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Russian scientists uncover previously unknown effect of leukemia drug

Researchers from RUDN University and Institute of Biomedical Chemistry of the Russian Academy of Sciences have identified an alternative mechanism for the effective antitumor drug -- an enzyme called L-asparaginase.

10 Nov 2017

Scientists pinpoint new wake-promoting neurons in the brain

Scientists have identified an additional group of cells in the brain responsible for keeping us awake: the supramammillary nucleus, part of the caudal hypothalamus.

10 Nov 2017

Researchers catch killer cells red-handed in the act of microbial murder

Immune cells called "killer cells" target bacteria invading the body's cells, but how do they do this so effectively? Bacteria can quickly evolve resistance against antibiotics, yet it seems they have not so readily been able to evade killer cells. This has caused researchers to become interested in finding out the exact mechanism that killer cells use to destroy bacterial invaders.

9 Nov 2017

Study finds link between increased brain glucose levels and Alzheimer's

A new study published yesterday in Alzheimer's & Dementia: the Journal of the Alzheimer's Association, found a link for the first time between abnormalities in the mechanism of glucose breakdown in the brain and the severity of tangles and amyloid plaques in the brain, as well as the commencement of visible symptoms of Alzheimer's disease.

7 Nov 2017

Researchers identify mechanisms through which H. pylori bacteria cause gastric cancer

Gastric cancer is one of the five most fatal types of cancer. According to the statistics of the World Health Organization, about 750,000 patients die each year after developing the disease. The main cause is thought to be the bacterium Helicobacter pylori (H. pylori).

7 Nov 2017

Researchers discover how traffic jam in intracellular sorting can cause tumor development

For tissues to cooperate and perform normal functions, cells need to know which way is up. When cells lose track of their orientation, they can start to grow out of control, and develop into cancer.

6 Nov 2017

New study elucidates osteoblast production during bone regeneration

How osteoblasts are supplied during bone regeneration has been controversial among bone researchers. According to Atsushi Kawakami, an Associate Professor who specializes in tissue regeneration and led the study, scientists disagree on how these cells are made.

3 Nov 2017

Russian scientists design new compounds that can treat glaucoma

Glaucoma is a serious disease associated with increased intraocular pressure which often leads to blindness. One of the ways to treat glaucoma is to reduce aqueous humour secretion in the ciliary body of the eye by suppressing (inhibiting) activity of special enzymes - carbonic anhydrases.

3 Nov 2017

An alternative approach to augmenting the effect of antibiotics in chronic CF lung infections

There are about 77,000 people known to have cystic fibrosis. That's from the various cystic fibrosis registries available globally. The World Health Organization suggests that this number may be low, because there's no reporting on cystic fibrosis from the developing world. The accepted number, at the moment, is about 80,000. That's the one that is used for most of the work that's being done on cystic fibrosis.

From Neem Biotech 3 Nov 2017

Researchers discover mechanism that controls release of molecules involved in inflammatory diseases

In a recent study published in Cell Reports, a research team led by Colin Adrain, from the Instituto Gulbenkian de Ciência, discovered the mechanism that controls the release of important molecules that trigger the inflammatory response during the clearance of infections.

2 Nov 2017

Research may explain why gum disease is linked to heart problems

Heart disease and fatty clogs in the arteries go hand in hand. But new evidence suggests the fatty molecules might come not only from what you eat, but from the bacteria in your mouth, report UConn scientists in the 16 August issue of the Journal of Lipid Research.

1 Nov 2017

Scientists solve decade-old mystery that could lead to development of new treatments for TB

Scientists have solved a decade-old mystery that could eventually lead to the development of earlier treatments for one of the world's deadliest diseases, which affects up to 2 billion people.

1 Nov 2017

Gut bacteria composition could predict toxicity of chemotherapy drugs in cancer patients

Albert Einstein College of Medicine researchers report that the composition of people's gut bacteria may explain why some of them suffer life-threatening reactions after taking a key drug for treating metastatic colorectal cancer.

1 Nov 2017

Neutron crystallography study could open avenues for new drugs to battle diseases

Scientists at the Department of Energy’s Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant tuberculosis, malaria, and diabetes.

1 Nov 2017

Research sheds light on how bones affect appetite and metabolism

Your skeleton is much more than the structure supporting your muscles and other tissues. It produces hormones, too. And Mathieu Ferron knows a lot about it.

1 Nov 2017

FDA grants accelerated approval to new treatment for mantle cell lymphoma

The U.S. Food and Drug Administration today granted accelerated approval to Calquence (acalabrutinib) for the treatment of adults with mantle cell lymphoma who have received at least one prior therapy.

1 Nov 2017

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

The Global Health Innovative Technology Fund, a unique Japanese public-private partnership formed to battle infectious diseases around the globe, today announced US$16.7 million to support development of new compounds for fighting malaria and tuberculosis, a leishmaniasis vaccine and drug, and a treatment for a long-ignored flesh-eating infection.

31 Oct 2017

Researchers produce 3D map of molecular 'scaffold' known to play key role in cancers

Researchers have produced the first three-dimensional (3D) map of a molecular 'scaffold' called SgK223, known to play a critical role in the development and spread of aggressive breast, colon, and pancreatic cancers.

30 Oct 2017

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Candida albicans is a notorious human fungal pathogen that causes thrush and serious systemic infections. Opportunistic C. albicans fungi, which often live inconspicuously in the normal flora of human skin and gut, can switch from their harmless stealth mode to become aggressive pathogens, especially in people whose immune systems are already compromised by pre-existing diseases or harsh drug therapies.

30 Oct 2017

Researchers identify important mechanism of epigenetic gene regulation

How can defective gene activity, which can ultimately lead to cancer, be avoided? Researchers at the University of Zurich have now identified a mechanism how cells pass on the regulation of genetic information through epigenetic modifications. These insights open the door to new approaches for future cancer treatments.

30 Oct 2017

Enzyme News and Research

Russian scientists uncover previously unknown effect of leukemia drug

Scientists pinpoint new wake-promoting neurons in the brain

Researchers catch killer cells red-handed in the act of microbial murder

Study finds link between increased brain glucose levels and Alzheimer's

Researchers identify mechanisms through which H. pylori bacteria cause gastric cancer

Researchers discover how traffic jam in intracellular sorting can cause tumor development

New study elucidates osteoblast production during bone regeneration

Russian scientists design new compounds that can treat glaucoma

An alternative approach to augmenting the effect of antibiotics in chronic CF lung infections

Researchers discover mechanism that controls release of molecules involved in inflammatory diseases

Research may explain why gum disease is linked to heart problems

Scientists solve decade-old mystery that could lead to development of new treatments for TB

Gut bacteria composition could predict toxicity of chemotherapy drugs in cancer patients

Neutron crystallography study could open avenues for new drugs to battle diseases

Research sheds light on how bones affect appetite and metabolism

FDA grants accelerated approval to new treatment for mantle cell lymphoma

GHIT Fund announces US$16.7 million to support development of new drugs, vaccines and diagnostics

Researchers produce 3D map of molecular 'scaffold' known to play key role in cancers

New gene drive approach helps pinpoint combination therapies against fungal pathogens

Researchers identify important mechanism of epigenetic gene regulation

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