Enzyme News and Research

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Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, currently lacking effective treatment.

30 Jan 2018

Scientists discover how gene mutation affects T cell function to promote immune disorders

Scientists discovered how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery - successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia.

30 Jan 2018

Computational approach can help identify chemoresistant potential targets in cancer stem cells

In cancer, one of the most important features is the methylation of deoxycytosine to form 5-methylcytosine (5mC). DNA methylation is a process by which methyl groups (structural units of organic compounds consisting of three hydrogen atoms bonded to a carbon atom) are added to the DNA molecule.

30 Jan 2018

Soy milk found to be most nutritious among various types of plant-based milk

How healthy is your almond milk really? It may taste good and may not cause you any of the unpleasant reactions caused by cow's milk.

29 Jan 2018

Viral replication process weak spot may help develop cure for infections

Researchers at the Morgridge Institute for Research believe they have identified a weak spot in the replication process of positive-strand RNA viruses, which could yield treatment for viral infections such as Zika, Polio, Chikungunya, Hepatitis C and even common cold viruses.

29 Jan 2018

Scientists decipher molecular mechanism of the cell with relevance for cancer development

Achievement in the field of cancer research: Biologists and chemists at the University of Konstanz decipher a molecular mechanism of the cell with relevance for the development of cancer and the fight against that disease.

27 Jan 2018

Sugar-attaching enzyme found to be abundant in colon cancer cells

Researchers have identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells, according to a report in the Jan. 26 issue of the Journal of Biological Chemistry.

27 Jan 2018

Researchers working to fill knowledge gap between DNA damage and cancer

Researchers at The University of Kansas Cancer Center are working to fill the knowledge gap between DNA damage and cancer, including developing approaches to manipulate the DNA damage response to treat and prevent disease.

27 Jan 2018

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

Abnormalities in glucose uptake by the liver (or hepatic glucose uptake; HGU) cause elevations in blood glucose levels following meals, a state that is known as postprandial hyperglycemia.

27 Jan 2018

Scientists discover promising new target to fight a class of viruses

Scientists at the Morgridge Institute for Research have discovered a promising new target to fight a class of viruses responsible for health threats such as Zika, polio, dengue, SARS and hepatitis C.

25 Jan 2018

Researchers identify promising new drug target for Ewing sarcoma

Screening a class of recently-developed drug compounds -- so-called "CDK inhibitors" capable of blocking CDK7/12/13 proteins -- against hundreds of different human cancer cell lines, researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center have found that CDK12 inhibitors pack a particularly lethal punch to Ewing sarcoma, a rare cancer typically affecting children and young adults.

25 Jan 2018

Researchers develop ultra-thin, flexible biosensor for real-time glucose tracking

Constantly tracking a person's glucose levels through their tears or sweat could be one step closer to providing people with diabetes an improved monitoring tool.

24 Jan 2018

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

New research from Sanford Burnham Prebys Medical Discovery Institute is among the first to describe how an mRNA modification impacts the life of neural stem cells.

24 Jan 2018

Enzyme inhibitor and chemotherapy combination regresses glioblastoma

In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide.

24 Jan 2018

Scientists elucidate surprising dual function of ceramide synthase

Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ability to turn genes involved in lipid metabolism on or off. The study is being published in the renowned journal Cell Reports.

24 Jan 2018

Combination chemotherapy increases survival in animal models of glioblastoma

A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years.

23 Jan 2018

Scientists take tissue-engineering approach to improve healing related to skeletal system

"Take a knee." "On bended knee." A "knee-slapper." "The bee's knees." The knee certainly carries a lot of weight in the English language, just as it does in the body. As the largest and one of the most complicated joints, the knee is also one of the most easily injured.

23 Jan 2018

Anti-inflammatory pill could help make vaccines more effective for the elderly

By identifying why skin immunity declines in old age, a UCL-led research team has found that an anti-inflammatory pill could help make vaccines more effective for elderly people.

22 Jan 2018

Enzyme discovery provides new horizon of therapeutic opportunities across disease spectrum

Doctors have long treated heart attacks, improved asthma symptoms, and cured impotence by increasing levels of a single molecule in the body: nitric oxide.

19 Jan 2018

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Researchers from the Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute, led by Dr. Àlex Vaquero, have proposed a new regulation mechanism of the NF-κB pathway, which is associated with accelerated cellular aging, based on the analysis of the function of the SirT6 protein.

19 Jan 2018

Enzyme News and Research

Researchers use gene therapy that lengthens telomeres to cure pulmonary fibrosis in mice

Scientists discover how gene mutation affects T cell function to promote immune disorders

Computational approach can help identify chemoresistant potential targets in cancer stem cells

Soy milk found to be most nutritious among various types of plant-based milk

Viral replication process weak spot may help develop cure for infections

Scientists decipher molecular mechanism of the cell with relevance for cancer development

Sugar-attaching enzyme found to be abundant in colon cancer cells

Researchers working to fill knowledge gap between DNA damage and cancer

Researchers identify potential enzyme as therapeutic target for type 2 diabetes

Scientists discover promising new target to fight a class of viruses

Researchers identify promising new drug target for Ewing sarcoma

Researchers develop ultra-thin, flexible biosensor for real-time glucose tracking

Discovery may advance stem cell therapies, gene-targeting treatments for neurological diseases

Enzyme inhibitor and chemotherapy combination regresses glioblastoma

Scientists elucidate surprising dual function of ceramide synthase

Combination chemotherapy increases survival in animal models of glioblastoma

Scientists take tissue-engineering approach to improve healing related to skeletal system

Anti-inflammatory pill could help make vaccines more effective for the elderly

Enzyme discovery provides new horizon of therapeutic opportunities across disease spectrum

Researchers propose new regulation mechanism linked to action of SirT6 on chromatin

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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