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Gene therapy reduces hearing loss associated with Norrie disease in mice

An international team led by researchers at UCL and the NIHR Great Ormond Street Hospital Biomedical Research Centre have developed in mice a gene therapy that significantly reduces the hearing loss associated with Norrie disease.

29 Aug 2023

Drug-encapsulated nanogels show potential for treating obesity and other liver diseases

A University of Massachusetts Amherst biomedical engineer has used a nanogel-based carrier designed in his lab to deliver a drug exclusively to the liver of obese mice, effectively reversing their diet-induced disease.

29 Aug 2023

Natriuresis-guided diuretic therapy improves decongestion in acute heart failure

A pragmatic natriuresis-guided diuretic approach in patients with acute heart failure significantly increases 24-hour natriuresis without impacting all-cause mortality or heart failure rehospitalization, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

Extended P2Y12 inhibitor monotherapy reduces bleeding and ischemic events in ACS patients

Extended P2Y12 inhibitor monotherapy beyond 12 months after percutaneous coronary intervention (PCI) reduces bleeding and ischemic events in acute coronary syndrome (ACS) patients at high risk for both types of events.

29 Aug 2023

Early initiation of dapagliflozin in acute decompensated heart failure does not improve diuretic efficiency

Early initiation of the sodium glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin did not result in a statistically significant improvement in diuretic efficiency relative to structured usual care in hospitalized patients with acute decompensated heart failure (ADHF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

Longer duration of anticoagulation therapy benefits cancer patients with isolated distal DVT

Twelve months of edoxaban is superior to three months for the reduction of thrombotic events in patients with cancer and distal deep vein thrombosis (DVT), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

29 Aug 2023

£5 million awarded to 12 projects aimed at tackling fatal drug overdoses

12 projects awarded a share of £5 million to reduce rates of fatal drug overdoses, as part of Vaccine Taskforce style approach to tackle health challenges.

29 Aug 2023

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Researchers investigated whether bone marrow-derived cells contribute to colitis-associated colon cancer.

29 Aug 2023

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.

28 Aug 2023

Study challenges the use of biochemical recurrence as prostate cancer predictor

A UCLA-led study found treatments that reduce the risk of being diagnosed with a cancer recurrence based on rising prostate-specific antigen (PSA) levels after radiotherapy, commonly referred to as biochemical recurrence, do not necessarily improve a patient's long-term overall survival.

28 Aug 2023

Scientific breakthrough could someday save the lives of children with rhabdomyosarcoma

"Every successful medicine has its origin story. And research like this is the soil from which new drugs are born," says Cold Spring Harbor Laboratory Professor Christopher Vakoc.

28 Aug 2023

ECLS does not improve survival in patients with acute myocardial infarction complicated by cardiogenic shock

Early extracorporeal life support (ECLS) does not improve survival in patients with acute myocardial infarction complicated by cardiogenic shock who are scheduled for early revascularization, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Pulsed field ablation safe, effective for the treatment of paroxysmal atrial fibrillation

Pulsed field ablation (PFA) is as effective and safe as conventional thermal ablation for the treatment of paroxysmal atrial fibrillation (AF), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Acoramidis shows potential to be effective, safe treatment for transthyretin amyloid cardiomyopathy

Acoramidis improves outcomes in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) compared with placebo, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Ablation more effective than medical therapy in patients with end-stage heart failure, study shows

Atrial fibrillation ablation is associated with lower rates of death, urgent heart transplantation or left ventricular assist device (LVAD) implantation compared with medical therapy in patients with end-stage heart failure, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Obese adults with ARDS may benefit from ECMO

A National Institutes of Health-supported study suggests that adults with obesity may benefit from the use of extracorporeal membrane oxygenation (ECMO), an advanced form of breathing support, when in intensive care for respiratory failure.

28 Aug 2023

Dual-antiplatelet therapy should remain the standard strategy for PCI even in the drug-eluting stent era

Prasugrel monotherapy after percutaneous coronary intervention (PCI) with drug-eluting stents is not superior to dual-antiplatelet therapy (DAPT) for major bleeding but is non-inferior for cardiovascular events in patients with acute coronary syndrome (ACS) or high bleeding risk (HBR), according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

CRT-D upgrade reduces morbidity and mortality in HFrEF patients with RV pacing

Upgrade to cardiac resynchronization therapy with a defibrillator (CRT-D) reduces morbidity and mortality and improves left ventricular (LV) reverse remodeling compared to an implantable cardioverter-defibrillator (ICD) in select patients with heart failure and reduced ejection fraction (HFrEF) and intermittent or permanent right ventricular (RV) pacing, according to late breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

Intravenous ferric carboxymaltose linked to lower risk of heart failure hospitalizations in iron-deficient patients

In iron-deficient patients with heart failure and reduced or mildly reduced left ventricular ejection fraction, intravenous ferric carboxymaltose (FCM) is associated with a reduced risk of the composite outcome of total cardiovascular hospitalization and cardiovascular death through 52 weeks compared with placebo, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023.

28 Aug 2023

PROFID EHRA trial to assess the potential benefit of ICD therapy in myocardial infarction survivors

Is the routine implantation of an implantable cardioverter defibrillator (ICD) in myocardial infarction survivors with heart failure still an adequate therapy for prevention of sudden cardiac death?

28 Aug 2023

Therapy News and Research

Gene therapy reduces hearing loss associated with Norrie disease in mice

Drug-encapsulated nanogels show potential for treating obesity and other liver diseases

Natriuresis-guided diuretic therapy improves decongestion in acute heart failure

Extended P2Y12 inhibitor monotherapy reduces bleeding and ischemic events in ACS patients

Early initiation of dapagliflozin in acute decompensated heart failure does not improve diuretic efficiency

Longer duration of anticoagulation therapy benefits cancer patients with isolated distal DVT

£5 million awarded to 12 projects aimed at tackling fatal drug overdoses

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

Study challenges the use of biochemical recurrence as prostate cancer predictor

Scientific breakthrough could someday save the lives of children with rhabdomyosarcoma

ECLS does not improve survival in patients with acute myocardial infarction complicated by cardiogenic shock

Pulsed field ablation safe, effective for the treatment of paroxysmal atrial fibrillation

Acoramidis shows potential to be effective, safe treatment for transthyretin amyloid cardiomyopathy

Ablation more effective than medical therapy in patients with end-stage heart failure, study shows

Obese adults with ARDS may benefit from ECMO

Dual-antiplatelet therapy should remain the standard strategy for PCI even in the drug-eluting stent era

CRT-D upgrade reduces morbidity and mortality in HFrEF patients with RV pacing

Intravenous ferric carboxymaltose linked to lower risk of heart failure hospitalizations in iron-deficient patients

PROFID EHRA trial to assess the potential benefit of ICD therapy in myocardial infarction survivors

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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