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New research may lead to future gene therapies for patients with sickle cell anemia and beta-thalassemia

Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have identified two proteins that are responsible for regulating overlapping groups of genes during the development of red blood cells.

7 Aug 2007

Scientists discover brain cell development process implicated in mental retardation

New Brunswick, N.J. , Scientists at Rutgers, The State University of New Jersey, have discovered a biological process in brain cell development that may help explain some causes of mental retardation.

1 Aug 2007

Scientists shed new light on how microRNAs carry out their function

MicroRNAs became the stars of the RNA universe when, in 2001, scientists found that these short RNAs can control whether or not genes are expressed.

27 Jul 2007

Ago2 and hematopoiesis

Argonaute 2 (Ago2) is unique among its family: It is the only one of the four mammalian Argonaute proteins that exhibits endonuclease 'slicer' activity (facilitation of miRNA-guided cleavage of target mRNA).

12 Jul 2007

Master switch for the production of brown fat discovered

Researchers at Dana-Farber Cancer Institute have identified a long-sought "master switch" in mice for the production of brown fat, a type of adipose tissue that generates heat and counters obesity caused by overeating.

11 Jul 2007

Abiogen licenses RFB4 antibody from Cancer Research Technology

Cancer Research Technology Limited (CRT), the oncology-focused development and commercialisation company, today announces it has agreed an exclusive worldwide licence with Abiogen Pharma S.p.A. (Italy).

11 Jul 2007

Researchers track how spores break out of dormant state

Tapping into the unknown world of awakening dormant bacterial spores, researchers have revealed through atomic force microscopy (AFM) the alterations of spore coat and germ cell wall that accompany the transformation from a spore to a vegetative cell.

5 Jun 2007

Researchers observe brain cell development in real time

For the first time anywhere, a researcher at the Hebrew University of Jerusalem has succeeded in observing in vivo the generation of neurons in the brain of a mammal.

28 May 2007

Yin Yang 1 regulates early B cell development

A new paper in the May 15th issue of Genes & Development reveals how a protein called Yin Yang 1 regulates early B cell development.

17 May 2007

Researchers design cell culture test for assessing a compound's genetic toxicity - cheaper than animal tests

In the daunting marathon that leads to successful drugs, promising drug candidates must pass toxicity tests before entering clinical trials.

15 May 2007

Study of planarians offers insight into germ cell development

The planarian is not as well known as other, more widely used subjects of scientific study , model creatures such as the fruit fly, nematode or mouse.

25 Apr 2007

Human bone marrow has been used to create early-stage sperm cells

For the experiment, Prof Nayernia and his team took bone marrow from male volunteers and isolated the mesenchymal stem cells. These cells have previously been found to grow into other body tissues such as muscle.

15 Apr 2007

Stem cells offer new ways of treating hearing loss

Have you ever walked by someone listening to their i-Pod loud enough for you recognize the song? Studies have shown noise-induced hearing loss is going to become the next big epidemic affecting our younger generation though the effects won't show until it is too late to treat.

7 Apr 2007

New regulatory mechanism for critical protein signaling domain

The study is being published in Science Express, an advanced online edition of the journal Science, on April 5. It will appear in the print version of Science later this spring.

7 Apr 2007

New discovery suggests novel methods for treating acute lymphoblastic leukemia

Investigators at St. Jude Children's Research Hospital have discovered previously unsuspected mutations that contribute to the formation of pediatric acute lymphoblastic leukemia (ALL), the most common cancer in children.

8 Mar 2007

Discovery about fatty tissue that burns fat

In an article now being published in the leading American journal PNAS, a research team led by Barbara Cannon and Jan Nedergaard at the Wenner-Gren Institute, Stockholm University in Sweden, together with British and American scientists, have managed to show for the first time that the cells that become the so-called brown or white fat tissue already know from the very beginning what sort of fat tissue they will be.

7 Mar 2007

New test identifies suitable lymphoma patients likely to respond to new therapy

Researchers at the Albert Einstein College of Medicine of Yeshiva University have discovered a genetic signature identifying cases of lymphoma that are uniquely susceptible to a newly developed molecular targeted therapy. As a result, physicians organizing clinical trials of the new therapy will be able to enroll patients who'll be most likely to benefit from it.

20 Feb 2007