Genes News and Research

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What genes affect the COVID-19 gender imbalance?

Many studies have established that coronavirus disease 2019 (COVID-19) is more infective in men than women, and men are more at risk of severe disease. While some have suggested that behavioral differences could explain increased transmission to men, this does not explain the more morbid prognosis.

16 Nov 2021

Novel long-read sequencing reveals complete repertoire of brain-expressed gene isoforms

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including the identification of novel isoforms of genes involved in diseases including Alzheimer's disease, autism and schizophrenia.

16 Nov 2021

Scientists identify new gene that contributes to type 1 diabetes progression

When the pro-inflammatory pair, a receptor called CCR2 and its ligand CCL-2, get together, it increases the risk of developing type 1 diabetes, scientists report.

16 Nov 2021

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Valsartan, an angiotensin II receptor blocker drug, delayed disease progression and improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy, according to results from a recent clinical trial published in Nature Medicine.

16 Nov 2021

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Scientists have hypothesized that the presence of regulatory sequences could be effectively used to instantaneously and accurately identify TRS sites as well as the related viral genes in unannotated coronavirus genomes.

16 Nov 2021

Researchers develop a highly efficient method to generate immune cells for cancer therapies

A Ludwig Cancer Research study has devised a highly efficient method to generate large numbers of immune cells specifically engineered to recognize neoantigens - small fragments of randomly mutated proteins that are typically unique to a patient's cancer - and destroy the tumors that express them.

15 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs (lncRNAs) – which are understudied in cancer research.

15 Nov 2021

Inflammatory chemicals involved in fat metabolism play key role in ALS, study shows

A new study using genetically engineered mice and human cell and tissue samples has added to evidence that higher levels of inflammatory chemicals involved in fat metabolism occur in people with amyotrophic lateral sclerosis (ALS), the neuromuscular disorder, also known as Lou Gehrig's disease.

15 Nov 2021

Lamin C important for keeping cell’s genetic material organized, research shows

In a study with lab-grown mouse cells, Johns Hopkins Medicine researchers say they have found that a protein that helps form a structural network under the surface of the cell's "command center" — its nucleus — is key to ensuring that DNA inside it remains orderly.

15 Nov 2021

Researchers discover new gene critical for daily behavioral rhythms

Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type. When a clock goes awry, sleep disruption or a variety of diseases can result.

15 Nov 2021

Could drugs derived from microalgae be effective against COVID-19?

Researchers discuss the ability of some microalgae metabolites to prevent cytokine storm syndrome during COVID-19.

15 Nov 2021

SARS-CoV-2 infection inhibited by CCR2 signaling

A new study discusses the role of monocytes in protecting individuals from SARS-CoV-2.

15 Nov 2021

Updated mapping of the human genetic architecture of COVID-19

In the present study, researchers presented extensive meta-analysis and added ten new genome-wide significant loci.

15 Nov 2021

Standard PCR tests do not pick up new Covid strains, warns expert

Some new strains of Covid-19 are not being picked up by standard PCR tests, reveals leading testing expert Dr Quinton Fivelman. He warns that new mutations mean some variants are not being picked up by the standard, widely-used, single gene tests.

15 Nov 2021

Scientists develop a single-cell chromatin atlas for the human genome

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome.

14 Nov 2021

Study improves understanding of the link between obesity and gum disease

Chronic inflammation caused by obesity may trigger the development of cells that break down bone tissue, including the bone that holds teeth in place, according to new University at Buffalo research that sought to improve understanding of the connection between obesity and gum disease.

12 Nov 2021

Rare disease diagnosis by 100,000 genomes pilot

A team of researchers conducted a pilot study that enrolled families and undertook detailed clinical phenotyping of the proband to evaluate the effect of the whole genome sequencing approach on a genetic diagnosis of rare conditions by the NHS in the UK.

12 Nov 2021

Regular blood tests can identify prostate cancer patients who are resistant to treatment

Regular blood tests before and during chemotherapy for prostate cancer can detect whether or not a patient is resistant or developing resistance to treatment with docetaxel, according to research presented at the NCRI Festival.

11 Nov 2021

Researchers identify gene expression involved in cancer progression and chemotherapy resistance

Even within a single patient with cancer, there is a vast diversity of individual tumor cells, which display distinct behaviors related to growth, metastasis, and responses to chemotherapy.

11 Nov 2021

Genes News and Research

What genes affect the COVID-19 gender imbalance?

Novel long-read sequencing reveals complete repertoire of brain-expressed gene isoforms

Scientists identify new gene that contributes to type 1 diabetes progression

Drug improved cardiac structure and function in patients with early-stage hypertrophic cardiomyopathy

Identification of transcription regulatory sequences and genes in previously unannotated coronaviruses

Researchers develop a highly efficient method to generate immune cells for cancer therapies

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

Inflammatory chemicals involved in fat metabolism play key role in ALS, study shows

Lamin C important for keeping cell’s genetic material organized, research shows

Researchers discover new gene critical for daily behavioral rhythms

Could drugs derived from microalgae be effective against COVID-19?

SARS-CoV-2 infection inhibited by CCR2 signaling

Updated mapping of the human genetic architecture of COVID-19

Standard PCR tests do not pick up new Covid strains, warns expert

Scientists develop a single-cell chromatin atlas for the human genome

Study improves understanding of the link between obesity and gum disease

Rare disease diagnosis by 100,000 genomes pilot

Regular blood tests can identify prostate cancer patients who are resistant to treatment

Researchers identify gene expression involved in cancer progression and chemotherapy resistance

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