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Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Researchers have described the potential of the drug spironolactone, a potassium-sparing diuretic, and anti-androgen, in preventing or alleviating the severity of COVID-19 pneumonia, and in preventing pulmonary fibrosis.

27 Jan 2021

Study shows why children of obese mothers have propensity to develop metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.

26 Jan 2021

Astrocytes might be a potential new target to better treat epilepsy

A significant number of epilepsy patients does not respond to currently available drugs. A collaboration between researchers in Japan and at the Heinrich Heine University Düsseldorf now addressed a cell type in the brain that has so far not received much attention in epilepsy therapy.

26 Jan 2021

Study identifies a host of agents with anti-SARS-CoV-2 potential

A team of researchers at the Genomics Research Center, Academia Sinica, in Taiwan, evaluated the efficacy of 2,855 agents against SARS-CoV-2.

22 Jan 2021

Researchers develop ultra-small nanomedicines to target intractable cancers

Ultra-small nanomedicines of approximately 18 nm were fabricated by dynamic ion-pairing between Y-shaped block copolymers and nucleic acid drugs, such as siRNA and antisense drugs.

19 Jan 2021

RECoVERY: New open-source software developed for analyzing SARS-CoV-2 genomes

Researchers report an open-source platform-independent tool for building SARS-CoV-2 genomes from raw sequencing reads. The tool can be used without any extra hardware or software and be run using any browser from a desktop or mobile.

19 Jan 2021

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Jan 2021

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals.

17 Jan 2021

Avalanching nanoparticles may advance real-time bioimaging of cell's organelles and proteins

Since the earliest microscopes, scientists have been on a quest to build instruments with finer and finer resolution to image a cell's proteins - the tiny machines that keep cells, and us, running.

14 Jan 2021

UH researcher working to identify potential new therapeutic targets for kidney disease

Among the primary forms of kidney disease, focal segmental glomerulosclerosis (FSGS) is the most common and is marked by high circulating levels of the suPAR protein (soluble urokinase-type plasminogen activator receptor).

13 Jan 2021

MSU researchers show how microbes could soak up toxic pollutants

When Michigan State University's Gemma Reguera first proposed her new research project to the National Science Foundation, one grant reviewer responded that the idea was not "environmentally relevant."

8 Jan 2021

Bruker and Evosep announce major progress in unbiased, quantitative true single-cell proteomics

Bruker Corporation and Evosep today announced major progress in high-sensitivity, quantitative true single-cell proteomics, using a modified timsTOF Pro mass spectrometer connected to an Evosep One low-flow chromatography system.

From Bruker Daltonics 8 Jan 2021

Novel imaging method reveals in vivo localization of antibiotics in infected lung tissues

Researchers at the Francis Crick Institute and the University of Western Australia have developed a new imaging method to see where antibiotics have reached bacteria within tissues.

5 Jan 2021

Researchers develop new drug discovery method targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

28 Dec 2020

Study shows how sodium ions drive glutamate transport in the central nervous system

Scientists from the MIPT Research Center for Molecular Mechanisms of Aging and Age-Related Diseases have joined forces with their colleagues from Forschungszentrum Jülich, Germany, and uncovered how sodium ions drive glutamate transport in the central nervous system.

22 Dec 2020

Researchers explore why seizures happen in a subset of MS patients

A research team at the University of California, Riverside School of Medicine has identified a pathway involving astrocytes, a class of central nervous system support cells, that could shed light on why seizures happen in a subset of multiple sclerosis, or MS, patients.

21 Dec 2020

Antifungal drug improves key biomarkers in the noses of patients with cystic fibrosis

A drug widely used to treat fungal infections improved key biomarkers in lung tissue cultures as well as in the noses of patients with cystic fibrosis, a clinical study by researchers at the University of Illinois Urbana-Champaign and the University of Iowa found.

17 Dec 2020

Copper gluconate supplementation could reduce SARS-CoV-2 infection in vitro

The second wave of COVID-19 has affected many countries, costing thousands of lives and dealing further heavy blows to already reeling economies.

16 Dec 2020

Researchers design new chemical tool with high configurational stability, catalytic activity

Researchers have designed and built a new chemical tool inspired by natural metal-containing enzymes in living organisms. The product, a tetrahedral "chiral zinc", maintains its shape for years, providing a new structure with exciting possibilities for manufacturing pharmaceuticals and optical electronics.

15 Dec 2020

Novel MRI contrast agent shows strong potential as safer alternative to current products

Adding a contrast-enhancing agent to magnetic resonance imaging (MRI) significantly improves image quality and allows radiologists who interpret MRI scans to pick up subtle anatomic details and abnormalities that might otherwise be missed.