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Scientists uncover changes in immediate environment of DNA after fertilization

A team of scientists at the Helmholtz Zentrum München shows changes in the immediate environment of DNA after the ovum and sperm fuse to form the zygote. The results suggest why all conceivable somatic cells can develop from the germ cells. The study has been published in the journal 'Genes and Development'.

6 Dec 2016

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Imagine a key that opens a pin tumbler lock. A very similar key can also fit into the lock, but upside down in comparison to the first key.

6 Dec 2016

Study highlights requirement of protein in initiation of apoptosis in uveal melanoma

New research from the University of Liverpool has identified the role of a specific protein in the human body that can help prevent the survival and spread of eye cancer, by initiating cancer 'cell-suicide'.

6 Dec 2016

Gut microbes may play important role in exacerbated post-dieting weight gain

Following a successful diet, many people are dismayed to find their weight rebounding - an all-too-common phenomenon termed "recurrent" or "yo-yo" obesity.

5 Dec 2016

Hemophilia B patients produce near-normal levels of clotting factor IX after gene therapy, study shows

Researchers are reporting the highest and most sustained levels to date of the essential blood-clotting factor IX in patients with the inherited bleeding disorder hemophilia B.

4 Dec 2016

Newcastle scientists develop promising new test to identify patients with rare liver disease

Newcastle scientists and medics have developed a promising new test to identify patients with a rare liver disease who will not respond to standard treatment, allowing earlier intervention with alternatives.

2 Dec 2016

NASPGHAN clinical practice guidelines recommend screening test for NAFLD in obese children

A screening test for non-alcoholic fatty liver disease (NAFLD)--a serious condition that may have lifelong health consequences--is recommended for all obese children aged nine to eleven years, according to clinical practice guidelines developed by the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and published in the Journal of Pediatric Gastroenterology and Nutrition.

1 Dec 2016

How old is your heart?

There have been a number of ways to measure the biological health and age of your heart, which has been done conventionally in the past. Blood pressure is one indicator. Other risk indicators include family history of heart disease, level of cholesterol and exercise testing, where you can get heart rate...

From iHeart - VitalSines International Inc. 1 Dec 2016

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

CRISPR/Cas9, a powerful genome editing tool, is showing promise for efficient correction of disease-causing mutations.

1 Dec 2016

Alcohol consumption linked to higher risk of melanoma

Alcohol intake was associated with higher rates of invasive melanoma among white men and women.

1 Dec 2016

Pasteurised intestinal bacterium could stop progression of obesity and diabetes in mice

The intestinal bacterium Akkermansia proves to offer enduring benefits for the intestines of overweight mice and diabetic animals.

30 Nov 2016

New study finds smoking cessation at any age reduces risk of death

Tobacco use continues to be a major cause of cancer and premature death. Most studies of cigarette smoking and mortality have focused on middle-aged populations, with fewer studies examining the impact of tobacco cessation on disease and mortality risk among the elderly.

30 Nov 2016

Over-the-counter and prescription pain medications linked to drug-induced liver injury

More than 1,000 medications, with acetaminophen being the most common, have been associated with drug-induced liver injury.

30 Nov 2016

New green nanotechnology approach targets, destroys precancerous tumor cells in livers of mice

According to the American Cancer Society, more than 700,000 new cases of liver cancer are diagnosed worldwide each year.

29 Nov 2016

Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Researchers at Indiana University's Biocomplexity Institute have developed a virtual model of the human liver to better understand how the organ metabolizes acetaminophen, a common non-prescription painkiller and fever-reducer used in over-the-counter drugs such as Tylenol.

29 Nov 2016

Enzyme research provides new insights into pathophysiology of depression

Despite the fact that more than four percent of the world's population suffer from depression, and even though approximately 1,500 individuals commit suicide each year in Sweden, the understanding of the pathophysiology of depression remains unclear and only a few new discoveries of mechanisms behind it have been made in recent years.

29 Nov 2016

Researchers develop new way to design glycoclusters for targeted drug delivery

A team led by researchers at the RIKEN Biofunctional Synthetic Chemistry Laboratory in Japan has developed a way to engineer glycan complexes--clusters of sugar chains attached to proteins or lipids--in a way that allows the molecules to be transported preferentially to specific organs of the body, depending on the sugar chains contained in the cluster.

29 Nov 2016

Research provides insight into molecular mechanisms involved in immune response to HBV

The innate immune system in mammals defends against infection from viruses and other microbial infections.

28 Nov 2016

Vitamin D supplements do not prevent disease in the majority, says study

Current evidence does not support that vitamin D supplementation does anything to help prevent disease among the majority of people, according to a new study published in the British Medical Journal (BMJ).

24 Nov 2016

New research provides insights into how gut microbes drive host gene expression

In our guts, and in the guts of all animals, resides a robust ecosystem of microbes known as the microbiome. Consisting of trillions of organisms — bacteria, fungi and viruses — the microbiome is essential for host health, providing important services ranging from nutrient processing to immune system development and maintenance.

23 Nov 2016

Liver News and Research

Scientists uncover changes in immediate environment of DNA after fertilization

Biochemists uncover how potential diabetes drugs interact with LRH-1 protein

Study highlights requirement of protein in initiation of apoptosis in uveal melanoma

Gut microbes may play important role in exacerbated post-dieting weight gain

Hemophilia B patients produce near-normal levels of clotting factor IX after gene therapy, study shows

Newcastle scientists develop promising new test to identify patients with rare liver disease

NASPGHAN clinical practice guidelines recommend screening test for NAFLD in obese children

How old is your heart?

Penn researchers use CRISPR/Cas9 gene targeting approach to treat hemophilia B in mice

Alcohol consumption linked to higher risk of melanoma

Pasteurised intestinal bacterium could stop progression of obesity and diabetes in mice

New study finds smoking cessation at any age reduces risk of death

Over-the-counter and prescription pain medications linked to drug-induced liver injury

New green nanotechnology approach targets, destroys precancerous tumor cells in livers of mice

Researchers develop virtual liver model to better understand metabolism of non-prescription painkiller

Enzyme research provides new insights into pathophysiology of depression

Researchers develop new way to design glycoclusters for targeted drug delivery

Research provides insight into molecular mechanisms involved in immune response to HBV

Vitamin D supplements do not prevent disease in the majority, says study

New research provides insights into how gut microbes drive host gene expression

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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