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Low vitamin D may affect recovery of injured corneas

Injury or disease in combination with too little vitamin D can be bad for the window to your eyes. The three-layer, transparent cornea at the front of the eyes focuses the light coming in. But its prominent position also puts it at risk for injury from an errant mascara wand or over-prodding finger or a car accident.

24 Jul 2017

Novel model predicts single heart cell's response to dwindling supplies of oxygen

Time is of the essence when treating a patient undergoing a heart attack. Cardiac surgeons attempt to quickly stabilize the heart by applying reperfusion, a technique that restores oxygen to the heart by opening up blocked vessels with balloons and stents.

21 Jul 2017

Study identifies new mutations linked to hereditary neuroendocrine tumors

Pheochromocytomas and paragangliomas are rare neuroendocrine tumors with a strong hereditary component. Half the genes whose alterations confer hereditary susceptibility to develop this condition code for enzymes involved in the Krebs cycle, a metabolic route involved in cellular respiration.

20 Jul 2017

Researchers find new way to protect stem cells from inflammation during wound repair

Scientists have found a new way to protect stem cells from harsh inflammation during wound repair. In a study recently published in the journal Cytotherapy, researchers in India discovered that treating mice with a common anti-inflammatory drug called celecoxib promoted stem cell survival and healing when they injected the cells into wounds.

20 Jul 2017

Genetic therapy for two inherited neurologic diseases moves closer to human clinical trials

Researchers at University of Massachusetts Medical School and Auburn University College of Veterinary Medicine are nearing human clinical trials on a genetic therapy for two rare neurological diseases that are fatal to children.

19 Jul 2017

Aggressive treatment for hypertension may lead to kidney damage, research suggests

Aggressive combination treatments for high blood pressure that are intended to protect the kidneys may actually be damaging the organs, new research from the University of Virginia School of Medicine suggests.

18 Jul 2017

Study provides insights into intergenerational inheritance of epigenetic information

We are more than the sum of our genes. Epigenetic mechanisms modulated by environmental cues such as diet, disease or our lifestyle take a major role in regulating the DNA by switching genes on and off.

18 Jul 2017

Study identifies potential treatment for fetal alcohol spectrum disorder

Two commonly used drugs erased the learning and memory deficits caused by fetal alcohol exposure when the drugs were given after birth, thus potentially identifying a treatment for the disorder, reports a new Northwestern Medicine study.

18 Jul 2017

Scientists find simple way to raise accuracy of diagnostic tests and common assays

Scientists at the University of Washington have discovered a simple way to raise the accuracy of diagnostic tests for medicine and common assays for laboratory research.

18 Jul 2017

FDA approves first extended adjuvant therapy to lower risk of breast cancer recurrence

The U.S. Food and Drug Administration today approved Nerlynx (neratinib) for the extended adjuvant treatment of early-stage, HER2-positive breast cancer.

18 Jul 2017

NIH researchers show how investigational drug works against rare, fatal genetic disease

Scientists have demonstrated how an investigational drug works against a rare, fatal genetic disease, Niemann-Pick type C1 (NPC1).

17 Jul 2017

Immune system controls eye tissue regeneration in zebrafish, research finds

Researchers at Johns Hopkins Medicine report evidence that zebrafishes' natural ability to regenerate their eyes' retinal tissue can be accelerated by controlling the fishes' immune systems.

17 Jul 2017

Researchers discover new role of enzyme in promoting self-destruction of axons

Scientists in the Vollum Institute at OHSU have identified an enzyme that plays a crucial role in the degeneration of axons, the threadlike portions of a nerve cell that transmit signals within the nervous system.

14 Jul 2017

Researchers detect new gene mutation linked to Fanconi anemia

Fanconi anemia is a rare genetic disease characterized by bone marrow failure heralded by low platelet counts and unusually large red blood cells.

14 Jul 2017

Scientists reveal key role of excess gut calcium in C. diff infections

It lurks in hospitals and nursing homes, surviving the cleaning crew's attempt to kill it by holing up in a tiny hard shell. It preys upon patients already weak from disease or advanced age.

13 Jul 2017

Ground-breaking new breast cancer drugs have manageable toxicity profile for most patients

A ground-breaking new class of oral drugs for treating breast cancer, known as cyclin-dependent kinase (CDK) inhibitors, are generally well-tolerated, with a manageable toxicity profile for most patients.

13 Jul 2017

Erectile dysfunction drug may be used to coat stents in future heart surgeries

Coating stents with an erectile dysfunction drug may be the way forwards in treating stent patients, say researchers.

12 Jul 2017

Novel approach could offer hope in treatment of inflammatory conditions

The team, led by researchers at Imperial College London, Queen Mary University of London and Ergon Pharmaceuticals, believes the approach could offer new hope in the treatment of inflammatory conditions like arthritis, autoimmune diseases, and sepsis.

12 Jul 2017

Researchers synthesize nanoparticles with superior antioxidant properties to treat sepsis

With an incidence of 31.5 million worldwide and a mortality of around 17%, sepsis remains the most common cause of death in hospitalized patients, even in industrialized countries where antibiotics and critical care facilities are readily available.

12 Jul 2017

ERYTECH partners with Queen’s University to advance its product candidate for treating arginase-1 deficiency

ERYTECH Pharma, a French clinical-stage biopharmaceutical company developing innovative therapies for rare forms of cancer and orphan diseases, today announced that it has entered into a research collaboration with Queen's University in Canada to advance the preclinical development of ERYTECH's eryminase program specifically for the treatment of arginase-1 deficiency, a rare and severe metabolic disorder related to arginine metabolism.

12 Jul 2017

Enzyme News and Research

Low vitamin D may affect recovery of injured corneas

Novel model predicts single heart cell's response to dwindling supplies of oxygen

Study identifies new mutations linked to hereditary neuroendocrine tumors

Researchers find new way to protect stem cells from inflammation during wound repair

Genetic therapy for two inherited neurologic diseases moves closer to human clinical trials

Aggressive treatment for hypertension may lead to kidney damage, research suggests

Study provides insights into intergenerational inheritance of epigenetic information

Study identifies potential treatment for fetal alcohol spectrum disorder

Scientists find simple way to raise accuracy of diagnostic tests and common assays

FDA approves first extended adjuvant therapy to lower risk of breast cancer recurrence

NIH researchers show how investigational drug works against rare, fatal genetic disease

Immune system controls eye tissue regeneration in zebrafish, research finds

Researchers discover new role of enzyme in promoting self-destruction of axons

Researchers detect new gene mutation linked to Fanconi anemia

Scientists reveal key role of excess gut calcium in C. diff infections

Ground-breaking new breast cancer drugs have manageable toxicity profile for most patients

Erectile dysfunction drug may be used to coat stents in future heart surgeries

Novel approach could offer hope in treatment of inflammatory conditions

Researchers synthesize nanoparticles with superior antioxidant properties to treat sepsis

ERYTECH partners with Queen’s University to advance its product candidate for treating arginase-1 deficiency

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