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Chromatin regulation not governed by a uniform histone code

In a novel use of gene knockout technology, researchers at the University of California, San Diego School of Medicine tested the same gene inserted into 90 different locations in a yeast chromosome - and discovered that while the inserted gene never altered its surrounding chromatin landscape, differences in that immediate landscape measurably affected gene activity.

4 Jan 2013

Statin therapy affects muscles’ energy production

Up to 75 per cent of patients who take statins to treat elevated cholesterol levels may suffer from muscle pain. Scientists at the Center for Healthy Aging at the University of Copenhagen have now identified a possible mechanism underlying this unfortunate side effect.

4 Jan 2013

New insight into 22q11.2 deletion syndrome

Research out of the George Washington University (GW), published in the journal Proceedings of the National Academy of Sciences (PNAS), reveals another piece of the puzzle in a genetic developmental disorder that causes behavioral diseases such as autism.

4 Jan 2013

New rat model simulates traumatic or surgical muscle tissue loss in humans

Penetrating soft tissue injuries that may be caused by bullet wounds or motor vehicle accidents, or exposure to explosive devices in military settings, can cause muscle loss resulting in functional disability and cosmetic deformity. Efforts underway to develop tissue engineering solutions to repair and replace damaged and lost muscle will benefit greatly from the availability of robust animal models to test these innovative therapeutic strategies.

4 Jan 2013

Top 4 reasons why many dieters do not lose weight

The battle of the bulge is on - any movement on the scale yet? "Losing weight is one of the top resolutions made every year, yet only 20 percent of people achieve successful weight-loss and maintenance," says Jessica Bartfield,MD, internal medicine who specializes in nutrition and weight management at the Loyola Center for Metabolic Surgery & Bariatric Care.

4 Jan 2013

Scientists discover process by which mda-9/syntenin contributes to melanoma metastasis

After recently announcing success in eliminating melanoma metastasis in laboratory experiments, scientists at Virginia Commonwealth University Massey Cancer Center have made another important discovery in understanding the process by which the gene mda-9/syntenin contributes to metastasis in melanoma (the spread of skin cancer) and possibly a variety of other cancers.

4 Jan 2013

The Joint Commission, AHA/ASA recognize HUP with Comprehensive Stroke Center Certification

The Hospital of the University of Pennsylvania (HUP) has been recognized by The Joint Commission and the American Heart Association/American Stroke Association (AHA/ASA) as meeting The Joint Commission's standards for Disease-Specific Care Comprehensive Stroke Center Certification, becoming the first center in Philadelphia and among a select few hospitals in the United States to be named as part of an elite group of providers focused on complex stroke care.

4 Jan 2013

Scientists demonstrate importance of Plvap gene in mammalian physiology

Dartmouth scientists have demonstrated the importance of the gene Plvap and the structures it forms in mammalian physiology in a study published in December by the journal Developmental Cell.

4 Jan 2013

Researchers analyze impact of 3 unexpected sex determination factors

So, is it a girl or a boy? This is the first question parents ask at the birth of an infant. Though the answer is obvious, the mechanism of sex determination is much less so. Researchers at the University of Geneva (UNIGE) attempt to shed light on this complex process by identifying the crucial role played by insulin and IGF1 and IGF2 growth factors, a family of hormones known for its role in metabolism and growth.

3 Jan 2013

Longer looks: DIY abortions and the law; Helping other parents reach out to mentally ill children; Human growth hormone and Big Pharma

McCormack knew that an abortion would cost $400 to $2,000, depending on how far along she was. ... She couldn't come up with that kind of money. So she called her older sister, who owned a computer, and asked her to order abortion pills for her on the Internet.

3 Jan 2013

Comorbid Axis I disorders highly prevalent in mood disorder patients

More than 80% of patients with mood disorders have at least one comorbid Axis I disorder, study results show.

3 Jan 2013

Partin Tables to predict prostate cancer spread now updated

Prostate cancer experts at Johns Hopkins have developed an updated version of the Partin Tables, a tool to help men diagnosed with prostate cancer and their doctors to better assess their chance of a surgical cure. The updated tool, based on a study of more than 5,600 men treated at The Johns Hopkins Hospital from 2006 to 2011, is published in the Jan. 3 issue of the British Journal of Urology International.

