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Bariatric surgery successes pave way for new type 2 diabetes treatment

Bariatric surgery has long yielded almost immediate health benefits for patients with type 2 diabetes, and new findings on the reasons for remission may be the key to developing drug alternatives to surgery.

25 Apr 2018

Study compares survival outcomes of different drugs for type 2 diabetes

In a comparison of different classes of drugs used to lower blood sugar levels for patients with type 2 diabetes, sodium-glucose cotransporter 2 (SGLT-2) inhibitors or glucagon-like peptide 1(GLP-1) agonists were associated with a lower risk of death than dipeptidyl peptidase 4 (DPP-4) inhibitors or control (placebo or no treatment).

17 Apr 2018

One class of diabetes drug not associated with reduced risk of death

One class of drug used to treat type 2 diabetes may not reduce the risk of death when compared with placebo, suggests new findings.

17 Apr 2018

New diabetes drug may help obese people shed body weight

A compound that mimics a naturally occurring hormone that regulates appetite may help people who have obesity but not diabetes to lose weight, a new study suggests.

19 Mar 2018

Scientists uncover detailed map of the brain circuits behind thirst and satiety

Scientists uncovered a high-resolution map of the wiring inside the mouse brain's thirst center. With these blueprints, they could trick mice into becoming light or heavy water drinkers.

8 Mar 2018

New study identifies the body's 'glucostat'

It is the pancreatic islets that have the overall responsibility for maintaining normal blood glucose levels in our bodies, according to a new study by researchers at Karolinska Institutet in Sweden and the University of Miami Miller School of Medicine, USA.

6 Mar 2018

Gastric bypass can provide better outcomes for patients with obesity and diabetes than lifestyle intervention

People with worrisome levels of obesity and poor control of their type 2 diabetes face two dramatically different options to substantially improve their health: bariatric (weight loss) surgery or intensive lifestyle management.

2 Mar 2018

Chemist finds how to control blood sugar without usual side effects

Chemist Robert Doyle in the College of Arts and Sciences at Syracuse University has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

11 Feb 2018

Newly solved glucagon receptor structure provides most accurate template for drug design

Class B G protein-coupled receptors (GPCRs) exert essential action in hormonal homeostasis and are important therapeutic targets for a variety of diseases including metabolic disorders such as type 2 diabetes.

4 Jan 2018

Diabetes drug holds promise of being developed into new treatment for Alzheimer's

A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice through a triple method of action.

2 Jan 2018

Scientists take step toward solving puzzle about heart health in type 2 diabetes

Scientists at Joslin Diabetes Center have taken another step toward solving a long-standing puzzle about heart health in type 2 diabetes, with a finding that eventually may point towards more personalized patient care.

29 Nov 2017

UB researcher explores link between signals in the brain's reward system and overeating, drug addiction

Why are some people able to stop after eating just a few potato chips, while others aren't satisfied until the bag is nothing but crumbs? The answer may lie in the signals acting in the brain's reward system.

9 Nov 2017

New discovery in beta-cell pathway shows potential to improve effectiveness of diabetes drugs

Over the past 15 years, University of Alabama at Birmingham endocrinologist Anath Shalev, M.D., has unraveled a crucial biological pathway that malfunctions in diabetes.

8 Nov 2017

Research sheds light on how to improve production of key diabetes cells

Beta cells release insulin in your blood, but when you suffer from Type 1 diabetes, you hardly have any of them left in your body. This is because the immune system attacks the beta cells.

21 Sep 2017

Increased enzyme production by the liver causes fatty liver, obesity and insulin resistance

In mice that are given a high-fat diet, an increased production of the enzyme DPP4 by the liver promotes an increase in body fat, the development of fatty liver disease and insulin resistance.

24 Aug 2017

Common obesity and diabetes drug could be used as novel way to lower brain pressure

Research led by the University of Birmingham, published today in Science Translational Medicine, has discovered that a drug commonly used to treat patients with either obesity or Type II diabetes could be used as a novel new way to lower brain pressure.

23 Aug 2017

Diabetes drug shows promise as Parkinson’s treatment

A drug commonly used to treat diabetes could help people living with Parkinson’s disease, say researchers.

7 Aug 2017

Gene-therapy administered through skin transplants could enable treatment of many diseases

A research team based at the University of Chicago has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat many human diseases.

3 Aug 2017

Scientists show how muscles request more energy from fat storage tissues

Muscles require energy to perform all of the movements that we do in a day, and now, for the first time, researchers at the Texas A&M College of Medicine have shown how muscles "request" more energy from fat storage tissues in fruit fly models.

6 Jul 2017

Researchers capture first cryo-EM snapshots of key cellular receptor in action

Researchers at the University of Michigan, Stanford University and biotech company ConfometRx have captured the first cryo-electron microscopy snapshots of a key cellular receptor in action.

25 May 2017