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Gene therapy is the best stratagem to impact the course of GM2 gangliosidosis

Since its clinical description in 1881, Tay-Sachs disease has had almost totemic significance as a cruel and relentless genetic condition that destroys the developing brain of babies and young children.

28 Apr 2018

Telomerase discovery paves way for drugs to combat aging and cancer

Researchers have published the first detailed image of the molecular structure of human telomerase, the enzyme that lengthens chromosomes and extends the lifespan of a cell.

27 Apr 2018

Scientists discover potential therapeutic target for devastating premature aging disease

Scientists from the University of Cambridge have identified a potential therapeutic target in the devastating genetic disease Hutchinson-Gilford Progeria Syndrome (HGPS), which is characterized by premature aging.

27 Apr 2018

Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

Biomedical engineers at Duke University have used a CRISPR/Cas9 genetic engineering technique to turn off a gene that regulates cholesterol levels in adult mice, leading to reduced blood cholesterol levels and gene repression lasting for six months after a single treatment.

27 Apr 2018

Neonicotinoids may impact human health by disrupting hormonal systems, shows study

Neonicotinoids are currently the most widely used pesticides in the world and frequently make headlines because of their harmful effects on honeybees and other insect pollinators

27 Apr 2018

Researchers target telomerase for killing NRAS-mutant melanoma cells

Targeting telomerase was effective at killing NRAS-mutant melanoma cells, and the impact was further enhanced when the strategy was paired with an inhibitor of mitochondrial function, according to study results by The Wistar Institute published in Oncogene.

26 Apr 2018

Drinking kefir may have positive effect on blood pressure by promoting brain-gut communication

Drinking kefir may have a positive effect on blood pressure by promoting communication between the gut and brain. Kefir is a fermented probiotic milk beverage known to help maintain the balance of beneficial bacteria in the digestive system.

26 Apr 2018

Bacteria enhance antifungal drug resistance in early childhood caries

Early childhood caries, a form of severe tooth decay affecting toddlers and preschoolers, can set children up for a lifetime of dental and health problems. The problem can be significant enough that surgery is the only effective way to treat it.

25 Apr 2018

Viruses can exploit a suprising weakness of brain cells to spark hydrocephalus

Viruses may spark hydrocephalus by exploiting a suprising weakness of cells that circulate fluid in the brain, says a new study by Duke University scientists.

25 Apr 2018

HBP researchers develop new tool to examine role of genes in disease-relevant brain regions

Elucidating the way from genes to cognition requires detailed insight into how anatomical areas with specific gene activities contribute to brain function and dysfunction. Up to now, the scientific community has developed many separate brain atlases for different modalities and scales.

25 Apr 2018

Study explains how colon cancer cells spread to the liver

Colorectal cancer is the third most common cancer worldwide and the third-leading cause of cancer-related deaths. The main cause of death in patients with colorectal cancer is liver metastasis, with nearly 70% of patients eventually developing a liver tumor.

25 Apr 2018

Researchers discover genetic catalysts that accelerate evolution of antibiotic resistance in bacteria

Researchers at Oxford University have shown that it is possible to identify genetic catalysts that accelerate the evolution of antibiotic resistance in bacteria - and that this knowledge could be used to design treatments to stifle the development of resistance.

24 Apr 2018

Contact precautions do not limit spread of drug-resistant bacteria in ICUs

Contact precautions, used in addition to the standard precautions, the basic level of infection control applied to all patients, did not limit or prevent the spread of drug-resistant bacteria in non-intensive care unit hospital wards, according to research presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases.

23 Apr 2018

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.

20 Apr 2018

Role of UBE3A enzyme in Angelman syndrome

The group, led by the Ikerbasque professor Ugo Mayor of the UPV/EHU's Department of Biochemistry and Molecular Biology, has just published in the journal Human Molecular Genetics an explanation of the mechanisms affected by Angelman syndrome.

20 Apr 2018

New CRISPR tool allows DNA editing outside of the cell

Researchers have developed a cell free method of gene editing, which uses a new version of the CRISPR tool that can edit DNA outside of the cell. This technique could revolutionize cancer care.

20 Apr 2018

AYOXXA launches advanced low-volume beads-on-a-chip multiplex protein analysis system

AYOXXA Biosystems GmbH, an international biotechnology company, today announces the introduction of its advanced low-volume beads-on-a-chip multiplex protein analysis system. The LUNARIS™ system can be readily integrated into any laboratory routine and is optimized to provide easy-to-use, standardized workflow from sample to result.

20 Apr 2018

Enzyme News and Research

Gene therapy is the best stratagem to impact the course of GM2 gangliosidosis

Telomerase discovery paves way for drugs to combat aging and cancer

Scientists discover potential therapeutic target for devastating premature aging disease

Researchers use CRISPR/Cas9 technique to turn off gene that regulates cholesterol levels in adult mice

Neonicotinoids may impact human health by disrupting hormonal systems, shows study

Researchers target telomerase for killing NRAS-mutant melanoma cells

Drinking kefir may have positive effect on blood pressure by promoting brain-gut communication

Bacteria enhance antifungal drug resistance in early childhood caries

Viruses can exploit a suprising weakness of brain cells to spark hydrocephalus

HBP researchers develop new tool to examine role of genes in disease-relevant brain regions

Study explains how colon cancer cells spread to the liver

Researchers discover genetic catalysts that accelerate evolution of antibiotic resistance in bacteria

Contact precautions do not limit spread of drug-resistant bacteria in ICUs

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Role of UBE3A enzyme in Angelman syndrome

New CRISPR tool allows DNA editing outside of the cell

AYOXXA launches advanced low-volume beads-on-a-chip multiplex protein analysis system

Interaction between dioxin and HLA gene variant activates events associated with rheumatoid arthritis

Study reports promising novel approach to treat therapy resistant pediatric brain tumors

Antioxidant treatment may decrease cardiovascular risk in women with type 1 diabetes

Measuring Drug-Target Residence Times with Biochemical Assays eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo