Mammalian Cells News and Research

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Potential novel class of drugs for treating heart attacks and stroke

A new compound that blocks an early step in cell death could lead to a novel class of drugs for treating heart attacks and stroke.

28 Feb 2008

New large-scale method reveals drug targets

Wellcome Trust Sanger Institute scientists have developed a new large-scale method to identify the interactions between proteins that are a major target for therapeutic intervention.

26 Feb 2008

Moss protein plays role in Alzheimer's disease

Preventing Alzheimer's from developing is a goal of Raphael Kopan, Ph.D., professor of molecular biology and pharmacology at the Washington University School of Medicine.

11 Feb 2008

Protein that controls hair growth also keeps stem cells slumbering

Like fine china and crystal, which tend to be used sparingly, stem cells divide infrequently.

25 Jan 2008

Cell division studies hint at future cancer therapy

When a cell's assets get divided between daughter cells, Dr. Quansheng Du wants to make sure both offspring do well.

23 Jan 2008

New method to transfer DNA into a host cell

Genetically engineered products have become indispensable. For example, genetically modified bacteria produce human insulin.

21 Jan 2008

Cancer stem cell marker also drives transcription in normal cells

New research links the recently discovered function of a multi-faceted transcriptional complex to control of gene expression in both normal cells and cancer stem cells.

18 Jan 2008

Viroporins, membrane-permeabilizing proteins of the poliomyelitis virus

A research team from the Universidad Autonoma de Madrid directed by Professor Luís Carrasco has published new discoveries concerning the membrane permeabilizing proteins of the polio virus.

16 Jan 2008

Blocking parasites' communication reduces infection

One of the most common human parasites, Toxoplasma gondii, uses a hormone lifted from the plant world to decide when to increase its numbers and when to remain dormant, researchers at Washington University School of Medicine in St. Louis have found.

10 Jan 2008

New understanding of cell's inner workings

A group of scientists in Princeton's Department of Ecology and Evolutionary Biology has uncovered a new biological mechanism that could provide a clearer window into a cell's inner workings.

7 Jan 2008

Pathogens use previously undescribed mechanism to sabotage host immune system

New research identifies a previously unknown enzymatic mechanism that subverts the early host immune response and promotes pathogenicity by manipulating a common signaling pathway in host cells.

10 Dec 2007

Researchers outline structure of largest nonvirus particle ever crystallized

Researchers at UCLA's California NanoSystems Institute, the David Geffen School of Medicine at UCLA and the Howard Hughes Medical Institute have modeled the structure of the largest cellular particle ever crystallized, suggesting ways to engineer the particles for drug delivery.

27 Nov 2007

There is a new twist on the question of how biological clocks work

In recent years, scientists have discovered that biological clocks help organize a dizzying array of biochemical processes in the body. Despite a number of hypotheses, exactly how the microscopic pacemakers in every cell in the body exert such a widespread influence has remained a mystery.

21 Nov 2007

Morphotek issued new U.S patent for method to enhance the affinity of monoclonal antibodies

Morphotek, Inc., a subsidiary of Eisai Co., Ltd. has announced the issuance of United States Patent No. 7,235,643 B2 (the "643" patent).

19 Nov 2007

Gene-transfer technique trial for childhood blindness under way

Three decades have passed since gene therapy pioneer William W. Hauswirth, Ph.D., and his colleagues at the University of Florida began work on a virus that could safely deliver corrective genes into living animals.

19 Nov 2007

Viral infection affects important cells' stress response

Viral infection disrupts the normal response of mammalian cells to outside deleterious forces, cleaving and inactivating a protein called G3BP that helps drive the formation of stress granules, which shelter the messenger RNAs that carry the code for protein formation, said researchers from Baylor College of Medicine in Houston.

15 Nov 2007

T-cell exhaustion

A new study of immune cells battling a chronic viral infection shows that the cells, called T cells, become exhausted by the fight in specific ways, undergoing profound changes that make them progressively less effective over time.

19 Oct 2007

New mechanism discovered that mammalian cells employ to fight infections of the Hepatitis C virus

A team of researchers led by biologists at the University of California, San Diego has discovered a completely new mechanism that mammalian cells employ to fight infections of the Hepatitis C virus, which affects approximately 2.7 million Americans and 170 million people worldwide.

18 Oct 2007

Enzyme TPPII may contribute to obesity

The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week.

15 Oct 2007

Study reveals the regulatory mechanism of protein kinase A

Research conducted at the University of California, San Diego (UCSD) School of Medicine has shed new light on the structure and function of one of the key proteins in all mammalian cells, protein kinase A (PKA), an enzyme which plays an essential role in memory formation, communication between nerve cells, and cardiac function.

21 Sep 2007