy and sick stem cells; Massagué, from Memorial Sloan Kettering Cancer Center in New York, for his research on metastatic spread.

31 Jan 2015

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 (SIRT1) protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

31 Jan 2015

FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

The U.S. Food and Drug Administration approval of ibrutinib (Imbruvica) to treat patients with Waldenstrom's macroglobulinemia(WM) is a significant advance for patients with this rare blood cancer.

31 Jan 2015

Pancreatic cancer cells know a way to sidestep chemotherapy, reveal Fox Chase researchers

Pancreatic cancer is one of the deadliest forms of the disease. The American Cancer Society's most recent estimates for 2014 show that over 46,000 people will be diagnosed with pancreatic cancer and more than 39,000 will die from it. Now, research led by Timothy J. Yen, PhD, Professor at Fox Chase Cancer Center, reveals that one reason this deadly form of cancer can be so challenging to treat is because its cells have found a way to sidestep chemotherapy.

30 Jan 2015

Bone News and Research

Spaceflight may be associated with accelerated aging of the immune system

Study could lead to potential therapeutic targets to treat Ewing Sarcoma

Amedica receive FDA clearance for multi-level cervical interbody cage indications

Anti-viral immune cells could inhibit bone marrow transplant infections caused by CMV

Morphogenesis, University of Florida partner to develop novel device to isolate rare cells

Sleep apnea may cause some cases of osteoporosis

Janssen granted Priority Review from FDA for YONDELIS (trabectedin) NDA to treat STS patients

Johns Hopkins pediatricians offer guidelines on choosing between urgent care and ER

New research on dopamine-containing neurons could pave way for treating neurological disorders

New technology preserves quality of donor tissue, allows natural joint repair option to patients

Upstate offers FDA-approved SMR TT metal back glenoid implant for shoulder replacements

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

FDA’s approval of ibrutinib to treat Waldenstrom's macroglobulinemia receives praises from LLS

Pancreatic cancer cells know a way to sidestep chemotherapy, reveal Fox Chase researchers

Many MEN1 tumour types found in children

Nomogram aids management of boys with constitutional delay in growth and puberty

Study helps develop better understanding of how dopamine influences behaviour

Tenofovir stems treatment-induced kidney toxicity in HBV-related chronic hepatitis

Long-term TDF therapy offers sustained HBV suppression without resistance

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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