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Study explores artemisinin resistance in Plasmodium falciparum malaria

According to the World Health Organization's 2014 World Malaria Report, there are an estimated 198 million cases of malaria worldwide with 3.3 billion people at risk for contracting the infection. Although the impact of malaria is still significant, the statistics reflect a considerable reduction in the global malaria burden. Since 2010, disease transmission has been reduced by 30 percent and mortality due to malaria has decreased by almost half.

21 Apr 2015

Medical University of Vienna study supports use of ANGLE's Parsortix system for ovarian cancer study

ANGLE plc, the specialist medtech company, is delighted to announce that the Medical University of Vienna, one of its key opinion leaders, has published highly encouraging results in support of the use of ANGLE's Parsortix system in the detection of ovarian cancer.

21 Apr 2015

TERT gene alterations co-occur with frequently altered bladder cancer genes

In results presented today at the American Association for Cancer Research Annual Meeting 2015, a collaborative study by the University of Colorado Cancer Center and the National Cancer Institute reports that the TERT gene promoter was altered in 69 percent of 54 cases of bladder cancer due to variants that occur after birth (called "somatic") and in 56 percent of bladder cancers due to inherited variants (called "germline").

21 Apr 2015

New study sheds light on mechanism that affects AID enzyme

A new study by immunology researchers at the IRCM led by Javier M. Di Noia, PhD, sheds light on a mechanism affecting AID, a crucial enzyme for the immune response. The scientific breakthrough, published in the latest issue of The Journal of Experimental Medicine, could eventually improve the way we treat the common flu, as well as lymphoma and leukemia.

21 Apr 2015

Joseph Roche receives grant to develop improved exercise programs for people with dysferlinopathies

The Wayne State University Eugene Applebaum College of Pharmacy and Health Sciences today announced that Joseph Roche, assistant professor for the physical therapy program in the Department of Health Care Sciences, received a one-year, $100,000 grant from the Jain Foundation for "Developing a Multi-Pronged Strategy for the Clinical Management of Dysferlinopathies," a project that seeks to develop better exercise programs for people with dysferlinopathies, or dysferlin-linked muscular dystrophies.

21 Apr 2015

Latest genome sequencing techniques help identify new autoimmune syndrome in children

Using the latest genome sequencing techniques, a research team led by scientists from UC San Francisco, Baylor College of Medicine, and Texas Children's Hospital has identified a new autoimmune syndrome characterized by a combination of severe lung disease and arthritis that currently has no therapy.

21 Apr 2015

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

Early data in a preliminary human study show that an experimental immune system drug is generally safe and well tolerated in women with metastatic, triple-negative breast cancer, a persistently difficult form of the disease to treat.

21 Apr 2015

CML guidelines highlight need for TKI switch timing, choice

A review of the European LeukemiaNet guidelines on the care of patients with chronic myeloid leukaemia highlights the need for research into the timing and use of second-line and third-line tyrosine kinase inhibitors.

20 Apr 2015

Novel treatment strategy targets treatment-resistant CML

Researchers have shown that the coiled-coil mimetic CCmut3 can inhibit cell growth and promote apoptosis in cell lines expressing BCR–ABL1, including those resistant to tyrosine kinase inhibitors.

20 Apr 2015

University of Washington receives PPMD grant to continue analysis of spectrin-like repeats in dystrophin

Parent Project Muscular Dystrophy, a nonprofit organization leading the fight to end Duchenne muscular dystrophy (Duchenne) awarded University of Washington a $148,000 grant to continue the functional analysis of spectrin-like repeats in dystrophin.

20 Apr 2015

MD Anderson researchers identify key factor that may explain drug resistance in glioblastoma

Researchers at the NFCR Center for Cancer System Informatics at MD Anderson Cancer Center have discovered a key factor that may explain drug resistance in glioblastoma (GBM), the most common and deadliest form of brain cancer.

20 Apr 2015

Scientists reveal three major subsets of KRAS-mutant LUAC

Mutations of the KRAS gene are commonly known to lead to cancer. However, deeper understanding of exactly how they do this continues to be explored by cancer researchers.

20 Apr 2015

Paradigm to provide PCDx test to oncologists in TD2 networks

Paradigm and Translational Drug Development today announced a partnership under which Paradigm will provide their PCDx test to TD2's affiliated oncology provider networks.

20 Apr 2015

RetroSense Therapeutics receives Luis Villalobos Award

RetroSense Therapeutics, LLC, a Wayne State University start-up biotechnology company, has received the Luis Villalobos Award from the Angel Capital Association, the world's leading professional association for angel investors.

20 Apr 2015

Malaria parasites with Ap2mu gene mutation less sensitive to antimalarial drug artemisinin

Early indicators of the malaria parasite in Africa developing resistance to the most effective drug available have been confirmed, according to new research published in Antimicrobial Agents and Chemotherapy.

20 Apr 2015

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

Almost one in four patients (24%) with advanced lung cancer in Europe, Asia and the US are not receiving EGFR test results before being started on treatment, researchers report at the European Lung Cancer Conference.

20 Apr 2015

Some lung cancer patients can benefit from melanoma drugs

A subset of lung cancer patients can derive important clinical benefits from drugs that are more commonly used to treat melanoma, the authors of a new academic clinical trial in Europe have reported at the European Lung Cancer Conference (ELCC) in Geneva, Switzerland.

20 Apr 2015

Scientists discover protein that boosts immunity to viruses and cancer

Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses...

17 Apr 2015

Groundbreaking study looks at how puberty affects voice changes in male singers

The first round of tests have been completed for members of the Cincinnati Boychoir who are part of a joint study with Cincinnati Children's Hospital Medical Center to look at the changing voices of male singers.

17 Apr 2015

Study could lead to new therapeutic targets for treating Huntington's disease

An international study led by researchers from Université Laval and CHU de Québec-Université Laval has identified significant vascular changes in the brains of people with Huntington's disease. This breakthrough, the details of which are published in the most recent issue of Annals of Neurology, will have significant implications for our understanding of the disease and could open the door to new therapeutic targets for treating this fatal neurodegenerative condition.

17 Apr 2015

Mutation News and Research

Study explores artemisinin resistance in Plasmodium falciparum malaria

Medical University of Vienna study supports use of ANGLE's Parsortix system for ovarian cancer study

TERT gene alterations co-occur with frequently altered bladder cancer genes

New study sheds light on mechanism that affects AID enzyme

Joseph Roche receives grant to develop improved exercise programs for people with dysferlinopathies

Latest genome sequencing techniques help identify new autoimmune syndrome in children

Experimental immune therapy generally safe, well-tolerated in women with triple-negative breast cancer

CML guidelines highlight need for TKI switch timing, choice

Novel treatment strategy targets treatment-resistant CML

University of Washington receives PPMD grant to continue analysis of spectrin-like repeats in dystrophin

MD Anderson researchers identify key factor that may explain drug resistance in glioblastoma

Scientists reveal three major subsets of KRAS-mutant LUAC

Paradigm to provide PCDx test to oncologists in TD2 networks

RetroSense Therapeutics receives Luis Villalobos Award

Malaria parasites with Ap2mu gene mutation less sensitive to antimalarial drug artemisinin

Study: 1 in 4 patients with advanced lung cancer does not receive EGFR test results before treatment

Some lung cancer patients can benefit from melanoma drugs

Scientists discover protein that boosts immunity to viruses and cancer

Groundbreaking study looks at how puberty affects voice changes in male singers

Study could lead to new therapeutic targets for treating Huntington's disease

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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