OCT News and Research

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Drug shows striking success in treating children with multi-metastatic Ewing sarcoma

Ewing sarcoma is one of the most common bone cancers seen in children, and if it spreads, it can be deadly. One study found that under a quarter of children with multi-metastatic Ewing sarcoma survived five years after their diagnosis.

23 Oct 2025

Physically fit individuals may better cope with dehydration stress

Individuals who are physically fit may be better equipped to handle the negative effects of dehydration, according to research from the University of California, Riverside. In a study using selectively bred "high-runner" mice, the scientists found that fitter animals increased their voluntary running activity when deprived of water - a finding that could have implications for human performance and health under environmental stress.

23 Oct 2025

How psychedelics profoundly reshape the perception of time and consciousness

A perspective article published in Psychedelics by Prof. Xiaohui Wang and colleagues examines how psychedelic substances profoundly reshape the perception of time, offering unprecedented insights into consciousness and potential therapeutic applications.

23 Oct 2025

New guidelines aid parents and clinicians in pediatric tracheotomy decisions

The emotional strain on parents and other caregivers faced with deciding whether a tracheotomy is the best treatment for their child is hard to measure. The latest clinical practice guideline from the American Thoracic Society aims to give clinicians and parents/caregivers a way forward so they can navigate difficult decisions to ensure better outcomes for young patients. The guideline was published early online today, Wednesday, Oct. 22, in the American Journal of Respiratory and Critical Care Medicine.

23 Oct 2025

Intensive program leads to high type 2 diabetes remission in India

Nearly one-third of people with type 2 diabetes (T2D) in an Indian cohort achieved remission through an intensive lifestyle intervention program, according to a new study publishing October 22, 2025, in the open-access journal PLOS One by Pramod Tripathi of Freedom from Diabetes Clinic & Diabetes Research Foundation, India, and colleagues.

23 Oct 2025

New gene-editing method can correct many disease-causing mutations in mammalian cells

Some genetic disorders-such as cystic fibrosis, hemophilia and Tay Sachs disease-involve many mutations in a person's genome, often with enough variation that even two individuals who share the same disorder might have a different combination of mutations.

23 Oct 2025

Gender disparity in lung transplant access persists despite reforms

New research from UCLA Health reveals that women continue to face barriers in accessing lung transplants compared to men, despite recent national policy changes aimed at making organ distribution more equitable.

23 Oct 2025

Study: Common test to assess viability of IVF embryos may be flawed

A test deployed in many fertility clinics to assess the viability of embryos for use in IVF is likely to overestimate the number of embryos with abnormalities, suggests a study published today.

23 Oct 2025

New type of immunotherapy could change the treatment plan for triple-negative breast cancer

Triple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies.

22 Oct 2025

Hunger and hormones drive aggression in mice

Researchers at the Francis Crick Institute have found that hunger can make virgin female mice aggressive towards pups, but only in certain hormonal states.

22 Oct 2025

New study solves lung transplant rejection mystery

More than 50% of lung-transplant recipients experience a rejection of their new lung within five years of receiving it, yet the reason why this is such a prevalent complication has remained a medical mystery.

22 Oct 2025

Study sheds light on how aging unfolds in pets and humans

Scientists have long sought measurable signs in the body, called biomarkers, that reliably reveal our biological age or predict future health issues.

22 Oct 2025

Foot or ankle injuries in professional football players may increase risk of osteoarthritis

A new paper in Rheumatology, published by Oxford University Press, finds that retired UK male professional football players who reported foot or ankle injuries during their careers were more likely to develop osteoarthritis in retirement.

22 Oct 2025

Understanding the neural mechanisms behind food choices

Feeding in mammals is controlled by a complex neural system. Although several key neural pathways related to total calorie intake have been extensively studied, it is still unclear how food choices are regulated and how they influence overall feeding behavior.

22 Oct 2025

Rare case of pancreatic Hodgkin lymphoma is often misdiagnosed as pancreatic adenocarcinoma

A new case report was published in Volume 12 of Oncoscience on October 6, 2025, titled "A peculiar case of primary lymphoma of pancreas: A rare presentation of Hodgkin lymphoma."

22 Oct 2025

Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

Three copies of chromosome 21 causes Down syndrome (DS), and roughly half of children born each year in the United States with DS-approximately 2,600-also have congenital heart defects (CHDs).

22 Oct 2025

HMGN1 gene linked to heart problems in people with Down syndrome

Nearly half of all babies born with Down syndrome face congenital heart defects, often involving serious malformations that require surgery in the first months of life.

22 Oct 2025

Repeated ketamine infusions offer no extra benefit for people hospitalized with depression

Findings from a randomized and blinded clinical trial investigating repeated ketamine infusions for treating depression have revealed no extra benefit for ketamine when added onto standard care for people admitted to hospital for depression.

22 Oct 2025

Study forces a textbook rewrite on cell division

Scientists at the Ruđer Bošković Institute (RBI) in Zagreb, Croatia, have discovered that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in fact plays a completely different role in chromosome movement.

22 Oct 2025

Analysis highlights the differing physical side effects of antidepressants

Antidepressants can differ widely in how they physically affect the body, including around a 4 kg difference in weight change between certain drugs (approximately 2.5 kg weight loss from agomelatine and 2kg weight gain from maprotiline), confirms a systematic review and meta-analysis published in The Lancet.

22 Oct 2025

OCT News and Research

Drug shows striking success in treating children with multi-metastatic Ewing sarcoma

Physically fit individuals may better cope with dehydration stress

How psychedelics profoundly reshape the perception of time and consciousness

New guidelines aid parents and clinicians in pediatric tracheotomy decisions

Intensive program leads to high type 2 diabetes remission in India

New gene-editing method can correct many disease-causing mutations in mammalian cells

Gender disparity in lung transplant access persists despite reforms

Study: Common test to assess viability of IVF embryos may be flawed

New type of immunotherapy could change the treatment plan for triple-negative breast cancer

Hunger and hormones drive aggression in mice

New study solves lung transplant rejection mystery

Study sheds light on how aging unfolds in pets and humans

Foot or ankle injuries in professional football players may increase risk of osteoarthritis

Understanding the neural mechanisms behind food choices

Rare case of pancreatic Hodgkin lymphoma is often misdiagnosed as pancreatic adenocarcinoma

Nuclear binding protein identified as key contributor to trisomy 21-related CHDs

HMGN1 gene linked to heart problems in people with Down syndrome

Repeated ketamine infusions offer no extra benefit for people hospitalized with depression

Study forces a textbook rewrite on cell division

Analysis highlights the differing physical side effects of antidepressants

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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