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Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

A novel gene therapy using CRISPR genome editing technology effectively targets cancer-causing "fusion genes" and improves survival in mouse models of aggressive liver and prostate cancers, University of Pittsburgh School of Medicine researchers report in a study published online today in Nature Biotechnology.

2 May 2017

Stivarga receives expanded FDA approval for treatment of liver cancer

The U.S. Food and Drug Administration today expanded the approved use of Stivarga (regorafinib) to include treatment of patients with hepatocellular carcinoma (HCC or liver cancer) who have been previously treated with the drug sorafenib.

28 Apr 2017

VUMC researcher receives grant to test efficacy of drug for reversing precancerous stomach lesions

Vanderbilt University Medical Center cancer researcher James Goldenring, M.D., Ph.D., has received a two-year, $200,000 grant from the DeGregorio Family Foundation in Pleasantville, New York, to begin clinical trials of a potential approach for reversing precancerous stomach lesions.

28 Apr 2017

Findings could lead to new treatments for people who overdose on popular pain reliever

Results from a new study show that after an acetaminophen overdose the p53 protein plays a key role in preventing the progression of liver damage and signaling the liver to repair itself.

27 Apr 2017

Researchers take important step toward using transplanted fetal cells to treat liver failure

In a new study, researchers demonstrate successful transplantation of fetal rat liver cells to an injured adult rat liver. The work is an important step toward using transplanted cells to treat liver failure, which currently requires an organ transplant.

26 Apr 2017

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson's disease.

26 Apr 2017

Obesity amplifies effects of three risk alleles linked to NAFLD

An international study based at UT Southwestern Medical Center revealed a striking genetic-environmental interaction: Obesity significantly amplifies the effects of three gene variants that increase risk of nonalcoholic fatty liver disease by different metabolic pathways.

26 Apr 2017

Study reveals promising results for primary liver cancer patients treated with SIR-Spheres Y-90 resin microspheres

Patients with advanced or inoperable Hepatocellular Carcinoma (HCC) who usually received one or two treatments with liver-directed SIR-Spheres Y-90 resin microspheres in the 459-patient French SARAH study had similar survival compared to patients who received standard twice-daily systemic treatment with sorafenib, but with less than half the number and significantly fewer severe treatment-related adverse effects and significantly better Quality of Life, according to data presented here at The International Liver Congress™ 2017.

26 Apr 2017

Vitamin A combined with high-fat diet may lead to increased risk for obesity and diabetes

Vitamin A is an essential nutrient that the human body needs to function properly. But new research presented today at the American Physiological Society annual meeting at Experimental Biology 2017 in Chicago suggests that normal levels of vitamin A within a high-fat diet can negatively affect expression of liver genes associated with glucose and fat metabolism.

26 Apr 2017

Enzyme treatment may prevent or reduce liver damage caused by excess alcohol consumption

An intestinal enzyme previously shown to keep bacterial toxins from passing from the gastrointestinal system into the bloodstream may be able to prevent or reduce the liver damage caused by excess alcohol consumption.

25 Apr 2017

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Imagine this scenario on a highway: A driver starts to make a sudden lane change but realizes his mistake and quickly veers back, too late. Other motorists have already reacted and, in some cases, collide. Meanwhile, the original motorist - the one who caused the problem - drives on.

25 Apr 2017

Statins may provide favorable outcomes to patients with HBV- or HCV-related cirrhosis

Infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) can lead to cirrhosis as well as liver cancer. A Hepatology study from Taiwan has found that statins may provide benefits to patients with HBV- or HCV-related cirrhosis.

24 Apr 2017

High-fat diet and obesity drive liver immune cells to promote metabolic syndrome

A high-fat diet and obesity turn "hero" virus-fighting liver immune cells "rogue", leading to insulin resistance, a condition that often results in type 2 diabetes, according to research published today in Science Immunology.

21 Apr 2017

Sunflower seeds contaminated by toxic molds pose increased health risks

Michigan State University researchers have shown that sunflower seeds are frequently contaminated with a toxin produced by molds and pose an increased health risk in many low-income countries worldwide.

21 Apr 2017

Sugary drinks may impact memory and diet alternatives could cause dementia

New research, published in both Alzheimer's & Dementia and Stroke indicate that drinking sugary drinks regularly may lead to a reduction in the size of the brain and poorer memory.

21 Apr 2017

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

Stem cell transplants can save lives, for example in patients with leukemia. However, these treatments are not free of risks. One complication that may occur is graft-versus-host disease (GVHD), basically donor-derived immune cells attacking the recipient’s body.

21 Apr 2017

WHO Global Hepatitis Report reveals goal to eliminate viral hepatitis by 2030

The World Health Organization (WHO) has published the first-ever Global Hepatitis Report. The World Hepatitis Alliance (WHA) welcomes the publication, which is a follow-up to WHO’s Global Strategy on Viral Hepatitis, and has set the goal to eliminate viral hepatitis as a public health threat by 2030.

21 Apr 2017

Spermidine supplement may prolong lifespan, prevent liver fibrosis and cancer

Spermidine - a compound found in foods like aged cheese, mushrooms, soy products, legumes, corn and whole grains - seems to prevent (at least in animal models) liver fibrosis and hepatocellular carcinoma, which is the most common type of liver cancer. There is also some evidence that it may prolong lifespan, according to a study published recently in the journal Cancer Research.

20 Apr 2017

Endoscopic sleeve gastroplasty found to be safe and effective way for treating obese patients

A new weight loss procedure that reduces the size of the stomach without the need for surgery known as endoscopic sleeve gastroplasty is safe and effective way for the treatment obesity and obesity-related comorbidities such as diabetes, high blood pressure, and fatty liver, according to a new study by NewYork-Presbyterian and Weill Cornell Medicine researchers.

20 Apr 2017

Periodic check-ups are essential to maintain health and longevity of baby boomers

For some baby boomers, getting ready for a routine visit with their doctor is like training for a marathon. Some patients want to be in the best shape possible before stepping on that scale and getting those lab results.

19 Apr 2017

Liver News and Research

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

Stivarga receives expanded FDA approval for treatment of liver cancer

VUMC researcher receives grant to test efficacy of drug for reversing precancerous stomach lesions

Findings could lead to new treatments for people who overdose on popular pain reliever

Researchers take important step toward using transplanted fetal cells to treat liver failure

Study underscores need for genetic screening to improve safety of experimental stem cell treatments

Obesity amplifies effects of three risk alleles linked to NAFLD

Study reveals promising results for primary liver cancer patients treated with SIR-Spheres Y-90 resin microspheres

Vitamin A combined with high-fat diet may lead to increased risk for obesity and diabetes

Enzyme treatment may prevent or reduce liver damage caused by excess alcohol consumption

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Statins may provide favorable outcomes to patients with HBV- or HCV-related cirrhosis

High-fat diet and obesity drive liver immune cells to promote metabolic syndrome

Sunflower seeds contaminated by toxic molds pose increased health risks

Sugary drinks may impact memory and diet alternatives could cause dementia

Researchers develop new approach to protect stem cell recipients from graft-versus-host disease

WHO Global Hepatitis Report reveals goal to eliminate viral hepatitis by 2030

Spermidine supplement may prolong lifespan, prevent liver fibrosis and cancer

Endoscopic sleeve gastroplasty found to be safe and effective way for treating obese patients

Periodic check-ups are essential to maintain health and longevity of baby boomers

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Bringing real-time analytics to downstream bioprocess monitoring

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Evaluating new approaches for rare disease genomics

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