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CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

In a new study, researchers explored the systemic immune responses during the acute and convalescent phases of SARS-CoV-2 in children and adults with the same disease severity.

3 Feb 2022

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

In a new study, researchers evaluated the neurotropism of SARS-CoV-2 and its impact on COVID-19 patients with and without neurological disorders like Alzheimer's disease.

3 Feb 2022

Study describes the first three days of SARS-CoV-2 infection in an ALI model of proximal airway epithelium

Researchers evaluated the initial three days of SARS-CoV-2 infection via scRNAseq dataset in humanized in vitro model.

3 Feb 2022

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

2 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

'Genetic scissors' can give rise to unforeseen heritable mutations

CRISPR-Cas9, the "genetic scissors", creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation.

2 Feb 2022

Researchers discover mechanism behind loss of smell in people with COVID-19

Researchers have discovered a mechanism that may explain why people with COVID-19 lose their sense of smell.

2 Feb 2022

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

In a new study, researchers assessed a rapid antigen (Ag) test for SARS-CoV-2.

2 Feb 2022

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

In a new study, researchers demonstrated that a commercial real-time polymerase chain reaction (RT-PCR) assay rapidly detects the SARS-CoV-2 Omicron variant.

2 Feb 2022

Rapid dominance of Omicron following its introduction to three Massachusetts universities

Researchers from the United States assessed the rapid dominance of the SARS-CoV-2 Omicron variant in three highly vaccinated Massachusetts university populations.

2 Feb 2022

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Your gut bacteria need vitamin B12 just as much as you do. Though DNA is usually passed from parent to child, new research shows gut bacteria transfer genes through "sex" in order to take their vitamins.

2 Feb 2022

Study finds minimal genetic difference between healthy sea stars and those with wasting syndrome

Healthy-looking ochre sea stars have minimal genetic difference from those displaying symptoms of sea star wasting syndrome, say Oregon State University researchers who examined whether genetic variation was the reason some animals went unaffected during an epidemic of the deadly disease.

2 Feb 2022

Childhood obesity more likely to be influenced by lifestyle factors than mother's BMI

Researchers from the University of Bristol and Imperial College London have found that a high Body Mass Index (BMI) of a mother before and during pregnancy is not a major cause of high BMI in their offspring – indicating that childhood and teen obesity is more likely to be a result of lifestyle factors.

1 Feb 2022

Researchers discover why patients suffering with hypertension also have diabetes

The long-standing enigma of why so many patients suffering with high blood pressure (known as hypertension) also have diabetes (high blood sugar) has finally been cracked by an international team led by the universities of Bristol, UK, and Auckland, New Zealand.

1 Feb 2022

Stigma around birth defects still plagues people in Africa

Cynthia Solomon, a 45-year-old businesswoman in Nigeria, started having issues in her matrimonial home when she gave birth to two children with Down syndrome.

1 Feb 2022

Fusion oncogenes associated with more invasive pediatric thyroid cancers, study says

Fusion oncogenes, such as RET- and NTRK-gene fusions, are associated with more invasive pediatric thyroid cancers, correlating with the highest risk of metastases and a lower likelihood of achieving remission one year after initial therapy, according to a new study by researchers at Children's Hospital of Philadelphia (CHOP).

31 Jan 2022

Dexamethasone administration at a late time point could enhance transgene expression

Dexamethasone, a glucocorticoid with anti-inflammatory and immunosuppressive effects, can transiently increase the expression of therapeutic genes delivered using adeno-associated virus (AAV) vectors.

31 Jan 2022

New study on mutation origination fundamentally challenges neo-Darwinism

A new study by a team of researchers from Israel and Ghana has brought the first evidence of nonrandom mutation in human genes, challenging a core assumption at the heart of evolutionary theory by showing a long-term directional mutational response to environmental pressure.

31 Jan 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Genes News and Research

CRISPRa method helps discover genes that play a role in immune cell biology

Innate and adaptive immune responses to SARS-CoV-2 in convalescent children and adults

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

Study describes the first three days of SARS-CoV-2 infection in an ALI model of proximal airway epithelium

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

Three different autism risk genes found to have similar effects on brain development

'Genetic scissors' can give rise to unforeseen heritable mutations

Researchers discover mechanism behind loss of smell in people with COVID-19

Rapid antigen test for SARS-CoV-2 shows lower sensitivity

N gene target failure method effectively detects SARS-CoV-2 Omicron in clinical samples

Rapid dominance of Omicron following its introduction to three Massachusetts universities

Gut bacteria transfer genes through sex to take vitamin B12, study shows

Study finds minimal genetic difference between healthy sea stars and those with wasting syndrome

Childhood obesity more likely to be influenced by lifestyle factors than mother's BMI

Researchers discover why patients suffering with hypertension also have diabetes

Stigma around birth defects still plagues people in Africa

Fusion oncogenes associated with more invasive pediatric thyroid cancers, study says

Dexamethasone administration at a late time point could enhance transgene expression

New study on mutation origination fundamentally challenges neo-Darwinism

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

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