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New research sheds light on role of KRAS mutations in pancreatic cancer

Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer.

24 Aug 2023

Stem cell patch for treating macular degeneration to enter phase 2b clinical trial

A stem cell patch developed by USC researchers for patients with macular degeneration will soon be tested in a phase 2b clinical trial.

24 Aug 2023

Women with pre-eclampsia undergo accelerated aging during pregnancy

Pre-eclampsia, a life-threatening surge in blood pressure, is an enigmatic condition. Each year, it causes the deaths of more than 70,000 women worldwide. Because scientists do not know what causes it, they lack targeted strategies to treat it.

24 Aug 2023

New model predicts 10-year risk of dying from breast cancer

A team of researchers at the University of Oxford, led by the Nuffield Department of Primary Care Health Sciences, have developed a new model that reliably predicts a woman's likelihood of developing and then dying of breast cancer within a decade.

24 Aug 2023

KAUST researchers refute challenges to targeted cancer therapy

Drugs that inhibit a key protein should offer new targeted cancer therapy for leukemia and breast cancer.

24 Aug 2023

Lung cells can be trained to counteract inflammation

Inflammation is a standard part of our bodies' immune system response. But sometimes this response becomes hyperactivated in our lungs, causing inflammation to continue unchecked, which can be fatal. Many deaths from COVID-19 have been due to excessive inflammation, which results in acute lung injury.

24 Aug 2023

Urine levels of adenine found to be predictive and causative biomarker of diabetic kidney disease

Urine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported Aug. 24 in the Journal of Clinical Investigation.

24 Aug 2023

Engineered adeno-associated virus vector yields high transduction of the brain vasculature

Researchers have developed an engineered adeno-associated virus (AAV) vector that yields high transduction of brain vascular pericytes and smooth muscle cells.

24 Aug 2023

How have inflammatory bowel disease treatments changed after the introduction of biologics?

Researchers compared changes in inflammatory bowel disease treatment strategies before and after the introduction of biologics in Japan.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Waters launches XBridge Premier GTx BEH SEC columns for gene therapy applications

Waters Corporation introduced the first in a new line of size exclusion chromatography (SEC) columns aimed at improving the analysis while lowering the cost of gene therapies, specifically adeno-associated viral (AAV) vectors.

From Waters Corporation 24 Aug 2023

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

An international phase 3 clinical trial, done in participation with Weill Cornell Medicine and NewYork-Presbyterian, found that a new targeted treatment called zolbetuximab, given in combination with a standard chemotherapy, extended survival for patients with advanced gastric or gastroesophageal junction cancer that overexpressed a specific biomarker.

23 Aug 2023

ME/CFS and Long COVID: A closer look at the similarities and differences

While myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID are not the same disease, they appear to have features of overlapping biological and symptomatic presentations.

23 Aug 2023

CPAP therapy can mitigate telomere shortening in sleep apnea patients

Obstructive sleep apnea (OSA) consists of multiple episodes of partial or complete closure of the upper airway that occur during sleep, leading to breathing cessation lasting more than ten seconds and sometimes even several minutes, followed by arousals and deep breathing.

23 Aug 2023

Therapy News and Research

New research sheds light on role of KRAS mutations in pancreatic cancer

Stem cell patch for treating macular degeneration to enter phase 2b clinical trial

Women with pre-eclampsia undergo accelerated aging during pregnancy

New model predicts 10-year risk of dying from breast cancer

KAUST researchers refute challenges to targeted cancer therapy

Lung cells can be trained to counteract inflammation

Urine levels of adenine found to be predictive and causative biomarker of diabetic kidney disease

Engineered adeno-associated virus vector yields high transduction of the brain vasculature

How have inflammatory bowel disease treatments changed after the introduction of biologics?

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Waters launches XBridge Premier GTx BEH SEC columns for gene therapy applications

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

ME/CFS and Long COVID: A closer look at the similarities and differences

CPAP therapy can mitigate telomere shortening in sleep apnea patients

Plasma treatment to improve osseointegration of dental implants

Study explores lipid and metabolic alterations in HIV/TB co-infected patients

New calculator predicts risk of early recurrence in patients with hepatocellular carcinoma

Scientists find way to 'press self-destruct button' in gastric cancer associated with Epstein-Barr Virus

Aspirin underutilized for preventing heart attack, stroke

NCCN publishes new resource on options, benefits of care approaches for pediatric Hodgkin lymphoma

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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