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New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

In a recent study published in the journal ACS Applied Bio Materials, researchers demonstrated the inhibitory potential of curcumin-encapsulated polysaccharide nanoparticles (CUR−PS-NPs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV2-SP)-stimulated cytokine storm in lung and liver epithelial cells.

8 Feb 2022

Genetically informed brain atlases help identify hundreds of genomic loci

An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.

7 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

In a study posted to the bioRxiv* preprint server, a team of researchers from Germany studied the expression data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-relevant genes such as angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and the G-protein coupled receptor Mas in an alcohol-exposed rodent model infected with SARS-CoV-2.

7 Feb 2022

Investigating the immunology of COVID-19 infected children

Researchers published a new study that focused on the key principles of developmental immunology associated with immunobiology and the clinical impacts of COVID-19 infections in children and adults.

7 Feb 2022

Study identifies 29 new genetic variants linked to acne

A study of the genetics of acne has identified 29 regions of the genome that influence the condition. These genetic insights offer potential new targets for treatment. They may also help clinicians identify individuals at high risk of severe disease.

7 Feb 2022

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

A new article reviewed the innate immune detection and signaling pathways that the host uses against SARS-CoV-2.

7 Feb 2022

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

Researchers in the United Kingdom have conducted an observational cohort study on hospitalized patients and have found that the degree of severity of acute coronavirus disease 2019 (COVID-19) predicts the occurrence of chronic cerebrovascular impairment. The study further suggests that the levels of cerebrovascular impairment are associated with worse cognitive, mental, and physical well-being.

7 Feb 2022

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

In a recent study posted to the bioRxiv* pre-print server, a team of researchers demonstrated that ubiquitin-specific peptidase 22 (USP22) is a crucial regulator of basal interferon (IFN) signaling in native human intestinal epithelial cells (hIECs).

7 Feb 2022

Sentinel cards found to be effective for indoor SARS-CoV-2 monitoring

In a recent study posted to the bioRxiv* preprint server, a team of researchers used sentinel cards for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) monitoring in schools where individual-level sampling is tedious due to privacy or compliance reasons and higher cost.

6 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Genomes of marine invertebrates found to be surprisingly stable across deep time

Scientists have discovered that the genomes of marine invertebrates have been surprisingly stable across deep time.

6 Feb 2022

Gene therapy helps heart muscle cells electrically activate in live mice

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

4 Feb 2022

Memory B cells found to potently neutralize SARS-CoV-2 Omicron variant

A team of researchers recently captured memory B cells from a cohort of SARS-CoV-2 convalescent or mRNA-vaccinated individuals to study the evolution of B cell-mediated antibody responses to the N-terminal domain in humans.

4 Feb 2022

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

In a new study, a team of researchers assessed the affinity of the SARS-CoV-2 Omicron variant of concern towards major histocompatibility complex (MHC) binding

4 Feb 2022

Scientists identify genome regions linked to migraine risk

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

3 Feb 2022

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

A genetic variant changing just one base pair of nucleotides greatly increases risk of a high-risk subtype of childhood acute lymphoblastic leukemia (ALL), according to a Northwestern Medicine study published in Nature Genetics.

3 Feb 2022

Fritz Lipmann Institute receives 2.5 million euros to advance microbiome research

Fungi, bacteria, archaea and viruses - trillions of microorganisms colonize the skin, mucous membranes and organs of humans. Together, they constitute the microbiome.

3 Feb 2022

New method may be effective at quantifying DNA adenine methylation in complex organisms

For decades, a small group of cutting-edge medical researchers have been studying a biochemical, DNA tagging system, which switches genes on or off. Many have studied it in bacteria and now some have seen signs of it in, plants, flies, and even human brain tumors.

3 Feb 2022

Genes News and Research

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

Genetically informed brain atlases help identify hundreds of genomic loci

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

Investigating the immunology of COVID-19 infected children

Study identifies 29 new genetic variants linked to acne

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

Cerebrovascular impairment persists months after severe acute COVID-19, UK study

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

Sentinel cards found to be effective for indoor SARS-CoV-2 monitoring

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Genomes of marine invertebrates found to be surprisingly stable across deep time

Gene therapy helps heart muscle cells electrically activate in live mice

Memory B cells found to potently neutralize SARS-CoV-2 Omicron variant

Predicting immunity evasion of SARS-CoV-2 Omicron variant of concern

Scientists identify genome regions linked to migraine risk

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

Fritz Lipmann Institute receives 2.5 million euros to advance microbiome research

New method may be effective at quantifying DNA adenine methylation in complex organisms

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