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UC Davis study finds higher survival rates for women diagnosed with ovarian cancer

Combing data collected on thousands of California ovarian cancer patients, UC Davis researchers have determined that almost one-third survived at least 10 years after diagnosis.

7 Aug 2015

Penn researchers identify major genetic factor that keeps moles in non-cancerous, no-growth state

Moles are benign tumors found on the skin of almost every adult. Scientists have known for years that a mutation in the BRAF gene makes them start growing, but until now haven't understood why they stop. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania have identified a major genetic factor that keeps moles in their usual non-cancerous, no-growth state.

6 Aug 2015

Genetic test may help identify better treatment option for HER2-positive breast cancer patients

A genetic test for PIK3CA mutations may help to identify patients with HER2-positive breast cancer who are less likely to benefit from combination anti-HER2 therapy, according to a study published in The Oncologist on August 5, 2015.

6 Aug 2015

Scientists use highly specialized X-ray crystallography technique to solve protein structure of HIFs

In a collaborative study between Sanford Burnham Prebys Medical Discovery Institute and the Argonne National Laboratory, scientists have used a highly specialized X-ray crystallography technique to solve the protein structure of hypoxia-inducible factors (HIFs), important regulators of a tumor's response to low oxygen (hyopoxia).

6 Aug 2015

Rice University scientists identify genetic mechanism that allows bacteria to resist antibiotics

Rice University scientists are developing strategies to keep germs from evolving resistance to antibiotics by heading them off at the pass.

5 Aug 2015

NYSCF scientists design new robotic platform to automate generation of patient-specific stem cells

Scientists at The New York Stem Cell Foundation Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells.

4 Aug 2015

Stress responder plays critical, early step in repairing DNA damage

DNA damage increases the risk of cancer, and researchers have found that a protein, known to rally when cells get stressed, plays a critical, early step in its repair.

4 Aug 2015

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

Skin cancer is the most common of all cancers, and melanoma, which accounts for 2% of skin cancer cases, is responsible for nearly all skin cancer deaths. Melanoma rates in the US have been rising rapidly over the last 30 years, and although scientists have managed to identify key risk factors, melanoma's modus operandi has eluded the world of medical research.

4 Aug 2015

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

Researchers at the Johns Hopkins University School of Medicine, Johns Hopkins University Department of Chemical and Biomolecular Engineering, and Federal University of Rio de Janeiro in Brazil have designed a DNA-loaded nanoparticle that can pass through the mucus barrier covering conducting airways of lung tissue — proving the concept, they say, that therapeutic genes may one day be delivered directly to the lungs to the levels sufficient to treat cystic fibrosis (CF), chronic obstructive pulmonary disease, asthma and other life-threatening lung diseases.

4 Aug 2015

FAU pre-medical student and surgeon work together on revolutionary procedure alternative to radical mastectomy

Elizabeth Hopkins, an aspiring physician and pre-medical student in the Charles E. Schmidt College of Science at Florida Atlantic University, has spent more than 640 hours shadowing Hilton Becker, M.D., a local plastic and reconstructive surgeon, and an affiliate professor in FAU's Charles E. Schmidt College of Medicine. Together, with Jeffrey Lind II, M.D., they authored a publication in the current issue of Plastic and Reconstructive Surgery Journal, which describes a revolutionary procedure developed by Becker that is an alternative to radical mastectomy.

4 Aug 2015

Environmental factors promote genetic mutations, have underappreciated effect on disease, evolution

Washington State University researchers say environmental factors are having an underappreciated effect on the course of disease and evolution by prompting genetic mutations through epigenetics, a process by which genes are turned on and off independent of an organism's DNA sequence.

3 Aug 2015

BRCA gene mutations and ovarian cancer: an interview with Dr Matulonis, Harvard Medical School

The BRCA gene encodes for the BRCA proteins, BRCA1 and BRCA2. These proteins are very important in repairing DNA, which they do by correcting double-stranded breaks.

2 Aug 2015

Study focuses on regulation of neuronal plasticity

A team of scientists has linked changes in the structure of a handful of central brain neurons to understanding how animals adjust to changing seasons. Its findings enhance our understanding of the mechanisms vital to the regulation of our circadian system, or internal clock.

31 Jul 2015

Researchers uncover master regulators that govern the fate of TFH cells

Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the molecular signals that drive their differentiation had remained unclear.

31 Jul 2015

Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

Roche today announced it has submitted the cobas EGFR Mutation Test v2 for Premarket Approval (PMA) to the U.S. Food and Drug Administration, as a companion diagnostic test for AZD9291, an AstraZeneca investigational therapy for non-small cell lung cancer patients with an acquired resistant mutation.

30 Jul 2015

New study reports creation of genetic porcine model of cancer

With many types of cancers, early detection offers the best hope for survival. However, research into new early-detection screenings, as well as possible interventional radiology and surgical treatments, has been hindered by the lack of a large animal model that would accurately reflect the types of cancers seen in human cells.

30 Jul 2015

Study shows how genetic changes lead to differences in form and function of species

Ten thousand years ago, a golden grain got naked, brought people together and grew to become one of the top agricultural commodities on the planet.

30 Jul 2015

Discovery could put individuals with relapsing UTIs on fast track for new therapeutic regimen

It's one thing to grow bacteria in a test tube, perform a screen in the lab, and find a mutation in the pathogen's genes. It's a whole other thing, and much rarer, to find the exact same mutation in nature--in this case, in E. coli in urine samples from some 500 patients suffering from relapsing urinary tract infections.

30 Jul 2015

Vismodegib therapy effective against medulloblastoma

A targeted therapy already used to treat advanced skin cancer is also effective against the most common subtype of the brain tumor medulloblastoma in adults and should be considered for treatment of newly diagnosed patients, according to research led by St. Jude Children's Research Hospital.

30 Jul 2015

Radiation from solar events too weak to cause birth defects down on Earth's surface

Studies find airplane crews at high altitude are exposed to potentially harmful levels of radiation from cosmic rays.

29 Jul 2015

Mutation News and Research

UC Davis study finds higher survival rates for women diagnosed with ovarian cancer

Penn researchers identify major genetic factor that keeps moles in non-cancerous, no-growth state

Genetic test may help identify better treatment option for HER2-positive breast cancer patients

Scientists use highly specialized X-ray crystallography technique to solve protein structure of HIFs

Rice University scientists identify genetic mechanism that allows bacteria to resist antibiotics

NYSCF scientists design new robotic platform to automate generation of patient-specific stem cells

Stress responder plays critical, early step in repairing DNA damage

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

First biodegradable gene delivery system efficiently penetrates human airway mucus barrier of lung tissue

FAU pre-medical student and surgeon work together on revolutionary procedure alternative to radical mastectomy

Environmental factors promote genetic mutations, have underappreciated effect on disease, evolution

BRCA gene mutations and ovarian cancer: an interview with Dr Matulonis, Harvard Medical School

Study focuses on regulation of neuronal plasticity

Researchers uncover master regulators that govern the fate of TFH cells

Roche submits cobas EGFR v2 test PMA to FDA as companion diagnostic test for AZD9291

New study reports creation of genetic porcine model of cancer

Study shows how genetic changes lead to differences in form and function of species

Discovery could put individuals with relapsing UTIs on fast track for new therapeutic regimen

Vismodegib therapy effective against medulloblastoma

Radiation from solar events too weak to cause birth defects down on Earth's surface

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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