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New insights on replication-stress sensitivity in breast cancer cells

Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1.

28 Jul 2021

Higher temperatures could limit the spread of dengue infection

Infection with dengue virus makes mosquitoes more sensitive to warmer temperatures, according to new research led by Penn State researchers.

27 Jul 2021

Bye-bye to health insurance ‘birthday rule’? Kansas lawmaker floats fix

When Kayla Kjelshus gave birth to her first child, the infant spent seven days in the neonatal intensive care unit, known as the NICU.

27 Jul 2021

SARS-CoV-2 interacts with unusual RNA structures in human cells

The study, published in the journal Nucleic Acids Research, demonstrated that G4 ligands, the chemical that binds with G4s, prevent this interaction. The results could pave the way for developing inhibitors of these interactions as potential antiviral compounds.

26 Jul 2021

‘Social prescribing’ may help lonely older adults to avoid harmful sedatives and painkillers

Lonely, older adults are nearly twice as likely to use opioids to ease pain and two-and-a-half times more likely to use sedatives and anti-anxiety medications, putting themselves at risk for drug dependency, impaired attention, falls and other accidents, and further cognitive impairment, according to a study by researchers at UC San Francisco.

26 Jul 2021

Mount Sinai researchers use cerebral organoids to study frontotemporal dementia

Frontotemporal dementias are a group of fatal and debilitating brain disorders for which there are no cures.

26 Jul 2021

Nurses face increased likelihood of burnout during COVID-19, reports study

Early in the COVID-19 pandemic, more than 40 percent of nurses and other health care workers had risks associated with an increased likelihood of burnout, reports a survey study in the August issue of the American Journal of Nursing.

22 Jul 2021

Exoskeletons designed to reduce lower back pain may compete with valuable resources in the brain

Exoskeletons - wearable devices used by workers on assembly lines or in warehouses to alleviate stress on their lower backs - may compete with valuable resources in the brain while people work, canceling out the physical benefits of wearing them, a new study suggests.

22 Jul 2021

Structural home repairs in low-income neighborhoods linked with reduced crime rates

Investing in structural home repairs in historically segregated, low-income, Black, and Latino neighborhoods have been associated with reduced crime rates.

22 Jul 2021

Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.

22 Jul 2021

Study evaluates ICU workers' mental health during the COVID-19 pandemic

A high proportion of staff working in intensive care units during the COVID-19 pandemic have experienced mental health conditions, according to a new study.

21 Jul 2021

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal epithelium, finding great heterogeneity in the susceptibility of the organoids and the cells within to infection.

21 Jul 2021

Study associates feelings of discrimination and low status with long COVID-19 symptoms

A recent study, released as a preprint on the medRxiv* server, examines the correlation of these symptoms with the patient’s socioeconomic status (SES) and perception of social discrimination, along with other social factors. The researchers found that the first two factors are associated strongly with long-term symptoms of COVID-19.

21 Jul 2021

Knowledge and support from primary care services can improve women's health during menopause

More knowledge and individual support from primary care services can alleviate women's menopausal problems, a University of Gothenburg thesis shows.

21 Jul 2021

New substance derived from Saussurea controversa exhibits osteoprotective properties

Metabolic bone diseases, including osteoporosis, when bones lose their mass and become so fragile that they could be damaged while sneezing or under little stress, are called the silent epidemic of the 21st century.

20 Jul 2021

Scientists identify key role of p38-MK2 pathway in determining cell fate in response to stress

Living organisms are often exposed to stress stimuli generated either by external or internal factors, and they need to respond accordingly.

20 Jul 2021

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Russian scientists have synthesized chemical compounds that can stop the degeneration of neurons in Alzheimer's, Parkinson's, and other severe brain pathologies. These substances can provide a breakthrough in the treatment of neurodegenerative pathologies.

19 Jul 2021

Countries most susceptible to toxic pollution are also at highest risk from the impacts of global climate change

Mapping the global distribution of toxic pollution alongside the effects of climate change shows the same countries are most vulnerable to both.

19 Jul 2021

Central amygdala micro-circuits play active role in regulation of fear responses

The brain mechanisms underlying the suppression of fear responses have attracted a lot of attention as they are relevant for therapy of human anxiety disorders.

16 Jul 2021

Psychiatric patients have higher odds of hospitalization and death following COVID-19

In the largest systematic review and meta-analysis to date on COVID-19 outcomes in individuals with psychiatric disorders, the odds of dying or being hospitalized following COVID-19 infection were determined to be twice as high in comparison to persons without mental disorders.

16 Jul 2021

Stress News and Research

New insights on replication-stress sensitivity in breast cancer cells

Higher temperatures could limit the spread of dengue infection

Bye-bye to health insurance ‘birthday rule’? Kansas lawmaker floats fix

SARS-CoV-2 interacts with unusual RNA structures in human cells

‘Social prescribing’ may help lonely older adults to avoid harmful sedatives and painkillers

Mount Sinai researchers use cerebral organoids to study frontotemporal dementia

Nurses face increased likelihood of burnout during COVID-19, reports study

Exoskeletons designed to reduce lower back pain may compete with valuable resources in the brain

Structural home repairs in low-income neighborhoods linked with reduced crime rates

Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Study evaluates ICU workers' mental health during the COVID-19 pandemic

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Study associates feelings of discrimination and low status with long COVID-19 symptoms

Knowledge and support from primary care services can improve women's health during menopause

New substance derived from Saussurea controversa exhibits osteoprotective properties

Scientists identify key role of p38-MK2 pathway in determining cell fate in response to stress

New compounds can provide a breakthrough in the treatment of neurodegenerative pathologies

Countries most susceptible to toxic pollution are also at highest risk from the impacts of global climate change

Central amygdala micro-circuits play active role in regulation of fear responses

Psychiatric patients have higher odds of hospitalization and death following COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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