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Study suggests genetic component in pain response among children

At least two common gene variants are linked to "clinically meaningful" differences in pain scores in children after major surgery, reports a study in the January issue of Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

25 Dec 2012

Elevated C-reactive protein linked to psychological distress and depression

Elevated levels of C-reactive protein, a marker of inflammatory disease, appear to be associated with increased risk of psychological distress and depression in the general population of adults in Denmark, according to a report published Online First by Archives of General Psychiatry, a JAMA Network publication.

25 Dec 2012

Cellular metabolism of immune cells protect against viral infections and tumours

New research demonstrates that the cellular metabolism of certain immune cells is closely linked to their function, which includes protecting against viral infections and the development of tumours.

25 Dec 2012

TNF inhibitor efficacy may depend on brain activity

How well a patient responds to tumor necrosis factor inhibitor therapy may depend on brain activity reflecting the individual’s perception of their rheumatoid arthritis, scientists believe.

24 Dec 2012

Bipolar subtypes have differing personality traits

Results from a Korean study show how personality trait patterns differ between patients with bipolar I and II disorder.

22 Dec 2012

Researchers demonstrate significance of two proteins in nerve cell development

The study conducted by Prof. Frank Bradke's team provides indications on brain development and about the causes of diseases of the nervous system. The results have now been published in "Neuron".

21 Dec 2012

Autism genome not shy about tinkering with important genes

An international team, led by researchers from the University of California, San Diego School of Medicine, has discovered that "random" mutations in the genome are not quite so random after all. Their study, to be published in the journal Cell on December 21, shows that the DNA sequence in some regions of the human genome is quite volatile and can mutate ten times more frequently than the rest of the genome. Genes that are linked to autism and a variety of other disorders have a particularly strong tendency to mutate.

21 Dec 2012

PEPFAR scale-up linked to strengthening of health systems, study says

Noting "PEPFAR has been criticized for its vertical or 'stove-piping' structure, with resources targeting a specific disease rather than working to strengthen the underlying health system," a study published in the Journal of Acquired Immune Deficiency Syndromes "aimed to evaluate whether PEPFAR activities were associated with system-wide improvements in both proximal and distal indicators of health systems strengthening."

21 Dec 2012

Research Roundup: Health law's under-26 coverage 'significantly increased' access to care; Thousands of surgical 'never events' occur each year

The health law allows young adults to remain under their parents' health insurance plans until age 26, raising questions about the law's overall impact on access to care. Researchers used data from two nationally representative surveys to compare young adults who've gained access to dependent coverage to a control group of individuals (ages 26-34) unaffected by the new policy.

21 Dec 2012

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

A researcher with the Faculty of Medicine & Dentistry and the Mazankowski Alberta Heart Institute is looking closely at a molecule linked to aortic aneurysms in the abdomen, and her findings could lead to a treatment to reduce swelling of the aortic artery, which would be a life-saving treatment.

21 Dec 2012

FDA seeks input from states on drug compounders

FDA Commissioner Margaret Hamburg convened a meeting that included federal officials and representatives from state boards of pharmacy and governors' offices. Meanwhile, the Los Angeles Times reports on "rogue pharmacists."

21 Dec 2012

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

My mortality wake-up call came in a hospital after knee surgery, when I flat-lined because of a heart arrhythmia and was resuscitated by a nurse. In response to columns about those events, stories have streamed in from people who are running out of time themselves, or enduring the pain of watching loved ones fade. The deaths they face are as different as the lives they've lived, but a steady refrain runs through their emails and letters.

21 Dec 2012

Proteins detected in urine may enable diagnosis of Kawasaki disease

A set of proteins detected in urine by researchers at Boston Children's Hospital may prove to be the first biomarkers for Kawasaki disease, an uncommon but increasingly prevalent disease which causes inflammation of blood vessels that can lead to enlarged coronary arteries and even heart attacks in some children.

20 Dec 2012

Cannabis use linked to poorer cognition in dependent schizophrenia patients

Cumulative cannabis use is negatively associated with cognition in men with schizophrenia who are currently dependent on the drug, report researchers.

20 Dec 2012

Antibiotic amoxicillin ineffective for treating cough according to European trial

The antibiotic amoxicillin, that doctors typically prescribe for common lower respiratory tract infections (LRTI) such as cough and bronchitis, is no more effective at relieving symptoms than the use of no medication, even in older patients. The findings from the largest randomised placebo controlled trial of antibiotics for acute uncomplicated LRTI to date are published Online First in The Lancet Infectious Diseases.

20 Dec 2012

V-chip could allow health care providers to do 50 different tests in one go

A new device about the size of a business card could allow health care providers to test for insulin and other blood proteins, cholesterol, and even signs of viral or bacterial infection all at the same time—with one drop of blood. Preliminary tests of the V-chip, created by scientists at The Methodist Hospital Research Institute and MD Anderson Cancer Center, were published last night by Nature Communications.

20 Dec 2012

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Neuroscientists at Georgetown University Medical Center say they have new evidence that challenges scientific dogma involving two fatal neurodegenerative diseases - amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD) - and, in the process, have uncovered a possible therapeutic target as a novel strategy to treat both disorders.

20 Dec 2012

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

By all accounts, a combination of colon cancer, diabetes and high blood pressure can be a recipe for medical disaster. Now, a new study led by a surgical oncologist and researcher at Temple University School of Medicine and Fox Chase Cancer Center has shown just how deadly this mix can be.

20 Dec 2012

Lou Gehrig's disease may be treatable using neural stem cells

Promising new research provides evidence that ALS, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be treatable using neural stem cells.

20 Dec 2012

Genomic technology revolutionizes gene discovery and disease understanding in autism

Genomic technology has revolutionized gene discovery and disease understanding in autism, according to an article published in the December 20 issue of the journal Neuron.

20 Dec 2012

X linked News and Research

Study suggests genetic component in pain response among children

Elevated C-reactive protein linked to psychological distress and depression

Cellular metabolism of immune cells protect against viral infections and tumours

TNF inhibitor efficacy may depend on brain activity

Bipolar subtypes have differing personality traits

Researchers demonstrate significance of two proteins in nerve cell development

Autism genome not shy about tinkering with important genes

PEPFAR scale-up linked to strengthening of health systems, study says

Research Roundup: Health law's under-26 coverage 'significantly increased' access to care; Thousands of surgical 'never events' occur each year

Researcher looks at role of TIMP3 protein linked with aortic aneurysms in the abdomen

FDA seeks input from states on drug compounders

Longer looks: Disparities in nursing home penalties; Understanding dying with dignity

Proteins detected in urine may enable diagnosis of Kawasaki disease

Cannabis use linked to poorer cognition in dependent schizophrenia patients

Antibiotic amoxicillin ineffective for treating cough according to European trial

V-chip could allow health care providers to do 50 different tests in one go

Scientists uncover TDP-43 protein as possible target for treatment of ALS, FTD

Patients with hypertension or diabetes have increased risk of cancer recurrence, survival

Lou Gehrig's disease may be treatable using neural stem cells

Genomic technology revolutionizes gene discovery and disease understanding in autism

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