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Ibrutinib outperforms ofatumumab as second-line therapy for CLL treatment

In a head-to-head comparison of two Food and Drug Administration-approved drugs for the treatment of relapsed chronic lymphocytic leukemia (CLL), ibrutinib significantly outperformed ofatumumab as a second-line therapy, according to a multicenter interim study published in the OnLine First edition of the New England Journal of Medicine.

2 Jun 2014

Findings could lead to treatments for blood disorders associated with iron deficiencies and overloads

A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production.

2 Jun 2014

Promedior reports positive preliminary data from PRM-151 Phase 2 trial for myelofibrosis

Promedior, Inc., today announced positive preliminary data from its Phase 2 trial of PRM-151, an anti-fibrotic immunotherapy, in patients with myelofibrosis which demonstrated biologic activity with improvements across clinically relevant measures, including bone marrow fibrosis, hemoglobin, platelets, spleen, and symptoms.

31 May 2014

Women with metastatic breast cancer can receive bisphosphonates less frequently and safely

Women with metastatic breast cancer to the bone may be able to receive bisphosphonates, the bone-targeting class of drugs like zoledronic acid, less often after the first year of monthly administration.

31 May 2014

New approach provides a viable way to culture hESCs for clinical purposes

To be suitable for medical transplantation, one idea is that human embryonic stem cells (hESCs) need to remain "undifferentiated" i.e. they are not changing into other cell types.

29 May 2014

Noninvasive laser therapy triggers stem cells to repair enamel of teeth

A Harvard-led team is the first to demonstrate the ability to use low-power light to trigger stem cells inside the body to regenerate tissue, an advance they reported in Science Translational Medicine.

29 May 2014

NASA evalutes force shoe technology

Maintaining astronaut bone and muscle health in microgravity is an ongoing concern for NASA, and now the agency is "forcing" the issue with a new investigation.

29 May 2014

Patrys reports positive results from PAT-SM6 clinical trial in patients with multiple myeloma

Patrys Limited, a clinical stage biotechnology company, is pleased to announce the clinical results from a patient treated with PAT-SM6 in combination with other marketed multiple myeloma drugs.

28 May 2014

Study detects hormone receptor's key role in normal organ development and function

A discovery by UC Irvine endocrinologists about the importance of cell surface receptors for estrogen has the potential to change how researchers view the hormone's role in normal organ development and function.

28 May 2014

Scientists find interplay between two specific proteins crucial for flawless repair of crosslink damage

Environmental influences such as ionizing radiation, intense heat or various chemical substances damage the DNA constantly.

27 May 2014

Abiogen Pharma, Lee's Pharma sign deal to market Neridronic Acid

Abiogen Pharma S.p.A. of Pisa Italy and Lee's Pharm jointly announced the agreement for License, Distribution and Supply for marketing of Attila® (Neridronic Acid) throughout China, Hong Kong, Macau and Taiwan.

27 May 2014

McGill researchers show melatonin supplements may make bones stronger in old rats

McGill researchers have shown that melatonin supplements may make bones stronger in old rats. This suggests a possible avenue for the prevention of osteoporosis.

27 May 2014

Peptide antibodies hit immune-response-stifling MDSCs without harming other vital cells

Scientists have found a way to target elusive cells that suppress immune response, depleting them with peptides that spare other important cells and shrink tumors in preclinical experiments, according to a paper published online by Nature Medicine.

26 May 2014

SinoVeda announces positive clinical results for EffectiCal in post-menopausal women

SinoVeda Canada Inc. today announces positive clinical results for EffectiCal® from its 24-week double-blind, randomized comparative clinical trial in post-menopausal women.

22 May 2014

Managing menopausal symptoms in work life extremely difficult for working women

A new national survey released today by Working Mother Media and Pfizer on the impact of menopausal symptoms on women in the workplace finds that managing menopausal symptoms in their work life is extremely or somewhat difficult for nearly half (48 percent) of working women ages 45-65 who have experienced these symptoms in the past year.

21 May 2014

New drug offers promising possibility for treating adults with periodontitis

Nearly half of all adults in the United States suffer from the gum disease periodontitis, and 8.5 percent have a severe form that can raise the risk of heart disease, diabetes, arthritis and pregnancy complications.

21 May 2014

BioLineRx announces financial results for Q1 2014, provides operational update

BioLineRx, a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, today reported its financial results for first quarter ended March 31, 2014.

20 May 2014

Elotuzumab granted Breakthrough Therapy Designation for treatment of multiple myeloma

Bristol-Myers Squibb Company and AbbVie today announced that the U.S. Food and Drug Administration (FDA) has granted elotuzumab, an investigational humanized monoclonal antibody, Breakthrough Therapy Designation for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma in patients who have received one or more prior therapies.

20 May 2014

Implantable system improves sleep and heart function without mask

A novel device implanted under the skin like a pacemaker successfully treats central sleep apnoea (CSA) in heart failure patients, according to research presented today at the Heart Failure Congress 2014, held 17-20 May in Athens, Greece.

19 May 2014

Study examines predictors and effects of testosterone therapy

Three new studies examining the predictors, effects and durability of testosterone therapy on men will be presented to reporters at the 109th Annual Scientific Meeting of the American Urological Association (AUA) during a special press conference in the Orange County Convention Center, Orlando, FL on Sunday, May 18 at 2:00 p.m. ET.

19 May 2014

Bone News and Research

Ibrutinib outperforms ofatumumab as second-line therapy for CLL treatment

Findings could lead to treatments for blood disorders associated with iron deficiencies and overloads

Promedior reports positive preliminary data from PRM-151 Phase 2 trial for myelofibrosis

Women with metastatic breast cancer can receive bisphosphonates less frequently and safely

New approach provides a viable way to culture hESCs for clinical purposes

Noninvasive laser therapy triggers stem cells to repair enamel of teeth

NASA evalutes force shoe technology

Patrys reports positive results from PAT-SM6 clinical trial in patients with multiple myeloma

Study detects hormone receptor's key role in normal organ development and function

Scientists find interplay between two specific proteins crucial for flawless repair of crosslink damage

Abiogen Pharma, Lee's Pharma sign deal to market Neridronic Acid

McGill researchers show melatonin supplements may make bones stronger in old rats

Peptide antibodies hit immune-response-stifling MDSCs without harming other vital cells

SinoVeda announces positive clinical results for EffectiCal in post-menopausal women

Managing menopausal symptoms in work life extremely difficult for working women

New drug offers promising possibility for treating adults with periodontitis

BioLineRx announces financial results for Q1 2014, provides operational update

Elotuzumab granted Breakthrough Therapy Designation for treatment of multiple myeloma

Implantable system improves sleep and heart function without mask

Study examines predictors and effects of testosterone therapy

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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