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Carboplatin and paclitaxel show promise for advanced thymic carcinoma

A multicentre, phase II study of carboplatin and paclitaxel in chemotherapy-naïve patients with advanced thymic carcinoma has shown that the treatment has promising efficacy compared with standard anthracycline-based chemotherapy.

10 Dec 2014

PD-L1 expression tied to favourable prognosis in SCLC

Programmed death-ligand 1 is expressed by around 70% of small-cell lung cancers and is associated with favourable patient outcomes, Japanese researchers report.

10 Dec 2014

Heat-shock protein 90 enables ER+ breast cancers to develop resistance to hormonal therapy

Long known for its ability to help organisms successfully adapt to environmentally stressful conditions, the highly conserved molecular chaperone heat-shock protein 90 (HSP90) also enables estrogen receptor-positive (ER+) breast cancers to develop resistance to hormonal therapy.

10 Dec 2014

Cigarette smoking continues to cause nearly three in ten cancer deaths in the U.S.

A new American Cancer Society study finds that despite significant drops in smoking rates, cigarettes continue to cause about three in ten cancer deaths in the United States. The study, appearing in the Annals of Epidemiology, concludes that efforts to reduce smoking prevalence as rapidly as possible should be a top priority for the U.S. public health efforts to prevent cancer deaths.

10 Dec 2014

Advances in fight against TB, sudden cardiac death

Research projects into two of the biggest killers in worldwide health, tuberculosis and sudden cardiac death, will be the subjects of the University of Leicester Graduate School Doctoral Inaugural Lectures, delivered by two of the winners of this year's PhD prizes in the College of Medicine, Biological Sciences and Engineering.

10 Dec 2014

Drug proves effective at inhibiting growth of drug-resistant bacteria

A treatment pioneered at the University of Pittsburgh Center for Vaccine Research is far more effective than traditional antibiotics at inhibiting the growth of drug-resistant bacteria, including so-called "superbugs" resistant to almost all existing antibiotics, which plague hospitals and nursing homes.

10 Dec 2014

PAH markers identified among Chinese systemic sclerosis patients

A study of Chinese patients with systemic sclerosis has identified predictive markers for accompanying pulmonary arterial hypertension similar to those that have been identified in other ethnic groups.

9 Dec 2014

PD-1, PD-L1 differentially expressed in NSCLC

The expression of the immune checkpoint protein programmed death-1 receptor and its ligand varies according to tumour and patient characteristics in oncogene-addicted non-small-cell lung cancer, research indicates.

9 Dec 2014

Cardiac monitoring foretells clinical deterioration in PAH

Monitoring right ventricular parameters can give advance warning of clinical deterioration in stable patients with idiopathic pulmonary arterial hypertension, research suggests.

9 Dec 2014

Infant mortality rates for RSV much lower than previously thought

It's a virus that has long been characterized as dangerous and even deadly, but new research shows infant deaths from respiratory syncytial virus (RSV) are actually quite uncommon in the 21st century.

9 Dec 2014

Agent THZ1 shrinks human-like small cell lung tumors in mice

Small cell lung cancer - a disease for which no new drugs have been approved for many years - has shown itself vulnerable to an agent that disables part of tumor cells' basic survival machinery, researchers at Dana-Farber Cancer Institute and the Massachusetts Institute of Technology reported.

9 Dec 2014

Experts launch new interdisciplinary scientific collaboration to improve health in urban areas

Aiming to empower planners and policy-makers to achieve better health for billions of people living in fast-growing urban areas, world health, environmental, behavioural and social science experts today launched a major new interdisciplinary scientific collaboration.

9 Dec 2014

Studies presented at ASH meeting compare new, standard-of-care treatments for blood clots

Studies presented at the 56th American Society of Hematology Annual Meeting and Exposition compare new and standard-of-care treatments for blood clots and further illuminate clot risks in vulnerable populations, such as cancer patients.

8 Dec 2014

Researchers report promising outcomes from clinical trial in patients with dyskeratosis congenita

Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center report promising outcomes from a clinical trial with patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only. This is the first trial reporting successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand.

8 Dec 2014

Nivolumab drug highly effective for Hodgkin's lymphoma

A phase I clinical trial of nivolumab found that the immune-boosting drug is a highly effective therapy for Hodgkin's lymphoma. The multi-institution study, led by Mayo Clinic, indicated that the drug was safe and led to an 87 percent response rate in patients who had failed on other treatments.

7 Dec 2014

Study shows link between cardiac abnormalities, sudden unexpected death in epilepsy

Groundbreaking findings describing the link between cardiac abnormalities and sudden unexpected death in epilepsy (SUDEP) will be presented at the American Epilepsy Society's Annual Meeting in December.

7 Dec 2014

Two medical imaging techniques could predict effectiveness of TB drugs

Two medical imaging techniques, called positron emission tomography (PET) and computed tomography (CT), could be used in combination as a biomarker to predict the effectiveness of antibiotic drug regimens being tested to treat tuberculosis (TB) patients, according to researchers at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

5 Dec 2014

TSRI scientists identify 'mechanoreceptor' protein that mediates sense of touch in mammals

A team led by biologists at The Scripps Research Institute has solved a long-standing mystery in neuroscience by identifying the "mechanoreceptor" protein that mediates the sense of touch in mammals.

5 Dec 2014

Study: PET scanning strategy could help predict effectiveness of TB drugs

Sophisticated lung imaging can show whether or not a treatment drug is able to clear tuberculosis (TB) lung infection in human and macaque studies, according to researchers at the University of Pittsburgh School of Medicine and their international collaborators.

5 Dec 2014

DePuy Synthes Spine receives FDA clearance to market VEPTR/VETPR II Devices for TIS treatment

DePuy Synthes Spine today announced it has received 510(k) clearance from the U.S. Food and Drug Administration to market the VEPTR/VEPTR II Vertical Expandable Prosthetic Titanium Rib Devices for the treatment of Thoracic Insufficiency Syndrome (TIS), a rare congenital condition where severe deformities of the chest, spine or ribs impair breathing and lung growth in children.

5 Dec 2014

Lungs News and Research

Carboplatin and paclitaxel show promise for advanced thymic carcinoma

PD-L1 expression tied to favourable prognosis in SCLC

Heat-shock protein 90 enables ER+ breast cancers to develop resistance to hormonal therapy

Cigarette smoking continues to cause nearly three in ten cancer deaths in the U.S.

Advances in fight against TB, sudden cardiac death

Drug proves effective at inhibiting growth of drug-resistant bacteria

PAH markers identified among Chinese systemic sclerosis patients

PD-1, PD-L1 differentially expressed in NSCLC

Cardiac monitoring foretells clinical deterioration in PAH

Infant mortality rates for RSV much lower than previously thought

Agent THZ1 shrinks human-like small cell lung tumors in mice

Experts launch new interdisciplinary scientific collaboration to improve health in urban areas

Studies presented at ASH meeting compare new, standard-of-care treatments for blood clots

Researchers report promising outcomes from clinical trial in patients with dyskeratosis congenita

Nivolumab drug highly effective for Hodgkin's lymphoma

Study shows link between cardiac abnormalities, sudden unexpected death in epilepsy

Two medical imaging techniques could predict effectiveness of TB drugs

TSRI scientists identify 'mechanoreceptor' protein that mediates sense of touch in mammals

Study: PET scanning strategy could help predict effectiveness of TB drugs

DePuy Synthes Spine receives FDA clearance to market VEPTR/VETPR II Devices for TIS treatment

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