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Stanford researchers show how to prevent immune response to gene therapy in mouse model

Stanford University School of Medicine researchers have demonstrated that gene therapy can be effective without causing a dangerous side effect common to all gene therapy: an autoimmune reaction to the normal protein, which the patient's immune system is encountering for the first time.

4 Sep 2018

Genetic mutations may drive tumor formation by blurring growth signals

Genetic mutations in a form of non-small cell lung cancer (NSCLC) may drive tumor formation by blurring cells' perception of key growth signals, according to a new laboratory study published August 31, 2018 in Science.

3 Sep 2018

A genetic signal-transmission system for the gut microbiome

More than 1,000 species of bacteria have been identified in the human gut, and understanding this incredibly diverse "microbiome" that can greatly impact health and disease is a hot topic in scientific research.

31 Aug 2018

Study provides insights into how harmful white blood cells form during tuberculosis

Insights into how harmful white blood cells form during tuberculosis infection point to novel targets for pharmacological interventions, according to a study published in the open-access journal PLOS Pathogens by Valentina Guerrini and Maria Laura Gennaro of Rutgers New Jersey Medical School, and colleagues.

31 Aug 2018

Stroke doubles the risk of dementia, shows recent large-scale study

In the largest ever study of its kind, researchers have proven the link between stroke and the development of dementia.

31 Aug 2018

Study finds that stroke significantly increases risk of dementia

People who have had a stroke are around twice as likely to develop dementia, according to the largest study of its kind ever conducted.

31 Aug 2018

New survey reveals public attitudes towards commercial use of genetic data samples

The almost 5 million people who paid to get their DNA analyzed by the company 23andMe recently found out that their genetic data and related health information might have been sold to a major drug company.

31 Aug 2018

Presence of new or worsened bedsores associated with lower quality outcomes for rehab patients

A new study from the University at Buffalo has shown that the presence of new or worsened bedsores is an effective indicator of the quality of care for rehab patients.

31 Aug 2018

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

A $2 million phase 2 Small Business Technology Transfer grant to optimize a promising new compound that has shown efficacy in preclinical studies against treatment-resistant multiple myeloma has been awarded to a Medical University of South Carolina startup company, Leukogene Therapeutics, Inc., in collaboration with MUSC researcher and company founder, Nathan G. Dolloff, Ph.D. Dolloff is an assistant professor in the Department of Cell and Molecular Pharmacology & Experimental Therapeutics at MUSC and a member of MUSC Hollings Cancer Center.

31 Aug 2018

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Commercial antidepressants typically take two to four weeks to have a significant effect on a depressed patient. They are also inneffective in approximately 40% of the cases.

31 Aug 2018

Study reveals way to regrow lost spinal cord connections

For many years, researchers have thought that the scar that forms after a spinal cord injury actively prevents damaged neurons from regrowing.

30 Aug 2018

Stigmatizing views, false perceptions about psoriasis continue to persist among people in the U.S.

The stigma associated with the autoimmune disease psoriasis may lead people to avoid patients who show signs of the condition, including not wanting to date, shake hands, or have people in their homes if they suffer from the disease.

30 Aug 2018

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that the European Commission (EC) has granted marketing authorization for ONPATTRO (patisiran) for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis in adults with stage 1 or stage 2 polyneuropathy.

30 Aug 2018

$Genome-wide association study provides insight into biologic mechanisms leading to fractures$

Genome-wide association study provides insight into biologic mechanisms leading to fractures

A paper titled "Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomization study" appeared today in the British Medical Journal.

30 Aug 2018

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Stephen Elledge, PhD, and his team did not set out to find therapies that could render tumors less resistant to therapy or make existing drugs more potent against a rare form of cancer. But these are precisely the clinical insights that their most recent study has yielded.

29 Aug 2018

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Mount Sinai researchers have discovered that a particular type of cell present in bladder cancer may be the reason why so many patients do not respond to the groundbreaking class of drugs known as PD-1 and PD-L1 immune checkpoint inhibitors, which enable the immune system to attack tumors.

29 Aug 2018

Medical School News and Research

Stanford researchers show how to prevent immune response to gene therapy in mouse model

Genetic mutations may drive tumor formation by blurring growth signals

A genetic signal-transmission system for the gut microbiome

Study provides insights into how harmful white blood cells form during tuberculosis

Stroke doubles the risk of dementia, shows recent large-scale study

Study finds that stroke significantly increases risk of dementia

New survey reveals public attitudes towards commercial use of genetic data samples

Presence of new or worsened bedsores associated with lower quality outcomes for rehab patients

Leukogene receives STTR grant to optimize compound for treatment-resistant multiple myeloma

Single dose of cannabidiol showed effective results in rats with symptoms of depression

Study reveals way to regrow lost spinal cord connections

Stigmatizing views, false perceptions about psoriasis continue to persist among people in the U.S.

EC grants marketing authorization for ONPATTRO (patisiran) in Europe

Genome-wide association study provides insight into biologic mechanisms leading to fractures

Study yields therapeutic clues to combat drug resistance in rare aggressive cancer

Researchers discover reason why many bladder cancer patients do not respond to immunotherapy

Researchers develop new approach to treating cancer using enzyme therapy

Change in type of breathing tube used for resuscitation can improve odds of survival

Cardiac arrest patients resuscitated with new breathing tube more likely to survive, finds study

Researchers find how NF2 gene mutations lead to out-of-control cellular proliferation

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

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