3 Jan 2013

Itch-specific nerve cells in skin discovered by John Hopkins scientists

Johns Hopkins researchers have uncovered strong evidence that mice have a specific set of nerve cells that signal itch but not pain, a finding that may settle a decades-long debate about these sensations, and, if confirmed in humans, help in developing treatments for chronic itch, including itch caused by life-saving medications.

3 Jan 2013

Trovagene, MD Anderson partner to detect transrenal BRAF mutations in metastatic cancers

Trovagene, Inc., a developer of transrenal molecular diagnostics, announced that it has entered into a clinical collaboration with The University of Texas MD Anderson Cancer Center to detect transrenal BRAF mutations in the urine of patients with advanced or metastatic cancers.

3 Jan 2013

18F-FDG PET/CT may become important distant staging modality in patients with breast cancer

New research published in the January issue of The Journal of Nuclear Medicine shows that 18F-fludeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging offers significant prognostic stratification information at initial staging for patients with locally advanced breast cancer. When compared to conventional imaging, 18F-FDG PET/CT more accurately showed lesions in the chest, abdomen and bones in a single session, changing management for more than 50 percent of the patients in the study.

3 Jan 2013

CXCR5 molecule effectively polices lung tuberculosis and prevents deadly infection

The presence of a certain molecule allows the immune system to effectively police tuberculosis (TB) of the lungs and prevent it from turning into an active and deadly infection, according to a new study led by researchers at Children's Hospital of Pittsburgh of UPMC and the University of Pittsburgh School of Medicine.

3 Jan 2013

Psychiatric patients at risk of hospitalization due to protected records

Medical centers that elect to keep psychiatric files private and separate from the rest of a person's medical record may be doing their patients a disservice, a Johns Hopkins study concludes.

3 Jan 2013

No significant difference in patient outcomes with RBC transfusions using lower threshold levels

The level at which red blood cells are transfused, a common treatment in clinical practice, is often deliberated among physicians. Guidelines for blood transfusion levels were only recently issued in March 2012 diminishing some of the debate. Today, in a new section called JAMA Clinical Evidence Synopsis, the Journal of the American Medical Association (JAMA), published a summary of the systematic review of the 19 clinical trials that compare higher versus lower hemoglobin thresholds in red blood cell transfusion.

3 Jan 2013

Regenerative medicine: an interview with Christophe Dardel, President of DSM Biomedical

Regenerative medicine is a new, exciting field that is based upon the belief that the human body has the inherent power to heal itself, but in some instances it just needs a little help.

3 Jan 2013

New Wiley handbook offers well-designed approach to imaging musculoskeletal trauma

Imaging Musculoskeletal Trauma: A Handbook for the Clinic, published by Wiley, offers a well-designed approach to imaging musculoskeletal trauma.

3 Jan 2013

Medicine News and Research

Chromatin regulation not governed by a uniform histone code

Statin therapy affects muscles’ energy production

New insight into 22q11.2 deletion syndrome

New rat model simulates traumatic or surgical muscle tissue loss in humans

Top 4 reasons why many dieters do not lose weight

Scientists discover process by which mda-9/syntenin contributes to melanoma metastasis

The Joint Commission, AHA/ASA recognize HUP with Comprehensive Stroke Center Certification

Scientists demonstrate importance of Plvap gene in mammalian physiology

Researchers analyze impact of 3 unexpected sex determination factors

Longer looks: DIY abortions and the law; Helping other parents reach out to mentally ill children; Human growth hormone and Big Pharma

Comorbid Axis I disorders highly prevalent in mood disorder patients

Partin Tables to predict prostate cancer spread now updated

Itch-specific nerve cells in skin discovered by John Hopkins scientists

Trovagene, MD Anderson partner to detect transrenal BRAF mutations in metastatic cancers

18F-FDG PET/CT may become important distant staging modality in patients with breast cancer

CXCR5 molecule effectively polices lung tuberculosis and prevents deadly infection

Psychiatric patients at risk of hospitalization due to protected records

No significant difference in patient outcomes with RBC transfusions using lower threshold levels

Regenerative medicine: an interview with Christophe Dardel, President of DSM Biomedical

New Wiley handbook offers well-designed approach to imaging musculoskeletal trauma

Everything there is to know about biosimilars eBook

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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